ES2103254T3 - Procedimiento para la preparacion de acido halosustituido aromatico. - Google Patents

Procedimiento para la preparacion de acido halosustituido aromatico.

Info

Publication number
ES2103254T3
ES2103254T3 ES96919779T ES96919779T ES2103254T3 ES 2103254 T3 ES2103254 T3 ES 2103254T3 ES 96919779 T ES96919779 T ES 96919779T ES 96919779 T ES96919779 T ES 96919779T ES 2103254 T3 ES2103254 T3 ES 2103254T3
Authority
ES
Spain
Prior art keywords
acid
procedure
preparation
solution
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96919779T
Other languages
English (en)
Other versions
ES2103254T1 (es
Inventor
Marina Mauro
Carlo Felice Viscardi
Massimo Gagna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco SpA
Original Assignee
Bracco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI951045A external-priority patent/IT1274547B/it
Priority claimed from ITRM950549 external-priority patent/IT1277899B1/it
Application filed by Bracco SpA filed Critical Bracco SpA
Publication of ES2103254T1 publication Critical patent/ES2103254T1/es
Application granted granted Critical
Publication of ES2103254T3 publication Critical patent/ES2103254T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO PAR ALA PREPARACION DE ACIDO 5-AMINO-2,4,6-TRIYODO-1,3BENCENODICARBOXILICO, QUE COMPRENDE LOS SIGUIENTES PASOS: A) HIDROGENACION CATALITICA DE ACIDO 5-NITRO-1,3BENCENODICARBOXILICO EN UN MEDIO NEUTRO O BASICO, LO CUAL PROPORCIONA UNA SOLUCION ACUOSA DE SAL DE SODIO DE ACIDO 5-AMINO1,3-BENCENODICARBOXILICO; B) TRATAMIENTO CON YODO DIRECTO DE LA SOLUCION DE SAL DE SODIO DE ACIDO 5-AMINO-1,3BENCENODICARBOXILICO QUE DERIVA DEL PASO A), SIN PURIFICACION POSTERIOR, CON UNA SOLUCION DE ICI EN HCI, SIENDO LA SOLUCION DE SAL DE SODIO DE ACIDO 5-AMINO-BENCENODICARBOXILICO PREVIAMENTE AÑADIDA CON HCI Y H{SUB,2}SO{SUB,4}.
ES96919779T 1995-05-23 1996-05-17 Procedimiento para la preparacion de acido halosustituido aromatico. Expired - Lifetime ES2103254T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI951045A IT1274547B (it) 1995-05-23 1995-05-23 Processo per la preparazione dell'acido 5-ammino-2,4,6- triiodoisoftalico
ITRM950549 IT1277899B1 (it) 1995-08-04 1995-08-04 Processo per la preparazione dell'acido 5-ammino-2,4,6 -triiodo- isoftalico"

Publications (2)

Publication Number Publication Date
ES2103254T1 ES2103254T1 (es) 1997-09-16
ES2103254T3 true ES2103254T3 (es) 2000-07-01

Family

ID=26331278

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96919779T Expired - Lifetime ES2103254T3 (es) 1995-05-23 1996-05-17 Procedimiento para la preparacion de acido halosustituido aromatico.

Country Status (23)

