ES2107431T3 - Agentes con accion selectiva sobre los receptores de la adenosina. - Google Patents

Agentes con accion selectiva sobre los receptores de la adenosina.

Info

Publication number
ES2107431T3
ES2107431T3 ES91104668T ES91104668T ES2107431T3 ES 2107431 T3 ES2107431 T3 ES 2107431T3 ES 91104668 T ES91104668 T ES 91104668T ES 91104668 T ES91104668 T ES 91104668T ES 2107431 T3 ES2107431 T3 ES 2107431T3
Authority
ES
Spain
Prior art keywords
adenosine
agents
adenosine receptors
selective action
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91104668T
Other languages
English (en)
Inventor
Norton P Peet
Nelsen L Lentz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2107431T3 publication Critical patent/ES2107431T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCUBREN, DERIVADOS DE XANTINA QUE SON SELECTIVAMENTE RECEPTORES DE ADENOSINA Y QUE ACTUAN EN GENERAL COMO ANTAGONISTAS DE ADENOSINA. SE CONOCE POR ESTUDIOS "IN VITRO" QUE EFECTOS ESPECIFICOS FISIOLOGICOS SE PUEDEN DISTINGUIR COMO UN RESULTADO DE ESTA SELECTIVIDAD Y QUE LA ACTIVIDAD RECEPTORA DE ADENOSINA "IN VITRO" SE CORELACIONA CON LA ACTIVIDAD RECEPTORA DE ADENOSINA "IN VIVO". SE PUEDEN PREPARAR PREPARACIONES FARMACEUTICAS DE ESTOS COMPUESTOS EN BASE A LA ACTIVIDAD DE ENLACE SELECTIVA DE LOS COMPUESTOS DESCUBIERTOS AQUI QUE REALZARAN CIERTOS EFECTOS FISIOLOGICOS MIENTRAS MINIMIZAN OTROS, TAL COMO DISMINUIR LA PRESION SANGUINEA SIN DISMINUIR LA PRODUCCION CARDIACA.
ES91104668T 1990-03-26 1991-03-25 Agentes con accion selectiva sobre los receptores de la adenosina. Expired - Lifetime ES2107431T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/499,111 US5047534A (en) 1990-03-26 1990-03-26 Selective adenosine receptor agents

Publications (1)

Publication Number Publication Date
ES2107431T3 true ES2107431T3 (es) 1997-12-01

Family

ID=23983864

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91104668T Expired - Lifetime ES2107431T3 (es) 1990-03-26 1991-03-25 Agentes con accion selectiva sobre los receptores de la adenosina.

Country Status (22)

Country Link
US (1) US5047534A (es)
EP (1) EP0449175B1 (es)
JP (1) JP3181305B2 (es)
KR (1) KR100195368B1 (es)
CN (1) CN1032815C (es)
AR (1) AR247887A1 (es)
AT (1) ATE156130T1 (es)
AU (1) AU632914B2 (es)
CA (1) CA2038747C (es)
DE (1) DE69127010T2 (es)
DK (1) DK0449175T3 (es)
ES (1) ES2107431T3 (es)
FI (1) FI98461C (es)
GR (1) GR3025135T3 (es)
HU (1) HU208824B (es)
IE (1) IE910982A1 (es)
IL (1) IL97656A (es)
NO (1) NO177591C (es)
NZ (1) NZ237484A (es)
PH (1) PH27511A (es)
PT (1) PT97133B (es)
ZA (1) ZA912038B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208240A (en) * 1991-03-12 1993-05-04 Merrell Dow Pharmaceuticals Inc. 8-substituted purines as selective adenosine receptor agents
CA2116967C (en) * 1992-07-08 2003-08-19 Fumio Suzuki Antidepressants
CN1041418C (zh) * 1993-02-26 1998-12-30 默里尔多药物公司 用作腺苷a1受体拮抗剂的黄嘌呤衍生物
AU6781194A (en) * 1993-05-03 1994-11-21 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists
JPH08509977A (ja) * 1993-05-06 1996-10-22 メレルダウファーマスーティカルズ インコーポレイテッド 選択的アデノシン受容体剤としての８−置換キサンチン類
US5629298A (en) * 1995-03-13 1997-05-13 University Of Massachusetts Medical Center Adenosine as a positive inotrop in the compromised heart
GB9819382D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
US6258794B1 (en) 1999-12-14 2001-07-10 The Mclean Hospital Corporation Treatment of mental conditions including depression
CN1787821A (zh) * 2003-06-10 2006-06-14 协和发酵工业株式会社 一种治疗焦虑症的方法
WO2007036491A1 (de) * 2005-09-30 2007-04-05 Basf Aktiengesellschaft Verfahren zur herstellung von alpha-substituierten carbonsäuren
US7592461B2 (en) * 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1435916A (en) * 1972-05-11 1976-05-19 Beecham Group Ltd Pharmaceutical weight-reducing compositions
SE416810C (sv) * 1977-10-14 1982-07-19 Draco Ab Forfarande for framstellning av xantinderivat med antiallergisk aktivitet
JPS57198544A (en) * 1981-05-28 1982-12-06 Sony Corp Manufacture of magnetic recording medium
US4593095A (en) * 1983-02-18 1986-06-03 The Johns Hopkins University Xanthine derivatives
US4772607A (en) * 1986-05-20 1988-09-20 Warner-Lambert Company Dialkenyl derivatives of xanthine, pharmaceutical compositions and methods of use therefor
US4783530A (en) * 1986-11-13 1988-11-08 Marion Laboratories, Inc. 8-arylxanthines
DE8817122U1 (de) * 1988-12-22 1993-02-04 Boehringer Ingelheim Kg, 55218 Ingelheim Neue Xanthinderivate mit Adenosinantogenistischer Wirkung

Also Published As

Publication number Publication date
JPH04221384A (ja) 1992-08-11
FI911420A0 (fi) 1991-03-25
FI98461C (fi) 1997-06-25
CN1055181A (zh) 1991-10-09
KR910016752A (ko) 1991-11-05
HUT56570A (en) 1991-09-30
AR247887A1 (es) 1995-04-28
FI911420L (fi) 1991-09-27
IE910982A1 (en) 1991-10-09
GR3025135T3 (en) 1998-02-27
DE69127010T2 (de) 1997-11-13
IL97656A (en) 1996-06-18
HU208824B (en) 1994-01-28
DE69127010D1 (de) 1997-09-04
NO911200D0 (no) 1991-03-25
US5047534A (en) 1991-09-10
KR100195368B1 (ko) 1999-06-15
ATE156130T1 (de) 1997-08-15
AU632914B2 (en) 1993-01-14
NO177591C (no) 1995-10-18
CN1032815C (zh) 1996-09-18
JP3181305B2 (ja) 2001-07-03
FI98461B (fi) 1997-03-14
NZ237484A (en) 1993-10-26
PT97133A (pt) 1991-12-31
EP0449175B1 (en) 1997-07-30
DK0449175T3 (da) 1998-02-23
NO177591B (no) 1995-07-10
NO911200L (no) 1991-09-27
PT97133B (pt) 1998-07-31
CA2038747C (en) 2002-05-28
EP0449175A2 (en) 1991-10-02
AU7353791A (en) 1991-10-03
PH27511A (en) 1993-08-18
IL97656A0 (en) 1992-06-21
ZA912038B (en) 1991-12-24
CA2038747A1 (en) 1991-09-27
EP0449175A3 (en) 1993-01-20

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