ES2110186T3 - Agentes antitromboticos tripeptidicos. - Google Patents

Agentes antitromboticos tripeptidicos.

Info

Publication number
ES2110186T3
ES2110186T3 ES94306667T ES94306667T ES2110186T3 ES 2110186 T3 ES2110186 T3 ES 2110186T3 ES 94306667 T ES94306667 T ES 94306667T ES 94306667 T ES94306667 T ES 94306667T ES 2110186 T3 ES2110186 T3 ES 2110186T3
Authority
ES
Spain
Prior art keywords
tripeptidic
antithrombotic agents
inhibitors
perhydroisoquinolin
prolinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94306667T
Other languages
English (en)
Inventor
Paul David Gesellchen
Robert Theodore Shuman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2110186T3 publication Critical patent/ES2110186T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

ESTA INVENCION PROPORCIONA ALDEHIDO (1R, 4AR, 8AR)-1,2,3,4,5,6,7,8 PERHIDROISOQUINOLIN-1-CARBONIL-(L)-PROLINIL-(L)-ARGININA Y SALES Y SOLVATOS DEL MISMO FARMACEUTICAMENTE ACEPTABLES, FORMULACIONES FARMACEUTICAS QUE CONTIENEN DICHOS COMPUESTOS Y METODOS DE SU USO COMO INHIBIDORES DE TROMBINA, INHIBIDORES DE COAGULACION Y AGENTES DE ENFERMEDADES TROMBOEMBOLICAS.
ES94306667T 1993-09-14 1994-09-12 Agentes antitromboticos tripeptidicos. Expired - Lifetime ES2110186T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/121,134 US5430023A (en) 1990-09-28 1993-09-14 Tripeptide antithrombotic agents

Publications (1)

Publication Number Publication Date
ES2110186T3 true ES2110186T3 (es) 1998-02-01

Family

ID=22394776

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94306667T Expired - Lifetime ES2110186T3 (es) 1993-09-14 1994-09-12 Agentes antitromboticos tripeptidicos.

Country Status (31)

Country Link
US (1) US5430023A (es)
EP (1) EP0643073B1 (es)
JP (1) JPH07149791A (es)
KR (1) KR100312388B1 (es)
CN (1) CN1055698C (es)
AT (1) ATE160574T1 (es)
AU (1) AU674773B2 (es)
BR (1) BR9403542A (es)
CA (1) CA2131982C (es)
CO (1) CO4290364A1 (es)
CY (1) CY2072B1 (es)
CZ (1) CZ286139B6 (es)
DE (1) DE69407006T2 (es)
DK (1) DK0643073T3 (es)
ES (1) ES2110186T3 (es)
FI (1) FI944231L (es)
GR (1) GR3026115T3 (es)
HU (1) HU220620B1 (es)
IL (1) IL110933A (es)
MY (1) MY112879A (es)
NO (1) NO310240B1 (es)
NZ (1) NZ264438A (es)
PE (1) PE43695A1 (es)
PH (1) PH31655A (es)
PL (1) PL176448B1 (es)
RU (1) RU2105010C1 (es)
SI (1) SI0643073T1 (es)
TW (1) TW275622B (es)
UA (1) UA32556C2 (es)
YU (1) YU54194A (es)
ZA (1) ZA947015B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08501057A (ja) * 1992-03-04 1996-02-06 ヂョヂセルクタトー インテーゼット カーエフテー 新規な抗凝結因子ペプチド誘導体及びそれを含有する製薬学的組成物及びその製造方法
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
EP0748333A4 (en) * 1994-03-04 2000-05-10 Lilly Co Eli ANTITHROMBOTIC SUBSTANCES
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5691356A (en) * 1994-03-21 1997-11-25 Bristol-Myers Squibb Company Disubstituted heterocyclic thrombin inhibitors
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US6022861A (en) * 1995-06-07 2000-02-08 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US5721214A (en) * 1995-06-07 1998-02-24 Cor Therapeutics, Inc. Inhibitors of factor Xa
US5919765A (en) * 1995-06-07 1999-07-06 Cor Therapeutics, Inc. Inhibitors of factor XA
US6046169A (en) * 1995-06-07 2000-04-04 Cor Therapeutics, Inc. Inhibitors of factor XA
US6069130A (en) 1995-06-07 2000-05-30 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US6245743B1 (en) 1996-06-05 2001-06-12 Cor Therapeutics, Inc. Inhibitors of factor Xa
JP3539607B2 (ja) * 1997-02-19 2004-07-07 シャープ株式会社 空気調和機の運転制御システム
JP2001525823A (ja) 1997-05-15 2001-12-11 イーライ・リリー・アンド・カンパニー 抗血栓化合物
US6903075B1 (en) 1997-05-29 2005-06-07 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
AU8059598A (en) * 1998-06-11 1999-12-30 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
SE9802973D0 (sv) * 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
US6172081B1 (en) 1999-06-24 2001-01-09 Novartis Ag Tetrahydroisoquinoline 3-carboxamide derivatives
CA2475761C (en) * 2002-02-11 2011-07-12 Gold-T Tech, Inc. An implantable device which provides high frequency ultrasound energy to provide acoustical streaming to prevent thrombus formation
US7205315B2 (en) 2003-09-27 2007-04-17 Sanofi-Aventis Deutschland Gmbh Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases
RU2377246C2 (ru) * 2007-06-08 2009-12-27 Государственное учреждение гематологический научный центр Российской академии медицинских наук (ГУ ГНЦ РАМН) Синтетическое производное пептида, проявляющее антикоагулянтную активность
CN102391360B (zh) * 2011-11-02 2013-07-03 东南大学 一种抗血栓和血小板聚集的小肽
KR102388531B1 (ko) * 2021-07-07 2022-04-21 이재호 특장차용 스마트 유압 시스템