Country Link
US (1) US5763650A (es)
EP (1) EP0773923B1 (es)
JP (1) JP4012568B2 (es)
KR (1) KR100269079B1 (es)
CN (1) CN1109670C (es)
AT (1) ATE192138T1 (es)
AU (1) AU707177B2 (es)
BR (1) BR9606487A (es)
CA (1) CA2195635C (es)
CZ (1) CZ289771B6 (es)
DE (2) DE69607921T2 (es)
DK (1) DK0773923T3 (es)
ES (1) ES2103254T3 (es)
GR (2) GR970300029T1 (es)
HU (1) HU217686B (es)
IL (1) IL118360A (es)
MX (1) MX9700549A (es)
NO (1) NO314257B1 (es)
PL (1) PL318285A1 (es)
PT (1) PT773923E (es)
SI (1) SI9620011A (es)
SK (1) SK8997A3 (es)
WO (1) WO1996037458A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007073202A1 (en) 2005-12-19 2007-06-28 Ge Healthcare As Purification process of iodixanol
ES2391002T3 (es) * 2008-01-14 2012-11-20 Mallinckrodt Llc Proceso para la preparación de iosimenol
EP2093206A1 (en) * 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Process for the iodination of aromatic compounds
EP2230227A1 (en) 2009-03-20 2010-09-22 Bracco Imaging S.p.A Process for the preparation of triiodinated carboxylic aromatic derivatives
EP2243767A1 (en) * 2009-04-21 2010-10-27 Bracco Imaging S.p.A Process for the iodination of aromatic compounds
JP5661762B2 (ja) * 2009-07-07 2015-01-28 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． ヨウ素化剤の製造方法
US7999135B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using ultrasound
US7999134B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using milling
KR101699226B1 (ko) 2009-11-26 2017-01-24 호비온 차이나 홀딩 리미티드 이오딕사놀의 제조 및 정제
EP2394984A1 (en) 2010-06-10 2011-12-14 Bracco Imaging S.p.A Process for the iodination of phenolic derivatives
CA2897700C (en) 2012-12-11 2022-05-03 Bracco Imaging S.P.A. Continuous process for the preparation of (s)-2-acetyloxypropionic acid chloride
PL3066071T3 (pl) 2013-11-05 2018-09-28 Bracco Imaging S.P.A Sposób otrzymywania jopamidolu
DK3154928T3 (da) 2014-06-10 2020-05-18 Bracco Imaging Spa Fremgangsmåde til fremstilling af (s)-2-acetyloxypropionsyre og derivater deraf
KR102562581B1 (ko) 2017-06-07 2023-08-02 브라코 이미징 에스.피.에이. 수성 용액으로부터 요오드의 회수 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2820814A (en) * 1955-03-21 1958-01-21 Schering Corp Polyiodinated 5-aminoisophthalic acids, salts, and esters
SU502875A1 (ru) * 1973-03-26 1976-02-15 Войсковая Часть 41598 Способ получени метилового эфира 4-диметиламиносалициловой кислоты
SU502874A1 (ru) * 1973-12-07 1976-02-15 Институт Органического Катализа И Электрохимии Способ получени м-аминоизофталевой кислоты
US4102917A (en) * 1977-06-01 1978-07-25 American Cyanamid Company Substituted phenyl naphthalenesulfonic acids
JP2765696B2 (ja) * 1989-12-27 1998-06-18 三井化学株式会社 ５―アミノ―２，４，６―トリヨードイソフタル酸の製造方法

Also Published As

Publication number Publication date
EP0773923B1 (en) 2000-04-26
ES2103254T1 (es) 1997-09-16
CZ18597A3 (en) 1997-07-16
NO970263L (no) 1997-03-24
IL118360A0 (en) 1996-09-12
WO1996037458A1 (en) 1996-11-28
GR3033957T3 (en) 2000-11-30
NO970263D0 (no) 1997-01-21
DE69607921D1 (de) 2000-05-31
AU707177B2 (en) 1999-07-01
CA2195635C (en) 2008-07-22
CA2195635A1 (en) 1996-11-28
SK8997A3 (en) 1997-08-06
US5763650A (en) 1998-06-09
BR9606487A (pt) 1997-11-25
JPH10503530A (ja) 1998-03-31
EP0773923A1 (en) 1997-05-21
HUP9700189A1 (hu) 1998-01-28
HU217686B (hu) 2000-03-28
JP4012568B2 (ja) 2007-11-21
MX9700549A (es) 1997-05-31
PL318285A1 (en) 1997-06-09
DE69607921T2 (de) 2000-08-17
KR100269079B1 (ko) 2000-10-16
AU5818996A (en) 1996-12-11
ATE192138T1 (de) 2000-05-15
DE773923T1 (de) 1997-12-18
NO314257B1 (no) 2003-02-24
IL118360A (en) 1999-12-22
SI9620011A (en) 1997-06-30
CN1154688A (zh) 1997-07-16
HUP9700189A3 (en) 1998-03-02
CZ289771B6 (cs) 2002-04-17
GR970300029T1 (en) 1997-09-30
DK0773923T3 (da) 2000-09-04
PT773923E (pt) 2000-08-31
CN1109670C (zh) 2003-05-28

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