ES2112833T3 - Aislamiento de celulas fetales a partir de sangre materna para permitir el diagnostico prenatal. - Google Patents

Aislamiento de celulas fetales a partir de sangre materna para permitir el diagnostico prenatal.

Info

Publication number
ES2112833T3
ES2112833T3 ES90900018T ES90900018T ES2112833T3 ES 2112833 T3 ES2112833 T3 ES 2112833T3 ES 90900018 T ES90900018 T ES 90900018T ES 90900018 T ES90900018 T ES 90900018T ES 2112833 T3 ES2112833 T3 ES 2112833T3
Authority
ES
Spain
Prior art keywords
pct
cells
isolation
maternal blood
fetal cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90900018T
Other languages
English (en)
Inventor
Utz Walter Mueller
Catherine Stella Hawes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flinders Technologies Pty Ltd
Original Assignee
Flinders Technologies Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flinders Technologies Pty Ltd filed Critical Flinders Technologies Pty Ltd
Application granted granted Critical
Publication of ES2112833T3 publication Critical patent/ES2112833T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

ESTA INVENCION SE REFIERE A UN METODO PARA AISLAR LAS CELULAS TROFOBLASTOS (PLACENTA) DE LA SANGRE DE UN MAMIFERO PREÑADO DE FORMA QUE PROPORCIONE EL MATERIAL DE COMIENZO ESENCIAL, LLAMADO CELULAS DERIVADO DEL FETO, PARA PERMITIR LA INFORMACION GENETICA Y/O BIOQUIMICA ACERCA DEL FETO QUE SE VA A OBTENER. EN PARTICULAR, LA INVENCION SE REFIERE A LA UTILIZACION DE ANTICUERPOS MONOCLONICOS ESPECIFICOS PARA LOS MARCADORES DE LAS PROTEINAS DE LAS MEMBRANAS EN LOS TROFOBLASTOS DE LOS MAMIFEROS PARA AISLAR LAS CELULAS TROFOBLASTOS DE LA SANGRE MATERNA. ESTAS CELULAS PUEDEN UTILIZARSE ENTONCES PARA OBTENER INFORMACION GENETICA Y/O BIOQUIMICA A PRINCIPIOS DEL EMBARAZO. LA INVENCION ACTUAL ES PARTICULARMENTE IMPORTANTE PARA DETECTAR ANORMALIDADES DE LOS FETOS HUMANOS .
ES90900018T 1988-12-06 1989-11-29 Aislamiento de celulas fetales a partir de sangre materna para permitir el diagnostico prenatal. Expired - Lifetime ES2112833T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPJ182488 1988-12-06

Publications (1)

Publication Number Publication Date
ES2112833T3 true ES2112833T3 (es) 1998-04-16

Family

ID=3773565

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90900018T Expired - Lifetime ES2112833T3 (es) 1988-12-06 1989-11-29 Aislamiento de celulas fetales a partir de sangre materna para permitir el diagnostico prenatal.

Country Status (11)

Country Link
US (1) US5503981A (es)
EP (1) EP0447424B1 (es)
JP (1) JP2935741B2 (es)
CN (1) CN1021257C (es)
AT (1) ATE161960T1 (es)
CA (1) CA2004592A1 (es)
DE (1) DE68928535T2 (es)
DK (1) DK107391A (es)
ES (1) ES2112833T3 (es)
NZ (1) NZ231621A (es)
WO (1) WO1990006509A1 (es)

Families Citing this family (54)

