ES2111493A1 - Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes. - Google Patents
Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes.Info
- Publication number
- ES2111493A1 ES2111493A1 ES09600304A ES9600304A ES2111493A1 ES 2111493 A1 ES2111493 A1 ES 2111493A1 ES 09600304 A ES09600304 A ES 09600304A ES 9600304 A ES9600304 A ES 9600304A ES 2111493 A1 ES2111493 A1 ES 2111493A1
- Authority
- ES
- Spain
- Prior art keywords
- alkoxy
- amino
- alkyl
- group
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 title abstract 2
- 229920002554 vinyl polymer Polymers 0.000 title abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 5
- -1 nitro, cyano, amino Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 abstract 1
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003310 benzodiazepinyl group Chemical group N1N=C(C=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DERIVADOS DE 1-[2-(VINILO SUBSTITUIDO)]-5H-2,3-BENZODIAZEPINA, PROCEDIMIENTO DE PREPARACION DE LOS MISMOS, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y UTILIZACIONES CORRESPONDIENTES. LOS COMPUESTOS DE ACUERDO CON LA INVENCION CORRESPONDEN A LA FORMULA GENERAL (I), DONDE A Y B JUNTOS FORMAN UN GRUPO =C=N- O =CH-NH-; R1 REPRESENTA FENILO QUE OPCIONALMENTE LLEVA 2 O 3 GRUPOS HIDROXI O DE 1 A 3 SUBSTITUYENTES IDENTICOS O DIFERENTES SELECCIONADOS ENTRE EL GRUPO CONSISTENTE EN HALOGENO, TRIFLUOROMETILO, NITRO, CIANO, AMINO, ALQUILO (C1-3)AMINO, DI(ALQUILO C1-3)AMINO, (ALCANOILO C1-4)AMINO, ALQUILO C1-4, ALCOXI C1-4, CARBOXI, (ALCOXI C1-4)CARBONILO, (ALCOXI C1-4)CARBONILOXI Y METILENDIOXI; NAFTILO QUE OPCIONALMENTE LLEVA UN SUBSTITUYENTE SELECCIONADO ENTRE EL GRUPO CONSISTENTE EN HIDROXI, ALCOXI C1-4, Y ACILOXI C1-4; FURILO, TIENILO O INDOLILO; R2 REPRESENTA HIDROGENO O ALQUILO C1-4; Y R3 Y R4 SON, INDEPENDIENTEMENTE ENTRE SI, ALCOXI C1-4 UNIDO A LAS POSICIONES 7 Y 8 DEL ANILLO DE BENZODIAZEPINA, O R3 Y R4 JUNTOS FORMAN UN GRUPO 7,8- U 8,9-METILENDIOXI, Y POSEEN ACTIVIDADES VALIOSAS SOBRE EL SISTEMA NERVIOSO CENTRAL.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9600304A ES2111493B1 (es) | 1996-02-08 | 1996-02-08 | Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9600304A ES2111493B1 (es) | 1996-02-08 | 1996-02-08 | Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2111493A1 true ES2111493A1 (es) | 1998-03-01 |
| ES2111493B1 ES2111493B1 (es) | 1999-08-01 |
Family
ID=8293740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9600304A Expired - Fee Related ES2111493B1 (es) | 1996-02-08 | 1996-02-08 | Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2111493B1 (es) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2081426A1 (en) * | 1970-01-12 | 1971-12-03 | Smb Laboratoires | Spasmolytic dihydrobenz-1,4-oxazepine deriv |
| FR2439189A1 (fr) * | 1978-10-19 | 1980-05-16 | Egyt Gyogyszervegyeszeti Gyar | Nouveaux derives de la 5h-2,3-benzodiazepine et procede pour la preparation de ces derives et compositions pharmaceutiques les contenant |
| FR2501686A1 (fr) * | 1981-03-12 | 1982-09-17 | Egyt Gyogyszervegyeszeti Gyar | Nouveaux derives de 3,4-dihydro-5h-2,3-benzodiazepine, procede pour les preparer et medicaments les contenant |
| ES2005582A6 (es) * | 1986-05-21 | 1989-03-16 | Egyt Gyogyszervegyeszeti Gyar | Procedimiento de obtencion de nuevos derivados de la 1-(hidroxiestiril)-5h-2,3-benzodiazepina. |
-
1996
- 1996-02-08 ES ES9600304A patent/ES2111493B1/es not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2081426A1 (en) * | 1970-01-12 | 1971-12-03 | Smb Laboratoires | Spasmolytic dihydrobenz-1,4-oxazepine deriv |
| FR2439189A1 (fr) * | 1978-10-19 | 1980-05-16 | Egyt Gyogyszervegyeszeti Gyar | Nouveaux derives de la 5h-2,3-benzodiazepine et procede pour la preparation de ces derives et compositions pharmaceutiques les contenant |
| FR2501686A1 (fr) * | 1981-03-12 | 1982-09-17 | Egyt Gyogyszervegyeszeti Gyar | Nouveaux derives de 3,4-dihydro-5h-2,3-benzodiazepine, procede pour les preparer et medicaments les contenant |
| ES2005582A6 (es) * | 1986-05-21 | 1989-03-16 | Egyt Gyogyszervegyeszeti Gyar | Procedimiento de obtencion de nuevos derivados de la 1-(hidroxiestiril)-5h-2,3-benzodiazepina. |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2111493B1 (es) | 1999-08-01 |
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| ES2111493B1 (es) | Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19980301 Kind code of ref document: A1 Effective date: 19980301 |
|
| FD2A | Announcement of lapse in spain |
Effective date: 20110809 |