ES2101682T3 - Sintesis heterogenea de azepinonas a partir de esteres. - Google Patents

Sintesis heterogenea de azepinonas a partir de esteres.

Info

Publication number
ES2101682T3
ES2101682T3 ES90116565T ES90116565T ES2101682T3 ES 2101682 T3 ES2101682 T3 ES 2101682T3 ES 90116565 T ES90116565 T ES 90116565T ES 90116565 T ES90116565 T ES 90116565T ES 2101682 T3 ES2101682 T3 ES 2101682T3
Authority
ES
Spain
Prior art keywords
cyclized
methoxyphenyl
hydroxy
amino
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90116565T
Other languages
English (en)
Inventor
Daniel E Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ES2101682T3 publication Critical patent/ES2101682T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

UN COMPUESTO DE ESTER AMINO ACIDO PUEDE SER CONVERTIDO EN CICLICO COMO COMPUESTO CICLICO AMIDO CARBONILO POR CONTACTO DEL COMPUESTO ESTER AMINO ACIDO EN UN MEDIO LIQUIDO CON UNA SUSTANCIA HETEROGENEA ACIDA INTERCAMBIADORA DE IONES. POR EJEMPLO, ACIDO 2-HIDROXI-3-(2-AMINOFENILTIO)-3-(4-METOXIFENILO) PROPIONICO, ESTER METILO, TREOFORMO, PUEDE SER CONVERTIDO EN CICLICO EN UNA MEZCLA ACUOSA DENTRO CIS-2-(4-METOXIFENILO)-3-HIDROXI-2,3-DIHIDRO-1,5-BENZOTIACEPINA UNA RESINA INTERCAMBIADORA DE IONES DE POLIESTIRENO SULFATADO-DIVINILOBENCENO EN SU FORMA ACIDA, P.EJ., DOWEX 50X4-400, EN RENDIMIENTOS QUE EXCEDEN EL 85 DEL TEORICO, Y EL PRODUCTO PUEDE SER USADO PARA HACER HIDROCLORURO DE DILTIAZEM.
ES90116565T 1989-08-31 1990-08-29 Sintesis heterogenea de azepinonas a partir de esteres. Expired - Lifetime ES2101682T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40065889A 1989-08-31 1989-08-31

Publications (1)

Publication Number Publication Date
ES2101682T3 true ES2101682T3 (es) 1997-07-16

Family

ID=23584491

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90116565T Expired - Lifetime ES2101682T3 (es) 1989-08-31 1990-08-29 Sintesis heterogenea de azepinonas a partir de esteres.

Country Status (13)

Country Link
EP (1) EP0415384B1 (es)
JP (1) JP3090212B2 (es)
KR (1) KR0163585B1 (es)
AT (1) ATE150459T1 (es)
AU (1) AU628217B2 (es)
CA (1) CA2024124C (es)
DD (1) DD295367A5 (es)
DE (1) DE69030222T2 (es)
ES (1) ES2101682T3 (es)
HU (1) HU206103B (es)
IE (1) IE903151A1 (es)
IL (1) IL95509A (es)
ZA (1) ZA906810B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1249318B (it) * 1991-05-23 1995-02-22 Zambon Spa Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici
DE4313413A1 (de) * 1993-04-23 1994-10-27 Basf Ag 3-(Het)aryloxy(thio)-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
ZA893392B (en) * 1988-05-24 1990-01-31 Hoffmann La Roche Process for the manufacture of optically active naphthothiazepinones
ES2069003T3 (es) * 1989-04-28 1995-05-01 Tanabe Seiyaku Co Procedimiento para preparar derivados de 1,5-benzotiazepina.
JPH0798813B2 (ja) * 1989-04-28 1995-10-25 田辺製薬株式会社 １，５―ベンゾチアゼピン誘導体の製法

Also Published As

Publication number Publication date
DD295367A5 (de) 1991-10-31
JP3090212B2 (ja) 2000-09-18
KR0163585B1 (ko) 1998-12-01
HU905508D0 (en) 1991-02-28
HUT59118A (en) 1992-04-28
IE903151A1 (en) 1991-03-27
EP0415384B1 (en) 1997-03-19
DE69030222T2 (de) 1997-10-16
DE69030222D1 (de) 1997-04-24
KR910004584A (ko) 1991-03-29
EP0415384A3 (en) 1992-04-15
ATE150459T1 (de) 1997-04-15
IL95509A0 (en) 1991-06-30
AU6138290A (en) 1991-03-07
HU206103B (en) 1992-08-28
AU628217B2 (en) 1992-09-10
CA2024124A1 (en) 1991-03-01
CA2024124C (en) 2003-04-15
ZA906810B (en) 1991-10-30
EP0415384A2 (en) 1991-03-06
IL95509A (en) 1994-10-07
JPH0393778A (ja) 1991-04-18

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