ES2104370T3 - Derivados de (arilalquilaminobencil)aminopropionamidas sustituidas, su preparacion y utilizacion. - Google Patents

Derivados de (arilalquilaminobencil)aminopropionamidas sustituidas, su preparacion y utilizacion.

Info

Publication number
ES2104370T3
ES2104370T3 ES94911181T ES94911181T ES2104370T3 ES 2104370 T3 ES2104370 T3 ES 2104370T3 ES 94911181 T ES94911181 T ES 94911181T ES 94911181 T ES94911181 T ES 94911181T ES 2104370 T3 ES2104370 T3 ES 2104370T3
Authority
ES
Spain
Prior art keywords
hydrogen
halogen
arylalkylaminobencil
aminopropionamides
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94911181T
Other languages
English (en)
Inventor
Mario Varasi
Philippe Dostert
Paolo Pevarello
Alberto Bonsignori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of ES2104370T3 publication Critical patent/ES2104370T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

EN LA INVENCION SE PRESENTAN NUEVOS COMPUESTOS DE LA FORMULA (I) EN LA QUE N ES UN ENTERO DE 1 A 4; CADA R Y R1, QUE PUEDEN SER IGUALES O DIFERENTES, ES HIDROGENO, HALOGENO, TRIFLUOMETILO O ALCOXI C1-C4; R2 ES HIDROGENO O ALQUILO C1-C4; Y UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS; Y EN LA QUE CUANDO, R ES HIDROGENO, R1 ES HIDROGENO O HALOGENO Y N ES UNO, AL MISMO TIEMPO, ENTONCES R2 ES DISTINTO DE HIDROGENO O METILO; Y DE LA FORMULA (IA) EN LA QUE R3 ES HALOGENO, Y UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS, QUE SON ACTIVOS EN EL SISTEMA NERVIOSO CENTRAL (CNS) Y SE PUEDEN UTILIZAR EN METODOS DE TERAPIA COMO AGENTES ANTIEPILEPTICOS, ANTI-PARKINSON, NEUROPROTECTORES, ANTIDEPRESIVOS, ANTIESPASTICOS E HIPNOTICOS.
ES94911181T 1993-04-01 1994-03-15 Derivados de (arilalquilaminobencil)aminopropionamidas sustituidas, su preparacion y utilizacion. Expired - Lifetime ES2104370T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939306899A GB9306899D0 (en) 1993-04-01 1993-04-01 Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation

Publications (1)

Publication Number Publication Date
ES2104370T3 true ES2104370T3 (es) 1997-10-01

Family

ID=10733226

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94911181T Expired - Lifetime ES2104370T3 (es) 1993-04-01 1994-03-15 Derivados de (arilalquilaminobencil)aminopropionamidas sustituidas, su preparacion y utilizacion.

Country Status (21)

Country Link
US (1) US5449692A (es)
EP (1) EP0648202B1 (es)
JP (1) JP3542600B2 (es)
KR (1) KR950701905A (es)
CN (1) CN1035939C (es)
AT (1) ATE152442T1 (es)
AU (1) AU667169B2 (es)
CA (1) CA2136008C (es)
DE (1) DE69402935T2 (es)
DK (1) DK0648202T3 (es)
ES (1) ES2104370T3 (es)
FI (1) FI945582A7 (es)
GB (1) GB9306899D0 (es)
GR (1) GR3024150T3 (es)
HU (1) HUT70944A (es)
IL (1) IL108970A0 (es)
NZ (1) NZ263183A (es)
PL (1) PL306538A1 (es)
RU (1) RU94046144A (es)
WO (1) WO1994022809A1 (es)
ZA (1) ZA941964B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9515412D0 (en) * 1995-07-27 1995-09-27 Pharmacia Spa 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
IT1283489B1 (it) * 1996-07-23 1998-04-21 Chiesi Farma Spa Ammidi di alfa-amminoacidi,loro preparazione e loro impiego terapeutico
FR2753967B1 (fr) * 1996-09-27 1998-11-27 Sod Conseils Rech Applic Nouveaux derives de la phenoxyethylamine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
EP1032377B1 (en) 1997-11-21 2010-11-17 Purdue Neuroscience Company Substituted 2-aminoacetamides and the use thereof
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
DK1169060T3 (da) * 1999-04-09 2006-01-16 Euro Celtique Sa Natriumkanalblokkerpræparater og anvendelse deraf
DK1423168T3 (da) 2001-09-03 2006-05-15 Newron Pharm Spa Farmaceutisk præparat omfattende gabapentin eller en analog deraf og et alfa-aminoamid og dets analgetiske anvendelse
EP1438956A1 (en) 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
DK1809271T5 (da) * 2004-09-10 2010-12-06 Newron Pharm Spa Anvendelse af (R)-(halogenbenzyloxy)benzylaminopropanamider som natrium- og/eller calciumkanalselektive modulatorer
RU2008120619A (ru) * 2005-10-26 2009-12-10 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) (гетеро)арилы, обладающие антагонистической активностью по отношению к меланинконцентрирующему гормону

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1140748A (en) * 1966-06-23 1969-01-22 Ici Ltd New carboxylic acid derivatives
US4049663A (en) * 1972-06-06 1977-09-20 Allen & Hanburys Limited Ethylene diamine derivatives
DE3010599A1 (de) * 1979-03-22 1980-10-09 Continental Pharma Derivate von glycinamid, deren herstellung und verwendung
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4728668A (en) * 1985-04-16 1988-03-01 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4725619A (en) * 1985-04-16 1988-02-16 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation

Also Published As

Publication number Publication date
CN1035939C (zh) 1997-09-24
RU94046144A (ru) 1996-09-27
GR3024150T3 (en) 1997-10-31
ZA941964B (en) 1994-10-19
EP0648202B1 (en) 1997-05-02
CN1104018A (zh) 1995-06-21
PL306538A1 (en) 1995-04-03
HUT70944A (en) 1995-11-28
DE69402935T2 (de) 1997-11-20
EP0648202A1 (en) 1995-04-19
JPH08504828A (ja) 1996-05-28
AU6377694A (en) 1994-10-24
HU9403809D0 (en) 1995-02-28
GB9306899D0 (en) 1993-05-26
DK0648202T3 (da) 1997-10-27
CA2136008C (en) 2005-06-14
AU667169B2 (en) 1996-03-07
JP3542600B2 (ja) 2004-07-14
US5449692A (en) 1995-09-12
NZ263183A (en) 1996-02-27
DE69402935D1 (de) 1997-06-05
FI945582A0 (fi) 1994-11-28
FI945582L (fi) 1994-11-28
ATE152442T1 (de) 1997-05-15
IL108970A0 (en) 1994-06-24
CA2136008A1 (en) 1994-10-13
FI945582A7 (fi) 1994-11-28
WO1994022809A1 (en) 1994-10-13
KR950701905A (ko) 1995-05-17

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