ES2111659T3 - Comprimidos, granulados y nodulos con alto contenido en sustancias activas para formas de administracion solidas de alta concentracion. - Google Patents

Comprimidos, granulados y nodulos con alto contenido en sustancias activas para formas de administracion solidas de alta concentracion.

Info

Publication number
ES2111659T3
ES2111659T3 ES93102525T ES93102525T ES2111659T3 ES 2111659 T3 ES2111659 T3 ES 2111659T3 ES 93102525 T ES93102525 T ES 93102525T ES 93102525 T ES93102525 T ES 93102525T ES 2111659 T3 ES2111659 T3 ES 2111659T3
Authority
ES
Spain
Prior art keywords
granulates
nodules
tablets
administration
active substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93102525T
Other languages
English (en)
Inventor
Joachim Dr Goede
Jurgen Prof Engel
Helmut Dr Hettche
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Medica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6453779&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2111659(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Asta Medica GmbH filed Critical Asta Medica GmbH
Application granted granted Critical
Publication of ES2111659T3 publication Critical patent/ES2111659T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PRESENTACIONES DE MEDICAMENTOS SOLIDAS, CON UN CONTENIDO EN SUSTANCIA ACTIVA SUPERIOR AL 45 % DE SU PESO, Y PROCEDIMIENTO PARA LA OBTENCION POR MEDIO DE GRANULADOS CON MUCHA AGUA, SECADO Y, DADO EL CASO, LOS PROCEDIMIENTOS HABITUALES DE PARA PRODUCIR PASTILLAS Y/O PELLETS.
ES93102525T 1992-03-11 1993-02-18 Comprimidos, granulados y nodulos con alto contenido en sustancias activas para formas de administracion solidas de alta concentracion. Expired - Lifetime ES2111659T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4207717 1992-03-11

Publications (1)

Publication Number Publication Date
ES2111659T3 true ES2111659T3 (es) 1998-03-16

Family

ID=6453779

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93102525T Expired - Lifetime ES2111659T3 (es) 1992-03-11 1993-02-18 Comprimidos, granulados y nodulos con alto contenido en sustancias activas para formas de administracion solidas de alta concentracion.

Country Status (11)

