ES2102529T3 - Oligo-2'-desoxi-nucleotidos y su utilizacion como medicamentos con actividad antivirica. - Google Patents

Oligo-2'-desoxi-nucleotidos y su utilizacion como medicamentos con actividad antivirica.

Info

Publication number
ES2102529T3
ES2102529T3 ES92924466T ES92924466T ES2102529T3 ES 2102529 T3 ES2102529 T3 ES 2102529T3 ES 92924466 T ES92924466 T ES 92924466T ES 92924466 T ES92924466 T ES 92924466T ES 2102529 T3 ES2102529 T3 ES 2102529T3
Authority
ES
Spain
Prior art keywords
nucleotidos
antivirically
desoxi
oligo
medicines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92924466T
Other languages
English (en)
Inventor
Klaus Muhlegger
Der Eltz Herbert Von
Frank Seela
Helmut Rosemeyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2102529T3 publication Critical patent/ES2102529T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

NUCLEOTIDOS OLIGODESOXYRIBO, EN LOS CUALES CADA VEZ EN LOS EXTREMOS 5'' Y 3'' ESTAN SUSTITUIDOS POR LO MENOS 2 GRUPOS 2''-DESOXY .PENTOFURANOSILO, Y NUCLEOTIDOS OLIGODESOXYRIBO, EN LOS CUALES POR LO MENOS EL 20% DE LOS GRUPOS 2''-DESOXYRANOXILO ESTAN SUSTITUIDOS EN LAS UNIDADES NUCLEOTIDAS SUCESIVAS POR GRUPOS 2''-DESOXY SE COMPONEN DE 6 OLIGODESOXIRIBO SON APROPIADOS PARA USO COMO INHIBIDORES ANTISENTIDO DE LA EXPRESION DE GENES Y ONCOGENES VIRALES Y SE PUEDEN USAR EN LA PREPARACION DE FARMACOS CON ACCION ANTIVIRAL.
ES92924466T 1991-05-25 1992-05-25 Oligo-2'-desoxi-nucleotidos y su utilizacion como medicamentos con actividad antivirica. Expired - Lifetime ES2102529T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4117186A DE4117186A1 (de) 1991-05-25 1991-05-25 Oligo-2'-desoxynukleotide und ihre verwendung als arzneimittel mit antiviraler wirksamkeit

Publications (1)

Publication Number Publication Date
ES2102529T3 true ES2102529T3 (es) 1997-08-01

Family

ID=6432469

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92924466T Expired - Lifetime ES2102529T3 (es) 1991-05-25 1992-05-25 Oligo-2'-desoxi-nucleotidos y su utilizacion como medicamentos con actividad antivirica.

Country Status (8)

Country Link
EP (1) EP0611373B1 (es)
JP (1) JP2683296B2 (es)
AT (1) ATE150763T1 (es)
CA (1) CA2103062C (es)
DE (2) DE4117186A1 (es)
DK (1) DK0611373T3 (es)
ES (1) ES2102529T3 (es)
WO (1) WO1992021692A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7572582B2 (en) 1997-09-12 2009-08-11 Exiqon A/S Oligonucleotide analogues

Also Published As

Publication number Publication date
CA2103062A1 (en) 1992-11-26
ATE150763T1 (de) 1997-04-15
EP0611373B1 (de) 1997-03-26
CA2103062C (en) 2004-11-30
DK0611373T3 (da) 1997-10-06
JPH06502655A (ja) 1994-03-24
DE4117186A1 (de) 1992-11-26
EP0611373A1 (de) 1994-08-24
JP2683296B2 (ja) 1997-11-26
WO1992021692A1 (de) 1992-12-10
DE59208280D1 (de) 1997-04-30

Similar Documents

Publication Publication Date Title
ES2150567T3 (es) Antagonistas del factor de liberacion de la corticotropina.
GT199800046A (es) Compuestos de pirazina.
GT199900150A (es) 1,2,3,4-tetrahidroquinolinas 2-sustituidas 4-carboxiamino sustituidas.
ES2051772T3 (es) 2-sustituido-e-fusionado-(1,2,4)-triazol(1,5-c)pirimidinas, composiciones farmaceuticas y sus usos.
MX9301634A (es) Quinuclidinas peptidicas.
ES2127946T3 (es) Antagonistas de neurocinina diazabiciclica.
ATE154029T1 (de) 7-deazapurin modifizierte oligonukleotide
ES2132105T3 (es) 2-aminometil-cromanos como principios activos en farmacos para el tratamiento de enfermedades del sistema nervioso central.
ES2059558T3 (es) Ciclosporins y su uso como productos farmaceuticos.
ES2138969T3 (es) Combinacion de nucleosidos antivirales.
MX9203018A (es) Fluoroalcoxibencilamino-derivados de heterociclos nitrogenados.
ES2040838T3 (es) Compuestos piperazinil-heterociclicos.
ES2131116T3 (es) Analogos de nucleotidos enantiomericos antirretrovirales.
ES2132223T3 (es) Derivados de indol condensados en calidad de antagonistas del receptor 5-ht4.
PA8491001A1 (es) Inhibidores de la recaptacion de monoaminas para el tratamiento de trastornos del snc.
SV2002000289A (es) Antagonistas del factor liberador de la corticotropina ref. pc10759/20117/bb
ES2061684T3 (es) Compuestos de benzoxazina y su uso farmaceutico.
ES2179945T3 (es) Compuestos de tetralina con actividad de resistencia a multiples farmacos.
GT199900185A (es) Novedosa pirimidin-4-enamina como fungicida.
ES2089687T3 (es) 4-fenil-piridonas y 4-fenil-2-alcoxipiridinas sustituidas como inhibidores de la hmg-coa-reductasa.
ES2115904T3 (es) Derivados amino ramificados del tiazol, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen.
ES2145129T3 (es) Derivados de benzopirano y benzoxazina.
ES2167021T3 (es) Derivados de acido 4-bifenil-4-hidroxibutirico sustituidos como inhibidores de metaloproteasa de matriz.
AR248011A1 (es) Procedimiento para la fabricacion de un derivado de diamidin-difenil-alquileno.
FI932997A0 (fi) Antivirala foereningar

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 611373

Country of ref document: ES