ES2104853T3 - Composiciones antitumorales y procedimiento de tratamiento. - Google Patents
Composiciones antitumorales y procedimiento de tratamiento.Info
- Publication number
- ES2104853T3 ES2104853T3 ES92311031T ES92311031T ES2104853T3 ES 2104853 T3 ES2104853 T3 ES 2104853T3 ES 92311031 T ES92311031 T ES 92311031T ES 92311031 T ES92311031 T ES 92311031T ES 2104853 T3 ES2104853 T3 ES 2104853T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- halo
- compounds
- antitumoral
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/60—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/811,483 US5234955A (en) | 1991-12-20 | 1991-12-20 | Antitumor compositions and methods of treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2104853T3 true ES2104853T3 (es) | 1997-10-16 |
Family
ID=25206668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92311031T Expired - Lifetime ES2104853T3 (es) | 1991-12-20 | 1992-12-03 | Composiciones antitumorales y procedimiento de tratamiento. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5234955A (de) |
| EP (1) | EP0550157B1 (de) |
| JP (1) | JPH05345755A (de) |
| AT (1) | ATE155776T1 (de) |
| CA (1) | CA2084469A1 (de) |
| DE (1) | DE69221106T2 (de) |
| DK (1) | DK0550157T3 (de) |
| ES (1) | ES2104853T3 (de) |
| GR (1) | GR3024986T3 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| EP0929540A4 (de) * | 1996-10-04 | 2001-12-12 | Lilly Co Eli | Antitumor-zusamensetzungen und behandlungsverfahren |
| TW486463B (en) * | 1997-10-04 | 2002-05-11 | Dev Center Biotechnology | Guanidine derivatives, method for making the same, and anti-cancer composition containing the same |
| US6342219B1 (en) | 1999-04-28 | 2002-01-29 | Board Of Regents, The University Of Texas System | Antibody compositions for selectively inhibiting VEGF |
| US6703020B1 (en) | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| DK1399128T3 (da) * | 2001-06-15 | 2007-01-08 | Innovent Technology Ltd | Sammensætning til behandling af sygdomme, der angriber dyrs hove/klove |
| WO2011009059A2 (en) * | 2009-07-17 | 2011-01-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of treating or preventing cancer |
| US9341238B2 (en) | 2012-06-15 | 2016-05-17 | Gkn Driveline North America, Inc. | Power transfer unit straddle mount ring gear disconnect |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3083207A (en) * | 1963-03-26 | Indolinesulfonylureas | ||
| DE1144259B (de) * | 1956-05-29 | 1963-02-28 | Hoechst Ag | Verfahren zur Herstellung von Sulfonylharnstoffen |
| DE1159937B (de) * | 1960-06-29 | 1963-12-27 | Heyden Chem Fab | Verfahren zur Herstellung von Hydrindensulfonylharnstoffen |
| US3097242A (en) * | 1960-06-29 | 1963-07-09 | Olin Mathieson | Hydrindene sulfonylureas |
| DE1240866B (de) * | 1961-06-29 | 1967-05-24 | Heyden Chem Fab | Verfahren zur Herstellung von Indolin-6-sulfonylharnstoffen |
| US3102121A (en) * | 1961-06-29 | 1963-08-27 | Olin Mathieson | Novel cumaransulfonylureas and 2,3-dihydrothionaphthenesulfonylureas |
| BE634577A (de) * | 1962-04-11 | |||
| US3849110A (en) * | 1963-01-07 | 1974-11-19 | Lilly Co Eli | Herbicidal method employing aryl-sulfonylureas or salts thereof |
| US3736122A (en) * | 1969-04-10 | 1973-05-29 | C Tung | Method of controlling plant growth |
| IL69621A0 (en) * | 1982-09-02 | 1983-12-30 | Duphar Int Res | Pharmaceutical compositions having antitumor activity,comprising certain phenylurea derivatives |
| CA1208561A (en) * | 1984-01-19 | 1986-07-29 | Marius S. Brouwer | Pharmaceutical compositions containing benzoylurea compounds |
| US4845128A (en) * | 1984-06-27 | 1989-07-04 | Eli Lilly And Company | N([(4-trifluoromethylphenyl)amino]carbonyl)benzene sulfonamides |
| IL80032A (en) * | 1985-09-23 | 1992-07-15 | Lilly Co Eli | Anti-tumor phenyl-aminocarbonylsulfonamides,their preparation and pharmaceutical compositions containing them |
| CA1331464C (en) * | 1987-05-12 | 1994-08-16 | Eli Lilly And Company | Anti-tumor method and compounds |
-
1991
- 1991-12-20 US US07/811,483 patent/US5234955A/en not_active Expired - Fee Related
-
1992
- 1992-12-03 AT AT92311031T patent/ATE155776T1/de active
- 1992-12-03 EP EP92311031A patent/EP0550157B1/de not_active Expired - Lifetime
- 1992-12-03 DK DK92311031.6T patent/DK0550157T3/da active
- 1992-12-03 DE DE69221106T patent/DE69221106T2/de not_active Expired - Fee Related
- 1992-12-03 ES ES92311031T patent/ES2104853T3/es not_active Expired - Lifetime
- 1992-12-03 CA CA002084469A patent/CA2084469A1/en not_active Abandoned
- 1992-12-08 JP JP4327815A patent/JPH05345755A/ja active Pending
-
1993
- 1993-03-26 US US08/037,954 patent/US5354778A/en not_active Expired - Fee Related
-
1997
- 1997-10-09 GR GR970402629T patent/GR3024986T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3024986T3 (en) | 1998-01-30 |
| DE69221106T2 (de) | 1997-12-11 |
| DK0550157T3 (da) | 1997-12-01 |
| EP0550157B1 (de) | 1997-07-23 |
| US5354778A (en) | 1994-10-11 |
| ATE155776T1 (de) | 1997-08-15 |
| US5234955A (en) | 1993-08-10 |
| JPH05345755A (ja) | 1993-12-27 |
| EP0550157A1 (de) | 1993-07-07 |
| DE69221106D1 (de) | 1997-08-28 |
| CA2084469A1 (en) | 1993-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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