ES2110738T3 - Inhibidores de farnesil:proteina transferasa como agentes anticancerosos. - Google Patents

Inhibidores de farnesil:proteina transferasa como agentes anticancerosos.

Info

Publication number
ES2110738T3
ES2110738T3 ES94909497T ES94909497T ES2110738T3 ES 2110738 T3 ES2110738 T3 ES 2110738T3 ES 94909497 T ES94909497 T ES 94909497T ES 94909497 T ES94909497 T ES 94909497T ES 2110738 T3 ES2110738 T3 ES 2110738T3
Authority
ES
Spain
Prior art keywords
farnesil
inhibitors
cancer agents
protein transferase
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94909497T
Other languages
English (en)
Inventor
David M Stemerick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2110738T3 publication Critical patent/ES2110738T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3821—Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3826—Acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C07F9/4012—Esters of acyclic acids which can have further substituents on alkyl substituted by B, Si, P or a metal

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A CIERTOS INHIBIDORES DE TRANSFERASA FARNESIL:PROTEINA QUE SON UTILES COMO AGENTES ANTINEOPLASTICOS.
ES94909497T 1993-02-23 1994-01-24 Inhibidores de farnesil:proteina transferasa como agentes anticancerosos. Expired - Lifetime ES2110738T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2141193A 1993-02-23 1993-02-23

Publications (1)

Publication Number Publication Date
ES2110738T3 true ES2110738T3 (es) 1998-02-16

Family

ID=21804071

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94909497T Expired - Lifetime ES2110738T3 (es) 1993-02-23 1994-01-24 Inhibidores de farnesil:proteina transferasa como agentes anticancerosos.

Country Status (19)

Country Link
US (1) US5463181A (es)
EP (1) EP0686159B1 (es)
JP (1) JPH08509470A (es)
KR (1) KR100305128B1 (es)
CN (1) CN1045207C (es)
AT (1) ATE159023T1 (es)
AU (1) AU684071B2 (es)
CA (1) CA2154871C (es)
DE (1) DE69406110T2 (es)
DK (1) DK0686159T3 (es)
ES (1) ES2110738T3 (es)
FI (1) FI111369B (es)
GR (1) GR3025499T3 (es)
HU (1) HUT72647A (es)
IL (1) IL108694A0 (es)
NO (1) NO306618B1 (es)
NZ (1) NZ262585A (es)
TW (1) TW265345B (es)
ZA (1) ZA941099B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
FR2833266B1 (fr) * 2001-12-11 2004-10-22 Mayoly Spindler Lab Nouveaux derives phosphonates, leur procede de preparation, leur utilisation comme modulateurs de l'activite des lymphocytes tgamma9 delta2
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
EP2398500B1 (en) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57142993A (en) * 1981-02-28 1982-09-03 Sagami Chem Res Center 2-hydroxyphosphonic diester
DE3313070A1 (de) * 1983-04-12 1984-10-18 Bayer Ag, 5090 Leverkusen Chlorierte phosphorylmethylcarbonyl-derivate, verfahren zu ihrer herstellung und ihre verwendung in pflanzenschutmitteln
DE3425701A1 (de) * 1984-07-12 1986-01-16 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von chlorierten phosphorylmethylcarbonyl-derivaten und neue zwischenprodukte zu ihrer herstellung
US4924024A (en) * 1988-01-11 1990-05-08 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors, new intermediates and method
US5177239A (en) * 1989-07-18 1993-01-05 E. R. Squibb & Sons, Inc. Method for preparing a phosphonic acid ester
US5298655A (en) * 1991-09-27 1994-03-29 Merck & Co., Inc. Farnesyl pyrophosphate analogs

Also Published As

Publication number Publication date
AU6232494A (en) 1994-09-14
ATE159023T1 (de) 1997-10-15
GR3025499T3 (en) 1998-02-27
AU684071B2 (en) 1997-12-04
FI953934L (fi) 1995-08-22
DK0686159T3 (da) 1998-01-26
CA2154871A1 (en) 1994-09-01
TW265345B (es) 1995-12-11
NO953292D0 (no) 1995-08-22
HUT72647A (en) 1996-05-28
JPH08509470A (ja) 1996-10-08
CN1045207C (zh) 1999-09-22
EP0686159B1 (en) 1997-10-08
EP0686159A1 (en) 1995-12-13
NO306618B1 (no) 1999-11-29
NO953292L (no) 1995-08-22
NZ262585A (en) 1997-12-19
KR100305128B1 (ko) 2001-11-22
FI953934A0 (fi) 1995-08-22
CN1118166A (zh) 1996-03-06
FI111369B (fi) 2003-07-15
DE69406110T2 (de) 1998-05-14
DE69406110D1 (de) 1997-11-13
HU9502455D0 (en) 1995-10-30
US5463181A (en) 1995-10-31
CA2154871C (en) 1998-04-07
IL108694A0 (en) 1994-05-30
ZA941099B (en) 1994-08-30

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