ES2105633T3 - Derivados de pirimidinona condensada a heterociclos nitrogenados con actividad antagonista de a ii. - Google Patents

Derivados de pirimidinona condensada a heterociclos nitrogenados con actividad antagonista de a ii.

Info

Publication number
ES2105633T3
ES2105633T3 ES94905660T ES94905660T ES2105633T3 ES 2105633 T3 ES2105633 T3 ES 2105633T3 ES 94905660 T ES94905660 T ES 94905660T ES 94905660 T ES94905660 T ES 94905660T ES 2105633 T3 ES2105633 T3 ES 2105633T3
Authority
ES
Spain
Prior art keywords
pirimidinone
condensed
derivatives
antagonist activity
nitrogenated heterocycles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94905660T
Other languages
English (en)
Inventor
Aldo Salimbeni
Davide Poma
Anna Renzetti
Carlo Scolastico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Luso Farmaco dItalia SpA
Original Assignee
Istituto Luso Farmaco dItalia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Luso Farmaco dItalia SpA filed Critical Istituto Luso Farmaco dItalia SpA
Application granted granted Critical
Publication of ES2105633T3 publication Critical patent/ES2105633T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

COMPUESTOS DE LAS FORMULAS (I) Y (I`), EN LAS QUE A, B, C, R, R{SUB,8} Y Z TIENEN SUS SIGNIFICADOS DEFINIDOS EN LA ESPECIFICACION, TIENEN ACTIVIDAD ANTAGONISTICA II ANGIOTESIN.
ES94905660T 1993-01-22 1994-01-20 Derivados de pirimidinona condensada a heterociclos nitrogenados con actividad antagonista de a ii. Expired - Lifetime ES2105633T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI930100A IT1263804B (it) 1993-01-22 1993-01-22 Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista

Publications (1)

Publication Number Publication Date
ES2105633T3 true ES2105633T3 (es) 1997-10-16

Family

ID=11364728

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94905660T Expired - Lifetime ES2105633T3 (es) 1993-01-22 1994-01-20 Derivados de pirimidinona condensada a heterociclos nitrogenados con actividad antagonista de a ii.

Country Status (7)

Country Link
US (1) US5804583A (es)
EP (1) EP0680480B1 (es)
AU (1) AU5969394A (es)
DE (1) DE69404627T2 (es)
ES (1) ES2105633T3 (es)
IT (1) IT1263804B (es)
WO (1) WO1994017067A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10050661A1 (de) 2000-10-13 2002-04-18 Gruenenthal Gmbh Substituierte 3,4-Dihydro-pyrimido[1,2-a]pyrimidine und 3,4-Dihydro-pyrazino[1,2-a]pyrimidine
GEP20125574B (en) * 2008-01-11 2012-07-10 Glenmark Pharmaceuticals Sa Fused pyrimidine derivatives as trpv3 modulators
US8119647B2 (en) * 2008-04-23 2012-02-21 Glenmark Pharmaceuticals S.A. Fused pyrimidineone compounds as TRPV3 modulators
ES2433225T3 (es) 2009-01-30 2013-12-10 Takeda Pharmaceutical Company Limited Compuesto con anillos condensados y uso del mismo
NZ623384A (en) * 2009-10-16 2016-06-24 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
CA2020073A1 (en) * 1989-07-03 1991-01-04 Eric E. Allen Substituted quinazolinones as angiotensin ii antagonists
EP0435827A3 (en) * 1989-12-28 1991-11-13 Ciba-Geigy Ag Diaza compounds
WO1991015209A1 (en) * 1990-03-30 1991-10-17 Merck & Co., Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines
US5250521A (en) * 1990-12-07 1993-10-05 Merck & Co., Inc. Substituted pyrazolopyrimidines as angiotensin II antagonists
FR2678618B1 (fr) * 1991-07-05 1993-11-05 Upsa Laboratoires Nouveaux derives de triazolo pyrimidine antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.
FR2687676B1 (fr) * 1992-02-24 1994-07-08 Union Pharma Scient Appl Nouveaux derives de polyazaindenes antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.
US5387747A (en) * 1992-02-24 1995-02-07 Laboratoires Upsa Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present
FR2687677B1 (fr) * 1992-02-24 1996-10-11 Union Pharma Scient Appl Nouveaux derives de polyazaindenes antagonistes des recepteurs a l'angiotensine ii ; leurs procedes de preparation, compositions pharmaceutiques les contenant.

Also Published As

Publication number Publication date
EP0680480A1 (en) 1995-11-08
ITMI930100A0 (it) 1993-01-22
EP0680480B1 (en) 1997-07-30
WO1994017067A1 (en) 1994-08-04
IT1263804B (it) 1996-09-03
US5804583A (en) 1998-09-08
DE69404627T2 (de) 1998-01-22
DE69404627D1 (de) 1997-09-04
AU5969394A (en) 1994-08-15
ITMI930100A1 (it) 1994-07-22

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