ES2103680A1 - Procedimiento de preparacion de n-metil-3-fenil-3- (p-trifluorometil-fenoxi)propilamina. - Google Patents

Procedimiento de preparacion de n-metil-3-fenil-3- (p-trifluorometil-fenoxi)propilamina.

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Publication number
ES2103680A1
ES2103680A1 ES09501582A ES9501582A ES2103680A1 ES 2103680 A1 ES2103680 A1 ES 2103680A1 ES 09501582 A ES09501582 A ES 09501582A ES 9501582 A ES9501582 A ES 9501582A ES 2103680 A1 ES2103680 A1 ES 2103680A1
Authority
ES
Spain
Prior art keywords
trifluoromethylphenoxy
phenyl
converting
reaction
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09501582A
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English (en)
Other versions
ES2103680B1 (es
Inventor
Carmen Dominguez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly SA
Original Assignee
Lilly SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly SA filed Critical Lilly SA
Priority to ES9501582A priority Critical patent/ES2103680B1/es
Publication of ES2103680A1 publication Critical patent/ES2103680A1/es
Application granted granted Critical
Publication of ES2103680B1 publication Critical patent/ES2103680B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE N-METIL-3-FENIL-3-(P-TRIFLUOROMETILFENOXI)PROPILAMINA. CONSTA DE LAS SIGUIENTES ETAPAS: HACER REACCIONAR ALCOHOL BENCILICO CON HIDRURO SODICO EN DIMETILACETAMIDA PRIMERO, Y CON 1-CLORO-4-(TRIFLUOROMETIL)BENCENO DESPUES, PARA OBTENER BENCIL P-TRIFLUOROMETILFENIL ETER; TRANSFORMAR ESTE EN 4-FENIL-4-(PTRIFLUOROMETILFENOXI)BUTENO POR REACCION CON EL REACTIVO N-BUTILLITIO/TETRAMETILETILENDIAMINA PRIMERO, Y CON BROMURO DE ALILO DESPUES; TRANSFORMAR EL PRODUCTO OBTENIDO EN 3-FENIL-3-(P-TRIFLUOROMETILFENOXI)PROPANAL MEDIANTE REACCION DE OZONOLISIS; TRANSFORMAR EL PRODUCTO OBTENIDO EN EL PRODUCTO (I) DEL TITULO POR REACCION CON METILAMINA EN CONDICIONES DE FORMACION DE LA CORRESPONDIENTE IMINA, Y POSTERIOR REDUCCION IN SITU DE LA IMINA FORMADA, MEDIANTE CIANOBOROHIDRURO SODICO. FINALMENTE EL PRODUCTO (I) SE TRANSFORMA EN SU HIDROCLORURO MEDIANTE LA ADICION DE CLORURO DE HIDROGENO. LA INVENCION TIENE UTILIDAD PARA LA PREPARACION INDUSTRIALMENTE VENTAJOSA DE (I).
ES9501582A 1995-08-03 1995-08-03 Procedimiento de preparacion de n-metil-3-fenil-3- (p-trifluorometilfenoxi)propilamina. Expired - Fee Related ES2103680B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9501582A ES2103680B1 (es) 1995-08-03 1995-08-03 Procedimiento de preparacion de n-metil-3-fenil-3- (p-trifluorometilfenoxi)propilamina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9501582A ES2103680B1 (es) 1995-08-03 1995-08-03 Procedimiento de preparacion de n-metil-3-fenil-3- (p-trifluorometilfenoxi)propilamina.

Publications (2)

Publication Number Publication Date
ES2103680A1 true ES2103680A1 (es) 1997-09-16
ES2103680B1 ES2103680B1 (es) 1998-04-01

Family

ID=8291286

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9501582A Expired - Fee Related ES2103680B1 (es) 1995-08-03 1995-08-03 Procedimiento de preparacion de n-metil-3-fenil-3- (p-trifluorometilfenoxi)propilamina.

Country Status (1)

Country Link
ES (1) ES2103680B1 (es)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES433720A1 (es) * 1974-01-10 1976-12-01 Lilly Co Eli Un procedimiento para preparar los compuestos 3-ariloxi-3- fenilpropilamina.
ES8707175A1 (es) * 1986-06-13 1987-07-16 Inke Sa Procedimiento para la obtencion de la n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina
EP0529842A2 (en) * 1991-08-27 1993-03-03 Teva Pharmaceutical Industries, Ltd. Production of fluoxetine and new intermediates
WO1994000416A1 (en) * 1992-06-26 1994-01-06 Richter Gedeon Vegyészeti Gyár Rt. Preparation of n-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine and acid addition salts thereof
ES2057187T3 (es) * 1989-01-10 1994-10-16 Grato Magnone Procedimiento para la preparacion de clorhidrato de fluoxetina.
ES2062131T3 (es) * 1989-03-03 1994-12-16 Orion Yhtymae Oy Procedimiento para la preparacion de la n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES433720A1 (es) * 1974-01-10 1976-12-01 Lilly Co Eli Un procedimiento para preparar los compuestos 3-ariloxi-3- fenilpropilamina.
ES8707175A1 (es) * 1986-06-13 1987-07-16 Inke Sa Procedimiento para la obtencion de la n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina
ES2057187T3 (es) * 1989-01-10 1994-10-16 Grato Magnone Procedimiento para la preparacion de clorhidrato de fluoxetina.
ES2062131T3 (es) * 1989-03-03 1994-12-16 Orion Yhtymae Oy Procedimiento para la preparacion de la n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales.
EP0529842A2 (en) * 1991-08-27 1993-03-03 Teva Pharmaceutical Industries, Ltd. Production of fluoxetine and new intermediates
WO1994000416A1 (en) * 1992-06-26 1994-01-06 Richter Gedeon Vegyészeti Gyár Rt. Preparation of n-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine and acid addition salts thereof

Also Published As

Publication number Publication date
ES2103680B1 (es) 1998-04-01

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