ES2102021T3 - Nuevos antibioticos de aminosterol. - Google Patents

Nuevos antibioticos de aminosterol.

Info

Publication number
ES2102021T3
ES2102021T3 ES93905856T ES93905856T ES2102021T3 ES 2102021 T3 ES2102021 T3 ES 2102021T3 ES 93905856 T ES93905856 T ES 93905856T ES 93905856 T ES93905856 T ES 93905856T ES 2102021 T3 ES2102021 T3 ES 2102021T3
Authority
ES
Spain
Prior art keywords
aminosterol
antibiotics
new
colestano
aminopropil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93905856T
Other languages
English (en)
Inventor
Michael Zasloff
Karen Moore
Suzanne Wehrli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Hospital of Philadelphia CHOP
Original Assignee
Childrens Hospital of Philadelphia CHOP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hospital of Philadelphia CHOP filed Critical Childrens Hospital of Philadelphia CHOP
Application granted granted Critical
Publication of ES2102021T3 publication Critical patent/ES2102021T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

UN ANTIBIOTICO DEL AMINOSTEROL, (3(BETA)(N-[3-AMINOPROPIL]-1,4BUTANODIAMINO)-7ALFA,24 (-DIHIDROXI-5ALFA-COLESTANO 24-SULFATO), EL CUAL PUEDE AISLARSE DEL ESTOMAGO DEL TIBURON PERRO MARINO, SQUALUS ACANTHIAS.
ES93905856T 1992-03-18 1993-02-10 Nuevos antibioticos de aminosterol. Expired - Lifetime ES2102021T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/853,634 US5192756A (en) 1992-03-18 1992-03-18 Aminosterol antibiotic

Publications (1)

Publication Number Publication Date
ES2102021T3 true ES2102021T3 (es) 1997-07-16

Family

ID=25316541

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93905856T Expired - Lifetime ES2102021T3 (es) 1992-03-18 1993-02-10 Nuevos antibioticos de aminosterol.

Country Status (11)