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU177098B (en) * 1979-01-04 1981-07-28 Gyogyszerkutato Intezet Process for producing new peptidyl-n-carboxy-l-arginin-a
HU178398B (en) * 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
DE3827415A1 (de) * 1988-08-12 1990-02-15 Behringwerke Ag Peptidderivate, verfahren zu ihrer herstellung und ihre verwendung
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents
US5250660A (en) * 1991-11-12 1993-10-05 Eli Lilly And Company Peptide purification process
US5252566A (en) * 1991-11-12 1993-10-12 Eli Lilly And Company Antithrombotic agents

Also Published As

Publication number Publication date
CZ286139B6 (cs) 2000-01-12
GR3026115T3 (en) 1998-05-29
CN1106819A (zh) 1995-08-16
HU220620B1 (hu) 2002-03-28
KR100312388B1 (ko) 2001-12-28
DE69407006T2 (de) 1998-04-16
IL110933A (en) 1998-12-27
NZ264438A (en) 1996-06-25
CY2072B1 (en) 1998-09-11
RU2105010C1 (ru) 1998-02-20
MY112879A (en) 2001-10-31
CZ222094A3 (en) 1995-03-15
FI944231A0 (fi) 1994-09-13
SI0643073T1 (en) 1998-08-31
DE69407006D1 (de) 1998-01-08
CA2131982A1 (en) 1995-03-15
FI944231A7 (fi) 1995-03-15
NO943402D0 (no) 1994-09-13
TW275622B (es) 1996-05-11
ZA947015B (en) 1996-03-12
US5430023A (en) 1995-07-04
PE43695A1 (es) 1995-12-09
HUT67849A (en) 1995-05-29
CA2131982C (en) 2003-07-29
PL176448B1 (pl) 1999-05-31
AU7294894A (en) 1995-03-30
CN1055698C (zh) 2000-08-23
BR9403542A (pt) 1995-06-20
NO943402L (no) 1995-03-15
IL110933A0 (en) 1994-11-28
NO310240B1 (no) 2001-06-11
AU674773B2 (en) 1997-01-09
KR950008534A (ko) 1995-04-19
EP0643073A1 (en) 1995-03-15
EP0643073B1 (en) 1997-11-26
UA32556C2 (uk) 2001-02-15
JPH07149791A (ja) 1995-06-13
RU94034734A (ru) 1996-07-20
DK0643073T3 (da) 1997-12-29
ATE160574T1 (de) 1997-12-15
PL305009A1 (en) 1995-03-20
FI944231L (fi) 1995-03-15
CO4290364A1 (es) 1996-04-17
YU54194A (sh) 1997-01-08
HU9402626D0 (en) 1994-11-28
PH31655A (en) 1999-01-12

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