ES2103014T3 - Derivados de aminooxipirrolidiniltiocarbapenema. - Google Patents
Derivados de aminooxipirrolidiniltiocarbapenema.Info
- Publication number
- ES2103014T3 ES2103014T3 ES92111356T ES92111356T ES2103014T3 ES 2103014 T3 ES2103014 T3 ES 2103014T3 ES 92111356 T ES92111356 T ES 92111356T ES 92111356 T ES92111356 T ES 92111356T ES 2103014 T3 ES2103014 T3 ES 2103014T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- protective group
- aminooxypyrrolidinylthiocarbapenem
- thiol
- imino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000006239 protecting group Chemical group 0.000 abstract 3
- KIIBHRNKYOKDNM-PEHGTWAWSA-N (5S)-4-aminooxy-4-pyrrolidin-1-ylsulfanyl-1-azabicyclo[3.2.0]hept-2-en-7-one Chemical compound NOC1(C=CN2[C@H]1CC2=O)SN1CCCC1 KIIBHRNKYOKDNM-PEHGTWAWSA-N 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Abstract
SE PRESENTAN UN AMINOOXIPIRROLIDINILTIOCARBAPENEM ANTIBACTERIANO (I), SU PRODUCCION A PARTIR DEL CARBAPENEM V Y DEL TIOL VI CORRESPONDIENTES, SU FORMULACION FARMACEUTICA Y SU EMPLEO PARA COMBATIR BACTERIAS. EL AMINOOXIPIRROLIDINILTIOCARBAPENEM (I) Y SUS COMPUESTOS INTERMEDIOS (V) Y (VI) TIENEN LAS SIGUIENTES FORMULAS: (EN DONDE R ES OPCIONALMENTE AMINO SUBSTITUIDO; R1 ES HIDROGENO O 1C A 5C ALQUILO; R2 ES HIDROGENO O UN GRUPO PROTECTOR HIDROXI CONVENCIONAL; R3 ES HIDROGENO O UN GRUPO PROTECTOR IMINO O SUBSTITUYENTE DEL IMINO; R4 ES 1C A 5C ALQUILENO; Y R5 ES HIDROGENO O UN GRUPO PROTECTOR CARBOXI CONVENCIONAL; X ES UN GRUPO SALIENTE; R6 ES HIDROGENO O UN GRUPO PROTECTOR TIOL; Y CADA UNA DE LAS LINEAS ONDULADAS MUESTRA UN ENLACE EN CONFIGURACION DE R O S Y SUS SALES).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16424791 | 1991-07-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2103014T3 true ES2103014T3 (es) | 1997-08-16 |
Family
ID=15789474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92111356T Expired - Lifetime ES2103014T3 (es) | 1991-07-04 | 1992-07-03 | Derivados de aminooxipirrolidiniltiocarbapenema. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5360798A (es) |
| EP (1) | EP0521524B1 (es) |
| JP (1) | JP3296845B2 (es) |
| KR (1) | KR100215514B1 (es) |
| AT (1) | ATE151424T1 (es) |
| DE (1) | DE69218843T2 (es) |
| DK (1) | DK0521524T3 (es) |
| ES (1) | ES2103014T3 (es) |
| GR (1) | GR3023607T3 (es) |
| TW (1) | TW208008B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9515975D0 (en) | 1995-08-04 | 1995-10-04 | Zeneca Ltd | Chemical compounds |
| JP2001500118A (ja) | 1996-08-17 | 2001-01-09 | ゼネカ・リミテッド | ファルネシルタンパク質トランスフェラーゼ阻害剤としての３―メルカプトピロリジン |
| AU740327C (en) * | 1997-02-07 | 2002-05-09 | Kyoto Pharmaceutical Industries, Ltd. | Carbapenem compounds, use thereof and intermediate compound therefor |
| YU66700A (sh) | 1998-05-01 | 2003-01-31 | Kyoto Pharmaceutical Industries Ltd. | Derivati karbapenema, njihovo korišćenje i intermedijarna jedinjenja istih |
| GB9930317D0 (en) | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
| GB9930318D0 (en) | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
| KR100551853B1 (ko) * | 2000-07-19 | 2006-02-13 | 에프. 호프만-라 로슈 아게 | 피리미딘 유도체 |
| PL366943A1 (en) * | 2001-05-21 | 2005-02-07 | Kyoto Pharmaceutical Industries, Ltd. | Carbapenem compound |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4251541A (en) * | 1979-01-09 | 1981-02-17 | A. H. Robins Company, Inc. | 1-Substituted-3-arylthio-4-hydroxypyrrolidines |
