ES2103482T3 - Antigeno de linfocitos t citotoxicos utilizado como inhibidor de la cisteina proteasa. - Google Patents

Antigeno de linfocitos t citotoxicos utilizado como inhibidor de la cisteina proteasa.

Info

Publication number
ES2103482T3
ES2103482T3 ES93917127T ES93917127T ES2103482T3 ES 2103482 T3 ES2103482 T3 ES 2103482T3 ES 93917127 T ES93917127 T ES 93917127T ES 93917127 T ES93917127 T ES 93917127T ES 2103482 T3 ES2103482 T3 ES 2103482T3
Authority
ES
Spain
Prior art keywords
cytotoxic
pct
lymphocyte antigen
inhibitor
cysteine protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93917127T
Other languages
English (en)
Inventor
Daniel Muller
Katherine Delaria
Linda Wallace
Elise Brownell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of ES2103482T3 publication Critical patent/ES2103482T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE DESCRIBEN MOLECULAS QUE INHIBEN LA ACTIVIDAD PROTEOLITICA DE PROTEASAS DE CISTEINA TALES COMO CATEPSINA H, CATEPSINA L Y PAPAINA, Y METODOS PARA USAR MOLECULAS QUE TIENEN LAS PROPIEDADES BIOLOGICAS DE ANTIGENO CITOTOXICO DE LINFOCITO T PARA INHIBIR PROTEASAS DE CISTEINA E INHIBIR LA DEGRADACION DE PROTEOGLUCANO.
ES93917127T 1992-07-17 1993-07-15 Antigeno de linfocitos t citotoxicos utilizado como inhibidor de la cisteina proteasa. Expired - Lifetime ES2103482T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91592392A 1992-07-17 1992-07-17

Publications (1)

Publication Number Publication Date
ES2103482T3 true ES2103482T3 (es) 1997-09-16

Family

ID=25436438

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93917127T Expired - Lifetime ES2103482T3 (es) 1992-07-17 1993-07-15 Antigeno de linfocitos t citotoxicos utilizado como inhibidor de la cisteina proteasa.

Country Status (9)

Country Link
US (2) US5973110A (es)
EP (1) EP0651764B1 (es)
AT (1) ATE152731T1 (es)
CA (1) CA2140127C (es)
DE (1) DE69310517T2 (es)
DK (1) DK0651764T3 (es)
ES (1) ES2103482T3 (es)
GR (1) GR3024267T3 (es)
WO (1) WO1994002504A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629469A (en) * 1994-03-10 1997-05-13 Sandoz Ltd. Thiol protease inhibitor
WO1997000969A1 (de) * 1995-06-20 1997-01-09 Johannes Schumacher Verfahren und vorrichtung zur bestimmung der aktivität von enzymen in flüssigkeiten, beziehungsweise der konzentration und/oder aktivität von inhibitoren in flüssigkeiten
WO2004097723A1 (en) 2003-04-29 2004-11-11 Anoto Ip Lic Hb Methods, apparatus, computer program and storage medium for position decoding
US8759019B2 (en) * 2007-07-06 2014-06-24 Papst Licensing Gmbh & Co. Kg Method for measuring the activity of proteases
DE102009004371A1 (de) 2009-01-08 2010-07-15 Papst Licensing Gmbh & Co. Kg Vorrichtung und Verfahren zum Messen der Aktivität von Enzymen nach Inhibitorentzug

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710014A (en) * 1988-02-11 1998-01-20 The United States Of America As Represented By The Department Of Health And Human Services Cloned cDNA for human procathepsin l.
US5189144A (en) * 1989-04-28 1993-02-23 Takara Shuzo Co., Ltd. Human calpastatin-like polypeptide

Also Published As

Publication number Publication date
CA2140127C (en) 1998-09-29
US5973110A (en) 1999-10-26
GR3024267T3 (en) 1997-10-31
CA2140127A1 (en) 1994-02-03
DE69310517T2 (de) 1997-10-02
DE69310517D1 (en) 1997-06-12
US5962633A (en) 1999-10-05
EP0651764A1 (en) 1995-05-10
ATE152731T1 (de) 1997-05-15
WO1994002504A1 (en) 1994-02-03
DK0651764T3 (da) 1997-12-08
EP0651764B1 (en) 1997-05-07

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