Country Link
US (2) US5376382A (es)
EP (1) EP0560092B1 (es)
JP (1) JPH0616543A (es)
AT (1) ATE160696T1 (es)
CA (1) CA2091370C (es)
DE (3) DE9321574U1 (es)
DK (1) DK0560092T3 (es)
ES (1) ES2111659T3 (es)
GR (1) GR3025936T3 (es)
HU (1) HU217818B (es)
MX (1) MX9301311A (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2111659T3 (es) * 1992-03-11 1998-03-16 Asta Medica Ag Comprimidos, granulados y nodulos con alto contenido en sustancias activas para formas de administracion solidas de alta concentracion.
DE4319649A1 (de) * 1993-03-18 1994-09-22 Asta Medica Ag Feste Flupirtin enthaltende orale Darreichungsformen mit kontrollierter Wirkstoffabgabe
DE4400269C2 (de) * 1994-01-10 1998-10-01 Asta Medica Ag Tabletten mit Thioctsäure bestimmter Korngröße
DE4433764A1 (de) * 1994-09-22 1996-03-28 Asta Medica Ag Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit
DE4439480C1 (de) * 1994-11-08 1996-06-05 Asta Medica Ag Verwendung von D,L- alpha-Liponsäure und/oder ihren Enantiomeren, und/oder ihren Derivaten als Zusatz bei Erythrozyten-Flüssigkonserven für homologe und autologe Erythrozyten-Konzentrate und als Zusatz bei Erythrozyten-Kryokonserven für homologe und autologe Erythrozytenkonzentrate
DE19510130C1 (de) * 1995-03-21 1996-11-21 Asta Medica Ag Verfahren zur Herstellung rieselfähiger R,S-Thioctsäure, R,S-Thioctsäure sowie deren Verwendung
PL178713B1 (pl) * 1995-03-31 2000-06-30 Centrum Badan Molekularnych I Makromolekularnych Pan Środek farmaceutyczny o działaniu przeciwnowotworowym
US5994348A (en) 1995-06-07 1999-11-30 Sanofi Pharmaceutical compositions containing irbesartan
DE19705555A1 (de) * 1997-02-13 1998-08-20 Ulrich Dr Posanski Pharmazeutische Präparate der Thioctsäure zur oralen Anwendung
US5981499A (en) * 1998-02-20 1999-11-09 Atlantic Biomed Corporation Lesion-directed antibiotics in dry dosage forms for the treatment of shallow ulcers of the oral mucosa
EP0955040A1 (de) 1998-04-27 1999-11-10 ASTA Medica Aktiengesellschaft Arzneiform zur oralen Applikation von Mesna
WO1999059572A1 (en) * 1998-05-15 1999-11-25 Warner-Lambert Company Gamma-aminobutyric acid derivatives containing, solid compositions and process for preparing the same
US6197340B1 (en) * 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
US20050085498A1 (en) * 1998-05-28 2005-04-21 Byrd Edward A. Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate
US20040259895A1 (en) * 1998-05-28 2004-12-23 Medical Research Institute Oral formulation of lipid soluble thiamine and lipoic acid
US6905707B2 (en) * 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
US6191162B1 (en) 1998-05-28 2001-02-20 Medical Research Institute Method of reducing serum glucose levels
FR2790949B1 (fr) * 1999-03-16 2001-06-22 Talc De Luzenac Procede de fabrication de comprimes pharmaceutiques par compression
US6248718B1 (en) 1999-08-18 2001-06-19 Atlantic Biomed Corporation Lesion-directed dry dosage forms of antibacterial agents for the treatment of acute mucosal infections of the oral cavity
AU7911000A (en) * 1999-10-01 2001-05-10 Skw Trostberg Aktiengesellschaft Retard form containing alpha-lipoic acid (derivatives)
DE10045904B4 (de) * 1999-10-01 2007-07-12 Degussa Gmbh alpha-Liponsäure(-Derivate) enthaltende Retardform
US6821995B1 (en) 1999-12-01 2004-11-23 Duke University Method of treating batten disease
WO2003079819A1 (en) * 2002-03-27 2003-10-02 Anglo French Drugs And Industries Ltd. Dietary supplement composition and a process of manufacturing said composition
US9107804B2 (en) 2002-12-10 2015-08-18 Nortec Development Associates, Inc. Method of preparing biologically active formulations
DE10327674A1 (de) * 2003-06-20 2005-01-05 Awd.Pharma Gmbh & Co. Kg Injizierbare Darreichungsform von Flupirtin
JP2007520495A (ja) 2004-02-06 2007-07-26 ボロディー トーマス ユリウス 下痢型過敏性腸症候群におけるアミノサリチル酸の使用法
US20080306029A1 (en) * 2004-05-28 2008-12-11 Salix Pharmaceuticals, Inc. Prevention, Treatment, and Amelioration of Radiation Induced Enteritis
EP1688141A1 (en) * 2005-01-31 2006-08-09 elbion AG The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome
US8921344B2 (en) * 2006-11-03 2014-12-30 Salix Pharmaceuticals, Inc. Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives
US7452872B2 (en) 2005-08-24 2008-11-18 Salix Pharmaceuticals, Inc. Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives
CA2816276A1 (en) * 2005-08-24 2007-03-01 Salix Pharmaceuticals, Inc. Balsalazide formulations and manufacture and use thereof
US20080279930A1 (en) * 2007-05-07 2008-11-13 Bernd Terhaag Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof
ITMI20072427A1 (it) * 2007-12-24 2009-06-25 I P S Internat Products & Ser Matrce polimerica polivalente a immediata disgregazione per prodotti solidi per uso orale a rilascio modificato e metodo per la sua preparazione
BRPI0916476A2 (pt) * 2008-12-01 2016-02-16 Invasc Therapeutics Inc composição, método de tratamento para um distúrbio relacionado ao sistema renina-angiotensina-aldosterona, método para reduzir a resistência à insulina, método para tratar um distúrbio relacionado à síndrome metabólica
DE102010030053A1 (de) 2010-06-14 2011-12-15 Awd.Pharma Gmbh & Co.Kg Injizierbare Darreichungsform von Flupirtin
CN104083335B (zh) * 2013-07-31 2015-11-11 成都苑东药业有限公司 一种马来酸氟吡汀胶囊组合物及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213141B (it) * 1984-02-17 1989-12-14 Dobrivoje Tomic Composizioni farmaceutiche per il trattamento del diabete e di malattie e disfunzioni epatiche.
DE3665538D1 (en) * 1985-01-23 1989-10-19 Asta Pharma Ag Synergistic combination of flupirtin and non-steroidal anti-phlogistics
IT1185551B (it) * 1985-04-15 1987-11-12 Schering Spa Composizioni farmaceutiche a base di acido mercaptoetansolfonico ad attivita' terapeutica,derivati salini organici dell'acido mercaptoetansolfonico utili per tali composizioni e relativo procedimento di preparazione
DE58902094D1 (de) * 1988-01-28 1992-10-01 Koeltringer Peter Kombinationspraeparat zur behandlung von nervenzell-und nervenfasererkrankungen und verletzungen.
ES2060737T3 (es) * 1988-02-25 1994-12-01 Yamanouchi Europ Bv Procedimiento de preparacion de un granulado farmaceutico.
DE3915184A1 (de) * 1988-05-16 1989-11-30 Asta Pharma Ag Substituierte 3-(n-heterocyclyl)-2,6-diaminopyridine und -n-oxide, ihre herstellung und verwendung als arzneimittel
FR2653997B1 (fr) * 1989-11-09 1995-01-20 Asta Pharma Ag Medicaments contenant comme sunstances actives des acides carboxyliques soufres, leur preparation et leur utilisation pour lutter contre les retrovirus.
PT95826B (pt) * 1989-11-09 1997-11-28 Asta Medica Ag Processo para a preparacao de composicoes farmaceuticas contendo como ingrediente activo acido r-alfa-liponico ou acido s-alfa-liponico
IN172468B (es) * 1990-07-14 1993-08-14 Asta Medica Ag
ES2063412T3 (es) * 1990-07-16 1995-01-01 Asta Medica Ag Tableta y granulado que contienen como principio activo mesna.
ES2111659T3 (es) * 1992-03-11 1998-03-16 Asta Medica Ag Comprimidos, granulados y nodulos con alto contenido en sustancias activas para formas de administracion solidas de alta concentracion.

Also Published As

Publication number Publication date
HUT65527A (en) 1994-06-28
EP0560092B1 (de) 1997-12-03
MX9301311A (es) 1993-09-01
EP0560092A1 (de) 1993-09-15
HU9300700D0 (en) 1993-05-28
GR3025936T3 (en) 1998-04-30
DE4305079A1 (en) 1993-09-23
CA2091370A1 (en) 1993-09-12
HU217818B (hu) 2000-04-28
ATE160696T1 (de) 1997-12-15
US5376382A (en) 1994-12-27
DK0560092T3 (da) 1998-08-10
JPH0616543A (ja) 1994-01-25
CA2091370C (en) 2005-08-02
DE9321574U1 (de) 2000-06-29
DE59307753D1 (de) 1998-01-15
US5503845A (en) 1996-04-02

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