| CA1281720C (en) * | 1984-11-08 | 1991-03-19 | Makoto Sunagawa | Carbapenem compounds and production thereof |
| EP0243686B1 (en) * | 1986-03-27 | 1992-07-15 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production |
| KR880006244A (ko) * | 1986-11-24 | 1988-07-22 | 후지사와 도모 기찌 로 | 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법 |
| GB8811237D0 (en) * | 1988-05-12 | 1988-06-15 | Fujisawa Pharmaceutical Co | 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives |
-
1992
- 1992-06-10 US US07/896,669 patent/US5360798A/en not_active Expired - Lifetime
- 1992-06-29 TW TW081105108A patent/TW208008B/zh active
- 1992-07-03 AT AT92111356T patent/ATE151424T1/de not_active IP Right Cessation
- 1992-07-03 JP JP17664592A patent/JP3296845B2/ja not_active Expired - Fee Related
- 1992-07-03 ES ES92111356T patent/ES2103014T3/es not_active Expired - Lifetime
- 1992-07-03 DK DK92111356.9T patent/DK0521524T3/da active
- 1992-07-03 EP EP92111356A patent/EP0521524B1/en not_active Expired - Lifetime
- 1992-07-03 DE DE69218843T patent/DE69218843T2/de not_active Expired - Fee Related
- 1992-07-04 KR KR1019920011935A patent/KR100215514B1/ko not_active Expired - Fee Related
-
1994
- 1994-07-12 US US08/273,979 patent/US5523415A/en not_active Expired - Fee Related
-
1997
- 1997-05-30 GR GR970401251T patent/GR3023607T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP3296845B2 (ja) | 2002-07-02 |
| US5523415A (en) | 1996-06-04 |
| GR3023607T3 (en) | 1997-08-29 |
| DE69218843D1 (de) | 1997-05-15 |
| EP0521524A1 (en) | 1993-01-07 |
| KR930002350A (ko) | 1993-02-23 |
| TW208008B (es) | 1993-06-21 |
| EP0521524B1 (en) | 1997-04-09 |
| KR100215514B1 (ko) | 1999-08-16 |
| DE69218843T2 (de) | 1997-10-09 |
| DK0521524T3 (da) | 1997-05-05 |
| US5360798A (en) | 1994-11-01 |
| ATE151424T1 (de) | 1997-04-15 |
| JPH05186467A (ja) | 1993-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU6601294A (en) | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | |
| DK0598129T3 (da) | Nye tetrapeptidderivater | |
| AU692090B2 (en) | Novel 4,6-diarylpyrimidine derivatives and salts thereof | |
| EP0705833A4 (en) | DC-89 DERIVATIVES | |
| AU1200695A (en) | 4,5-diaryloxazole derivatives | |
| HU9600834D0 (en) | Quinazoline derivatives | |
| MD1560F2 (en) | Cyclic compounds, pharmaceutical compositions on base thereof and methods of treatment of infections or diseases provoked by retroviruses. | |
| ES2103014T3 (es) | Derivados de aminooxipirrolidiniltiocarbapenema. | |
| ES2117264T3 (es) | Nuevo compuesto con actividad inhibitoria de la agregacion plaquetaria. | |
| EP0546177A4 (en) | BENZOPYRANE DERIVATIVE, PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME. | |
| ATE190308T1 (de) | Epoxycyclohexendionderivat | |
| DE69600231D1 (de) | N-Arylalkylphenylacetamidderivate | |
| AU4732096A (en) | Remedy for pulmonary heart | |
| DK0566288T3 (da) | Flavon-derivater | |
| AU2353595A (en) | Antitumor indolopyprolocarbazole derivative | |
| BR9508521A (pt) | Inibição da biossintese de leucotrienos com derivados de uréia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 521524 Country of ref document: ES |