ES2104612T3 - Procedimiento de preparacion de derivados de sulfonamida de norbornano. - Google Patents
Procedimiento de preparacion de derivados de sulfonamida de norbornano.Info
- Publication number
- ES2104612T3 ES2104612T3 ES90914953T ES90914953T ES2104612T3 ES 2104612 T3 ES2104612 T3 ES 2104612T3 ES 90914953 T ES90914953 T ES 90914953T ES 90914953 T ES90914953 T ES 90914953T ES 2104612 T3 ES2104612 T3 ES 2104612T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- norborn
- represented
- preparation procedure
- sulfonamide derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940124530 sulfonamide Drugs 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 2
- HFFXLYHRNRKAPM-UHFFFAOYSA-N 2,4,5-trichloro-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C(=CC(Cl)=C(Cl)C=2)Cl)=N1 HFFXLYHRNRKAPM-UHFFFAOYSA-N 0.000 abstract 1
- 238000007167 Hofmann rearrangement reaction Methods 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- RPJTXFAFHGMXLE-UHFFFAOYSA-N bicyclo[2.2.1]heptane-4-carboxamide Chemical compound C1CC2CCC1(C(=O)N)C2 RPJTXFAFHGMXLE-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- UMRZSTCPUPJPOJ-KNVOCYPGSA-N norbornane Chemical compound C1C[C@H]2CC[C@@H]1C2 UMRZSTCPUPJPOJ-KNVOCYPGSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003461 sulfonyl halides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE PRESENTA UN PROCESO PARA PREPARAR UN DERIVADO DE SULFONAMIDA DE UN NORBORNAN REPRESENTADO POR LA FORMULA (I), (EN DONDE R'' REPRESENTA CH2OH O COIOH OPCIONALMENTE PROTEGIDO; R2 REPRESENTA FENIL OPCIONALMENTE SUBSTITUIDO; E Y REPRESENTA OXIGENO O METILENO OPCIONALMENTE SUBSTITUIDO), QUE COMPRENDE EL TRATAMIENTO BAJO CONDICIONES DE REACCION DE REORDENAMIENTO DE HOFMANN DE UN CARBOXAMIDO DE NORBORNAN REPRESENTADO POR LA FORMULA (II), (EN DONDE R REPRESENTA COOR1 O CH2OH OPCIONALMENTE PROTEGIDO, R1 REPRESENTA HIDROGENO O UN GRUPO PARA LA FORMACION DE ESTER; E Y ES SEGUN SE HA DEFINIDO ANTERIORMENTE); Y LA REACCION DEL COMPUESTO RESULTANTE CON UN ALURO DE SULFONIL REPRESENTADO POR LA FORMULA (III), (EN LA QUE R2 ES SEGUN SE HA DEFINIDO ANTERIORMENTE; Y X REPRESENTA UN HALOGENO).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27442889 | 1989-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2104612T3 true ES2104612T3 (es) | 1997-10-16 |
Family
ID=17541537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90914953T Expired - Lifetime ES2104612T3 (es) | 1989-10-18 | 1990-10-16 | Procedimiento de preparacion de derivados de sulfonamida de norbornano. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5124462A (es) |
| EP (1) | EP0557519B1 (es) |
| JP (1) | JP2828334B2 (es) |
| KR (1) | KR0137673B1 (es) |
| AT (1) | ATE154005T1 (es) |
| DE (1) | DE69030884T2 (es) |
| DK (1) | DK0557519T3 (es) |
| ES (1) | ES2104612T3 (es) |
| GR (1) | GR3024010T3 (es) |
| WO (1) | WO1991005765A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3431204B2 (ja) * | 1993-04-22 | 2003-07-28 | 塩野義製薬株式会社 | ノルボルナン型エステル・ヒドロラーゼ |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ218115A (en) * | 1985-11-18 | 1990-02-26 | Shionogi & Co | Bicyclic sulphonamides and pharmaceutical compositions |
| DE3720760A1 (de) * | 1987-06-24 | 1989-01-05 | Bayer Ag | Norbornan- und norbornensulfonamide, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel |
| JP2756689B2 (ja) * | 1989-02-20 | 1998-05-25 | 塩野義製薬株式会社 | 置換ヘキセン酸誘導体 |
-
1990
- 1990-10-16 WO PCT/JP1990/001330 patent/WO1991005765A1/ja not_active Ceased
- 1990-10-16 DK DK90914953.6T patent/DK0557519T3/da active
- 1990-10-16 AT AT90914953T patent/ATE154005T1/de not_active IP Right Cessation
- 1990-10-16 DE DE69030884T patent/DE69030884T2/de not_active Expired - Fee Related
- 1990-10-16 EP EP90914953A patent/EP0557519B1/en not_active Expired - Lifetime
- 1990-10-16 US US07/690,925 patent/US5124462A/en not_active Expired - Fee Related
- 1990-10-16 ES ES90914953T patent/ES2104612T3/es not_active Expired - Lifetime
- 1990-10-17 JP JP2279806A patent/JP2828334B2/ja not_active Expired - Fee Related
-
1991
- 1991-06-18 KR KR91700627A patent/KR0137673B1/ko not_active Expired - Fee Related
-
1997
- 1997-07-08 GR GR970401665T patent/GR3024010T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE154005T1 (de) | 1997-06-15 |
| JPH03204852A (ja) | 1991-09-06 |
| JP2828334B2 (ja) | 1998-11-25 |
| EP0557519A1 (en) | 1993-09-01 |
| KR920701139A (ko) | 1992-08-11 |
| WO1991005765A1 (fr) | 1991-05-02 |
| US5124462A (en) | 1992-06-23 |
| GR3024010T3 (en) | 1997-10-31 |
| DE69030884T2 (de) | 1997-12-18 |
| KR0137673B1 (en) | 1998-05-01 |
| EP0557519B1 (en) | 1997-06-04 |
| EP0557519A4 (en) | 1992-02-20 |
| DK0557519T3 (da) | 1997-06-23 |
| DE69030884D1 (de) | 1997-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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