ES2111526T3 - Arilsulfatasa. - Google Patents

Arilsulfatasa.

Info

Publication number
ES2111526T3
ES2111526T3 ES90120104T ES90120104T ES2111526T3 ES 2111526 T3 ES2111526 T3 ES 2111526T3 ES 90120104 T ES90120104 T ES 90120104T ES 90120104 T ES90120104 T ES 90120104T ES 2111526 T3 ES2111526 T3 ES 2111526T3
Authority
ES
Spain
Prior art keywords
arylsulfatase
prodrogue
hydropylophylopylope
ethypopylopylope
ethypetylopylophylopylope
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90120104T
Other languages
English (en)
Inventor
Yosuke Sawada
Tomokazu Ueki
Satoshi Yamamoto
Koji Tomita
Yasuo Fukagawa
Toshikazu Oki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2111526T3 publication Critical patent/ES2111526T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nanotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Valve Device For Special Equipments (AREA)
  • Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)

Abstract

LA PRESENTE INVENCION ES RELATIVA A UNA ARILOSULFATASA DE ORIGEN MICROBIANO. EL ENZIMA PUEDE SER ENLAZADO A UN ANTICUERPO CONTRA UN ANTIGENO ASOCIADO A UN TUMOR Y EL CONJUGADO RESULTANTE USADO EN UNION DE UNA PRODROGA SULFATADA DE DERIVADO DE 4''-DIMETILEPIPODOFILOTOXINA GLUCOSIDA, PARTICULARMENTE ETOPOSIDO EN QUIMIOTERAPIA DEL CANCER.
ES90120104T 1989-10-20 1990-10-19 Arilsulfatasa. Expired - Lifetime ES2111526T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42437689A 1989-10-20 1989-10-20

Publications (1)

Publication Number Publication Date
ES2111526T3 true ES2111526T3 (es) 1998-03-16

Family

ID=23682406

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90120104T Expired - Lifetime ES2111526T3 (es) 1989-10-20 1990-10-19 Arilsulfatasa.

Country Status (14)

Country Link
EP (1) EP0423818B1 (es)
JP (1) JP3097035B2 (es)
KR (1) KR0144351B1 (es)
AT (1) ATE162217T1 (es)
AU (1) AU638283B2 (es)
CA (1) CA2027977C (es)
DE (1) DE69031932T2 (es)
DK (1) DK0423818T3 (es)
ES (1) ES2111526T3 (es)
FI (1) FI94362C (es)
GR (1) GR3026042T3 (es)
IE (1) IE903767A1 (es)
PT (1) PT95625B (es)
ZA (1) ZA908408B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0649330U (ja) * 1992-12-16 1994-07-05 オート化学工業株式会社 流動性物質の貯蔵用容器
GB9323429D0 (en) * 1993-11-12 1994-01-05 Wellcome Found Therapy
GB9422777D0 (en) * 1994-11-11 1995-01-04 Imperial College Assay
WO1997021818A1 (en) * 1995-12-14 1997-06-19 Kyoto Daiichi Kagaku Co., Ltd. Novel fructosyl amino acid oxidase originating in fungi of the genus penicillium
DE10155764A1 (de) * 2001-11-14 2003-05-28 Degussa Neue Sulfatasen und ihre Verwendung
JP4606712B2 (ja) 2003-01-08 2011-01-05 マサチューセッツ インスティテュート オブ テクノロジー ２−ｏスルファターゼ組成物および関連の方法
WO2008085912A1 (en) 2007-01-05 2008-07-17 Massachusetts Institute Of Technology Compositions of and methods of using sulfatases from flavobacterium heparinum

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1262565A (fr) * 1956-05-16 1961-06-05 Procédé de fabrication de produits agricoles par fermentation et produits conformes à ceux ainsi obtenus
NZ225599A (en) * 1987-08-04 1991-09-25 Bristol Myers Co Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells

Also Published As

Publication number Publication date
AU638283B2 (en) 1993-06-24
KR910008131A (ko) 1991-05-30
FI905107A0 (fi) 1990-10-17
EP0423818A1 (en) 1991-04-24
JPH03155781A (ja) 1991-07-03
AU6470890A (en) 1991-04-26
ATE162217T1 (de) 1998-01-15
FI94362B (fi) 1995-05-15
GR3026042T3 (en) 1998-04-30
IE903767A1 (en) 1991-04-24
PT95625B (pt) 1997-08-29
DE69031932T2 (de) 1998-08-27
FI94362C (fi) 1995-08-25
DE69031932D1 (de) 1998-02-19
EP0423818B1 (en) 1998-01-14
PT95625A (pt) 1991-09-13
CA2027977A1 (en) 1992-04-19
CA2027977C (en) 2000-01-18
JP3097035B2 (ja) 2000-10-10
KR0144351B1 (ko) 1998-07-01
DK0423818T3 (da) 1998-09-07
ZA908408B (en) 1992-06-24

Similar Documents

Publication Publication Date Title
DE3687779D1 (de) Trichotecenkonjugate.
TR199701547T1 (xx) Polisakarit antijen protein e�leni�i i�eren a��.
FR12C0059I1 (es)
ATE104153T1 (de) Rekombinantes pseudomonastoxin : konstruktion eines wirksamen immunotoxins mit wenigen nebenwirkungen.
IT1187753B (it) Coniugati glicoproteici ad attivita' immunogenica trivalente
NZ334828A (en) Contains no O-acetyl groups detectable by NMR and binds to antibodies to S.aureus further conjugated with Pseudomonas aeruginosa exotoxin A as an immunocarrier to detect S.aureus infection
ATE355079T1 (de) Behandlung von prostata-krebs mit anti-erbb2 antikörpern
BRPI0012196B8 (pt) artigo industrializado
ES2170102T3 (es) Aminociclohexilesteres y utilizacion de los mismos.
ES2151603T3 (es) Anticuerpo monoclonal contra cd44v6.
ATE68977T1 (de) Pharmazeutisch aktive konjugate mit spezifitaet fuer die bindung an koerpergewebe.
CA2076347A1 (en) Improved antibody-enzyme direct conjugates and method of making same
ES2057069T3 (es) Conjugado de prostaglandina y polisacarido.
IL95578A0 (en) Vaccine formed from a poly-saccharide and a protein
ES2119738T3 (es) Profarmacos de etoposido de glicosilo, procedimiento para su preparacion y su aplicacion en combinacion con conjugados enzimaticos funcionalizados, especificos de tumores.
TR199903074T2 (xx) Kanser tedavisinde HMG CoA ve farnesil transfer �nleyicileri.
GB1508878A (en) Hepatitis a antigen
BR0013221A (pt) Chá preto de folha
ATE162217T1 (de) Arylsulfatase
NO168989C (no) Fremgangsmaate for aa oeke loeseligheten av f. eks. immunokonjugatpreparater
ES2125442T3 (es) Extraccion de proteina celular de bordetella.
TW223019B (es)
IT1254147B (it) Metodo di rivelazione di marcatori tumorali.
DK136088A (da) Peptid
AU144596S (en) Mens underwear

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 423818

Country of ref document: ES