ES2100806A1 - Procedimiento de obtencion de particulas de 1-ciclopropil-7-(4-etil-1-piperazinil)-6-fluoro-1,4-dihidro-4-oxo-3-acido quinolin carboxilico recubiertas. - Google Patents
Procedimiento de obtencion de particulas de 1-ciclopropil-7-(4-etil-1-piperazinil)-6-fluoro-1,4-dihidro-4-oxo-3-acido quinolin carboxilico recubiertas.Info
- Publication number
- ES2100806A1 ES2100806A1 ES09401647A ES9401647A ES2100806A1 ES 2100806 A1 ES2100806 A1 ES 2100806A1 ES 09401647 A ES09401647 A ES 09401647A ES 9401647 A ES9401647 A ES 9401647A ES 2100806 A1 ES2100806 A1 ES 2100806A1
- Authority
- ES
- Spain
- Prior art keywords
- quinolinecarboxylic acid
- coated particles
- piperazinyl
- cyclopropyl
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- SPFYMRJSYKOXGV-UHFFFAOYSA-N Baytril Chemical compound C1CN(CC)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 SPFYMRJSYKOXGV-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 230000004523 agglutinating effect Effects 0.000 abstract 1
- 210000005178 buccal mucosa Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000005354 coacervation Methods 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical class C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000007660 quinolones Chemical class 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE PARTICULAS DE 1-CICLOPROPIL-7-(4-ETIL-1-PIPERAZINIL)-6-FLUORO-1,4-DIHIDRO-4-OXO-3-ACIDO QUINOLIN CARBOXILICO RECUBIERTAS, SEGUN EL CUAL SE DISPERSA EL PRINCIPIO ACTIVO EN UN AGLUTINANTE POLIMERICO SOLUBLE EN AGUA, SEGUIDO DE ATOMIZACION, DE COACERVACION O DE GRANULACION. LAS PARTICULAS ASI OBTENIDAS PRESENTAN MENOR CONTACTO DIRECTO DEL PRINCIPIO ACTIVO CON LA MUCOSA BUCAL CONSIGUIENDOSE DE ESTA MANERA UNA FORMA DE ADMINISTRACION SIN LOS INCONVENIENTES QUE PRESENTA EL DESAGRADCABLE SABOR DEL PRINCIPIO ACTIVO QUE LLEGA A PROVOCAR EL RECHAZO, OBTENIENDOSE AL MISMO TIEMPO UNA BUENA TOLERANCIA GASTRICA Y UNA BUENA BIODISPONIBILIDAD. EL PRODUCTO ASI OBTENIDO ES DE UTILIDAD COMO ANTIBACTERIANO DE AMPLIO ESPECTRO. CON IDENTICOS METODOS PUEDEN OBTENERSE PARTICULAS RECUBIERTAS DEL RESTO DE ANTIBACTERIANOS DE AMPLIO ESPECTRO PERTENECIENTES A LA FAMILIA DE LAS QUINOLONAS O DERIVADOS DEL ACIDO QUINOLIN-CARBOXILICO.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9401647A ES2100806B1 (es) | 1994-07-27 | 1994-07-27 | Procedimiento de obtencion de particulas de 1-ciclopropil-7-(4-etil-1-piperazinil)-6-fluoro-1,4-dihidro-4-oxo-3-acido quinolin carboxilico recubiertas. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9401647A ES2100806B1 (es) | 1994-07-27 | 1994-07-27 | Procedimiento de obtencion de particulas de 1-ciclopropil-7-(4-etil-1-piperazinil)-6-fluoro-1,4-dihidro-4-oxo-3-acido quinolin carboxilico recubiertas. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2100806A1 true ES2100806A1 (es) | 1997-06-16 |
| ES2100806B1 ES2100806B1 (es) | 1998-02-16 |
Family
ID=8287056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9401647A Expired - Fee Related ES2100806B1 (es) | 1994-07-27 | 1994-07-27 | Procedimiento de obtencion de particulas de 1-ciclopropil-7-(4-etil-1-piperazinil)-6-fluoro-1,4-dihidro-4-oxo-3-acido quinolin carboxilico recubiertas. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2100806B1 (es) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0295495A1 (de) * | 1987-06-13 | 1988-12-21 | Bayer Ag | Ionenaustauscherharze beladen mit Chinoloncarbonsäurederivaten, ihre Herstellung und Verwendung |
| EP0443381A1 (en) * | 1990-02-14 | 1991-08-28 | Takeda Chemical Industries, Ltd. | Effervescent composition, its production and use |
| US5145853A (en) * | 1985-07-24 | 1992-09-08 | Bayer Aktiengesellschaft | Bactericidal formulations for use in veterinary medicine |
-
1994
- 1994-07-27 ES ES9401647A patent/ES2100806B1/es not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5145853A (en) * | 1985-07-24 | 1992-09-08 | Bayer Aktiengesellschaft | Bactericidal formulations for use in veterinary medicine |
| EP0295495A1 (de) * | 1987-06-13 | 1988-12-21 | Bayer Ag | Ionenaustauscherharze beladen mit Chinoloncarbonsäurederivaten, ihre Herstellung und Verwendung |
| EP0443381A1 (en) * | 1990-02-14 | 1991-08-28 | Takeda Chemical Industries, Ltd. | Effervescent composition, its production and use |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2100806B1 (es) | 1998-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19970616 Kind code of ref document: A1 Effective date: 19970616 |
|
| FD1A | Patent lapsed |
Effective date: 20040601 |