ES2105312T3 - Procedimiento quimico de preparacion de un aminodiol opticamente activo. - Google Patents

Procedimiento quimico de preparacion de un aminodiol opticamente activo.

Info

Publication number
ES2105312T3
ES2105312T3 ES93919103T ES93919103T ES2105312T3 ES 2105312 T3 ES2105312 T3 ES 2105312T3 ES 93919103 T ES93919103 T ES 93919103T ES 93919103 T ES93919103 T ES 93919103T ES 2105312 T3 ES2105312 T3 ES 2105312T3
Authority
ES
Spain
Prior art keywords
pct
beta
preparation
optically active
chemical procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93919103T
Other languages
English (en)
Inventor
David Joszef Tapolczay
Clive Alwin Meerholz
John Peter Turnbull
Bernard Charles Halter
Mark Brian Schilling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2105312T3 publication Critical patent/ES2105312T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/74—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

SE SOLICITA UN PROCESO PARA PREPARAR [1S(1ALFA,2BETA, 4BETA)]-AAMINO-2-HIDROXIMETIL-1-CICLOPENTANOL A PARTIR DEL ESTER DEL ACIDO CIS-4-((R)-BENZOILAMINO)-2-CICLOPENTENOCARBOXILICO, EN CINCO PASO. LA INVENCION DESCRIBE TAMBIEN UN NUMERO DE NUEVOS INTERMEDIOS UTILES EN LA SINTESIS DE [1S(1ALFA, 2BETA, 4BETA)]-4-AMINO-2-HIDROXIMETIL-1CICLOPENTANOL.
ES93919103T 1992-08-21 1993-08-19 Procedimiento quimico de preparacion de un aminodiol opticamente activo. Expired - Lifetime ES2105312T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929217823A GB9217823D0 (en) 1992-08-21 1992-08-21 Chemical process

Publications (1)

Publication Number Publication Date
ES2105312T3 true ES2105312T3 (es) 1997-10-16

Family

ID=10720746

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93919103T Expired - Lifetime ES2105312T3 (es) 1992-08-21 1993-08-19 Procedimiento quimico de preparacion de un aminodiol opticamente activo.

Country Status (11)

Country Link
US (1) US5659075A (es)
EP (1) EP0655994B1 (es)
JP (1) JP3296560B2 (es)
AT (1) ATE154589T1 (es)
AU (1) AU4950193A (es)
DE (1) DE69311725T2 (es)
DK (1) DK0655994T3 (es)
ES (1) ES2105312T3 (es)
GB (1) GB9217823D0 (es)
GR (1) GR3024069T3 (es)
WO (1) WO1994004486A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK285229B6 (sk) 1997-05-13 2006-09-07 Lonza Ag Spôsob výroby derivátov (1R,4S)- alebo (1S,4R)-1-amino-4- (hydroxymetyl)-2-cyklopenténu a enantioméru (1R,4S)-N-butyryl-1- amino-4-(hydroxymetyl)-2-cyklopenténu

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474093A (en) * 1966-05-03 1969-10-21 American Home Prod Enamine adducts of n-acyloxy-n-acylaminoacetanilide
DE2252674C3 (de) * 1972-10-27 1981-02-05 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Aldehyden aus Olefinen
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides

Also Published As

Publication number Publication date
AU4950193A (en) 1994-03-15
JPH08500583A (ja) 1996-01-23
EP0655994A1 (en) 1995-06-07
WO1994004486A1 (en) 1994-03-03
DE69311725T2 (de) 1997-10-30
DK0655994T3 (da) 1997-12-29
EP0655994B1 (en) 1997-06-18
JP3296560B2 (ja) 2002-07-02
DE69311725D1 (de) 1997-07-24
GR3024069T3 (en) 1997-10-31
ATE154589T1 (de) 1997-07-15
US5659075A (en) 1997-08-19
GB9217823D0 (en) 1992-10-07

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