Country Link
US (1) US5192756A (es)
EP (1) EP0637243B1 (es)
JP (1) JP3286321B2 (es)
AT (1) ATE152120T1 (es)
AU (1) AU675782B2 (es)
CA (1) CA2130803C (es)
DE (1) DE69310169T2 (es)
DK (1) DK0637243T3 (es)
ES (1) ES2102021T3 (es)
GR (1) GR3023749T3 (es)
WO (1) WO1993018773A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693769A (en) * 1991-12-13 1997-12-02 Transcell Technologies, Inc. Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
US5795870A (en) * 1991-12-13 1998-08-18 Trustees Of Princeton University Compositions and methods for cell transformation
US5780444A (en) * 1991-12-13 1998-07-14 Trustees Of Princeton University Compositions and methods for cell transformation
AU6392894A (en) * 1993-02-26 1994-09-14 Magainin Pharmaceuticals, Inc. Chemical synthesis of squalamine
WO1994020520A1 (en) * 1993-03-10 1994-09-15 Magainin Pharmaceuticals Inc. Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants
ES2164110T3 (es) * 1994-03-10 2002-02-16 Magainin Pharma Usos farmaceuticos de derivados de esteroides.
US5856535A (en) * 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
US5840740A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds and a method of treating infection using the aminosterol compounds
US6143738A (en) * 1995-06-07 2000-11-07 Magainin Pharmaceuticals, Inc. Therapeutic uses for an aminosterol compound
US5792635A (en) * 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5874597A (en) * 1995-06-07 1999-02-23 Magainin Pharmaceuticals, Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
AU723663C (en) * 1995-06-07 2001-11-01 Magainin Pharmaceuticals, Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE), pharmaceutical methods and compositions employing such inhibitors, and processes for evaluating the NHE-inhibitory efficacy of compounds
US5994336A (en) * 1995-06-07 1999-11-30 Magainin Pharmaceuticals Inc. Method of inhibiting proliferation of cells by administering an aminosterol compound
US5840936A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US5795885A (en) * 1995-06-07 1998-08-18 Magainin Pharmaceuticals Inc. Method of inhibiting profileration of cells by administering an aminosterol compound
US5763430A (en) * 1995-06-07 1998-06-09 Magainin Pharmaceuticals Inc. Method of treating a viral infection by administering a steroid compound
WO1997026888A1 (en) * 1996-01-26 1997-07-31 Alcon Laboratories, Inc. Use of squalamine and its analogues in ophthalmic compositions
US6596712B2 (en) 1996-04-26 2003-07-22 Genaera Corporation Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
PT910382E (pt) * 1996-04-26 2003-10-31 Genaera Corp Esqualamina em combinacao com outros agentes anti-cancro para o tratamento de tumores
US7410959B1 (en) 2000-07-13 2008-08-12 Genaera Corporation Therapeutic uses for aminosterol compounds
US6262283B1 (en) 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
WO2000009137A2 (en) * 1998-08-12 2000-02-24 Magainin Pharmaceuticals, Inc. Aminosterol compounds and uses thereof
DK1274718T3 (da) * 2000-04-12 2007-02-12 Genaera Corp En fremgangsmåde til forberedelse af 7.alpha.-hydroxy 3-aminosubstituerede steroler vee en ubeskyttet 7.alpha.-hydroxy gruppe
US7309501B2 (en) * 2001-06-21 2007-12-18 Mote Marine Laboratory Conditioned media to inhibit growth of tumor cells
US6908627B2 (en) * 2001-06-21 2005-06-21 Mote Marine Laboratory Conditioned media for inhibiting growth of tumor cells
ES2732251T3 (es) 2005-04-25 2019-11-21 Enterin Inc Dilactato de escualamina cristalino
WO2009032321A2 (en) * 2007-09-06 2009-03-12 Genaera Corporation A method for treating diabetes
US8729058B2 (en) * 2009-10-27 2014-05-20 Michael Zasloff Methods and compositions for treating and preventing viral infections
WO2011066260A2 (en) * 2009-11-25 2011-06-03 Michael Zasloff Formulations comprising aminosterols
FR2981351A1 (fr) 2011-10-17 2013-04-19 Univ Nice Sophia Antipolis Derives aminosteroidiens anti-diabetiques
US10040817B2 (en) 2013-10-03 2018-08-07 Enterin Laboratories, Inc. Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same
US9738684B2 (en) 2015-06-29 2017-08-22 Council Of Scientific & Industrial Research N-terminally modified linear and branched polyamine conjugated peptidomimetics as antimicrobials agents
US11083735B2 (en) 2017-09-08 2021-08-10 Enterin, Inc. Methods for treating sleep disorders, sleep disturbances, and related symptoms using aminosterol compositions
US11066438B2 (en) 2017-10-30 2021-07-20 Enterin, Inc. Squalamine solid forms and methods of making the same
US20210260078A1 (en) * 2018-08-03 2021-08-26 Philadelphia Low dosage intranasal aminosterol dosage forms and methods of using the same
US11464789B2 (en) 2018-08-03 2022-10-11 Enterin, Inc. Aminosterol compositions and methods of using the same for treating schizophrenia
US20230125585A1 (en) 2019-08-02 2023-04-27 Enterin, Inc. Dosing protocols and regimens for aminosterol treatment
US12503485B2 (en) 2019-08-02 2025-12-23 Enterin, Inc. Human aminosterol ENT-03 compounds, related compositions comprising the same, and methods of using the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3308116A (en) * 1963-07-05 1967-03-07 Ormonoterapia Richter Spa 2-carboxy amide-3-amino and 2, 3-isoxazole steroids
US3629298A (en) * 1969-02-24 1971-12-21 Upjohn Co Steroidal 3-keto-delta 1 4-diene-3-enamines
US3931403A (en) * 1973-05-25 1976-01-06 Intellectual Property Development Corporation Antimicrobial compositions

Also Published As

Publication number Publication date
CA2130803C (en) 2007-04-17
JPH07504910A (ja) 1995-06-01
US5192756A (en) 1993-03-09
EP0637243B1 (en) 1997-04-23
ATE152120T1 (de) 1997-05-15
CA2130803A1 (en) 1993-09-30
JP3286321B2 (ja) 2002-05-27
AU675782B2 (en) 1997-02-20
GR3023749T3 (en) 1997-09-30
DE69310169T2 (de) 1997-09-18
DK0637243T3 (da) 1997-05-20
DE69310169D1 (de) 1997-05-28
WO1993018773A1 (en) 1993-09-30
AU3661993A (en) 1993-10-21
EP0637243A4 (en) 1995-12-13
EP0637243A1 (en) 1995-02-08

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