ES2105975A1 - Procedimiento de purificacion de aminoacidos glicosilados aptos para la sintesis en fase solida de glicopeptidos. - Google Patents
Procedimiento de purificacion de aminoacidos glicosilados aptos para la sintesis en fase solida de glicopeptidos.Info
- Publication number
- ES2105975A1 ES2105975A1 ES09501697A ES9501697A ES2105975A1 ES 2105975 A1 ES2105975 A1 ES 2105975A1 ES 09501697 A ES09501697 A ES 09501697A ES 9501697 A ES9501697 A ES 9501697A ES 2105975 A1 ES2105975 A1 ES 2105975A1
- Authority
- ES
- Spain
- Prior art keywords
- amino acids
- glycopeptides
- purification
- solid
- glycosylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 102000002068 Glycopeptides Human genes 0.000 title abstract 4
- 108010015899 Glycopeptides Proteins 0.000 title abstract 4
- 238000000746 purification Methods 0.000 title abstract 4
- 238000010532 solid phase synthesis reaction Methods 0.000 title abstract 2
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008367 deionised water Substances 0.000 abstract 1
- 229910021641 deionized water Inorganic materials 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000002337 glycosamines Chemical class 0.000 abstract 1
- 238000005858 glycosidation reaction Methods 0.000 abstract 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO DE PURIFICACION DE AMINOACIDOS GLICOSILADOS APTOS PARA LA SINTESIS EN FASE SOLIDA DE GLICOPEPTIDOS. SE PROPONE UN PROCEDIMIENTO DE PURIFICACION DE AMINOACIDOS GLICOSILADOS APTOS PARA SU UTILIZACION EN LA SINTESIS DE GLICOPEPTIDOS MEDIANTE LA TECNOLOGIA EN FASE SOLIDA. DURANTE LAS REACCIONES DE GLICOSIDACION DE AMINOACIDOS SE OBTIENEN CONJUGADOS ENTRE AMINOACIDOS Y AZUCAR (SINTONES GLICOSILADOS) QUE ES NECESARIO PURIFICAR. PARA ELLO SE UTILIZA SIMPLE AGUA DESIONIZADA EN LA PURIFICACION POR CROMATOGRAFIA EN FASE REVERSA A NIVEL PREPARATIVO. EL PROCEDIMIENTO DE LA INVENCION PERMITE DISPONER DE CANTIDADES DEL ORDEN DE GRAMOS DE LOS MENCIONADOS SINTONES GLICOSILADOS PURIFICADOS LO QUE ES CRUCIAL PARA EL DESARROLLO DE GLICOPEPTIDOS CON ACTIVIDAD BIOLOGICA COMO POSIBLES FARMACOS. POR TANTO EL PROCEDIMIENTO ES DE INTERES PRINCIPALMENTE PARA EL SECTOR FARMACEUTICO ASI COMO PARA EL MERCADO DE DERIVADOS PARA LA INVESTIGACION SOBRE COMPUESTOS BIOACTIVOS.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9501697A ES2105975B1 (es) | 1995-08-28 | 1995-08-28 | Procedimiento de purificacion de aminoacidos glicosilados aptos para la sintesis en fase solida de glicopeptidos. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9501697A ES2105975B1 (es) | 1995-08-28 | 1995-08-28 | Procedimiento de purificacion de aminoacidos glicosilados aptos para la sintesis en fase solida de glicopeptidos. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2105975A1 true ES2105975A1 (es) | 1997-10-16 |
| ES2105975B1 ES2105975B1 (es) | 1998-06-01 |
Family
ID=8291453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9501697A Expired - Fee Related ES2105975B1 (es) | 1995-08-28 | 1995-08-28 | Procedimiento de purificacion de aminoacidos glicosilados aptos para la sintesis en fase solida de glicopeptidos. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2105975B1 (es) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2009274A6 (es) * | 1988-05-13 | 1989-09-16 | Consejo Superior Investigacion | Sintesis de glicoencefalinas derivadas de hyp5. |
-
1995
- 1995-08-28 ES ES9501697A patent/ES2105975B1/es not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2009274A6 (es) * | 1988-05-13 | 1989-09-16 | Consejo Superior Investigacion | Sintesis de glicoencefalinas derivadas de hyp5. |
Non-Patent Citations (1)
| Title |
|---|
| SMITH, K.D. et al. "Enzyme Degradation, High-Performance Liquid Chromatography and Liquid Secondary-Ion Mass Spectrometry in the Analysis of Glycoproteins". BIOMEDICAL CHROMATOGRAPHY. 1990. Vol. 4, n‘ 6, pßginas 261-266 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2105975B1 (es) | 1998-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19971016 Kind code of ref document: A1 Effective date: 19971016 |
|
| FD1A | Patent lapsed |
Effective date: 20040830 |