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US6872817B1 (en) 1986-01-16 2005-03-29 The Regents Of The Univ. Of California Method of staining target interphase chromosomal DNA
US5447841A (en) 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US6344315B1 (en) 1986-01-16 2002-02-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
US6475720B1 (en) 1986-01-16 2002-11-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
US5756696A (en) 1986-01-16 1998-05-26 Regents Of The University Of California Compositions for chromosome-specific staining
US7115709B1 (en) * 1986-01-16 2006-10-03 The Regents Of The University Of California Methods of staining target chromosomal DNA employing high complexity nucleic acid probes
ATE163971T1 (de) * 1989-08-03 1998-03-15 Univ California Verfahren zur isolierung von fetalen zytotrophoblastzellen
AU658132B2 (en) * 1989-11-13 1995-04-06 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
US5641628A (en) * 1989-11-13 1997-06-24 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
US5153117A (en) * 1990-03-27 1992-10-06 Genetype A.G. Fetal cell recovery method
FR2682481A1 (fr) * 1991-10-11 1993-04-16 Saint Cy Scp Procede d'obtention de cellules trophoblastiques d'un fóoetus.
JPH07500499A (ja) * 1991-10-23 1995-01-19 セルプロ　インコーポレイテッド 母親の血液由来の胎児始原細胞を濃厚化する方法
FR2685777A1 (fr) * 1991-12-31 1993-07-02 Bertin & Cie Procede de depistage prenatal d'anomalies fóoetales et procede de depistage prenatal du sexe.
DE4222573C1 (es) * 1992-05-16 1993-08-12 Dorothee Dr. 4400 Muenster De Ahlert
US5457024A (en) * 1993-01-22 1995-10-10 Aprogenex, Inc. Isolation of fetal erythrocytes
US5662813A (en) 1994-10-21 1997-09-02 Bioseparations, Inc. Method for separation of nucleated fetal erythrocytes from maternal blood samples
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5801145A (en) * 1996-02-09 1998-09-01 Ontario Cancer Institute Method for selectively purging CD77+ cells from bone marrow
AUPO931997A0 (en) * 1997-09-22 1997-10-09 Flinders Technologies Pty Ltd Enrichment and identification of trophoblast cells in maternal peripheral blood
US6221596B1 (en) 1999-05-17 2001-04-24 Motobit Ltd. System and method for identifying and isolating rare cells from a mixed population of cells
AU5967100A (en) * 1999-07-21 2001-02-13 Britta Christensen A novel method for the improved isolation of a target cell population
DE19964044C2 (de) * 1999-12-30 2001-11-22 Frank Hans Georg Verfahren zur Identifizierung von Substanzen, die Säugetier-Epitope nachahmen
SK9262002A3 (en) * 1999-12-30 2003-02-04 Hans-Georg Frank Method for identifying substances which mimic mammal epitopes
US20020045196A1 (en) * 2000-05-12 2002-04-18 Walt Mahoney Methods of isolating trophoblast cells from maternal blood
US20050100951A1 (en) * 2000-10-26 2005-05-12 Biocept, Inc. 3D format biochips and method of use
RU2202790C2 (ru) * 2001-03-26 2003-04-20 Северный государственный медицинский университет Способ диагностики внутриутробного инфицирования плода
FR2824144B1 (fr) 2001-04-30 2004-09-17 Metagenex S A R L Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel
EP1462800A4 (en) * 2001-12-11 2007-01-17 Netech Inc SYSTEM FOR SEPARATING BLOOD CELLS
CA2492631C (en) * 2002-05-31 2013-03-12 Genetic Technologies Limited Maternal antibodies as fetal cell markers to identify and enrich fetal cells from maternal blood
RU2237897C2 (ru) * 2002-07-17 2004-10-10 ГУ "Ивановский научно-исследовательский институт материнства и детства им. В.Н.Городкова" Способ прогнозирования инфекционных заболеваний новорожденных
AU2003277153A1 (en) 2002-09-27 2004-04-19 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
EP1599608A4 (en) * 2003-03-05 2007-07-18 Genetic Technologies Ltd Identification of fetal DNA and fetal cell marker in maternal plasma or serum
US20050181429A1 (en) * 2003-04-03 2005-08-18 Monaliza Medical Ltd. Non-invasive prenatal genetic diagnosis using transcervical cells
US20040197832A1 (en) * 2003-04-03 2004-10-07 Mor Research Applications Ltd. Non-invasive prenatal genetic diagnosis using transcervical cells
JP2007508017A (ja) * 2003-10-08 2007-04-05 ザ トラスティーズ オブ ボストン ユニバーシティ 染色体異常の出生前診断のための方法
US7439062B2 (en) * 2004-12-23 2008-10-21 Biocept, Inc. Beads for capturing target cells from bodily fluid
FR2880897B1 (fr) 2005-01-18 2010-12-17 Inst Nat Sante Rech Med Methode de detection, non invasive, prenatale, in vitro de l'etat sain normal, de l'etat de porteur sain ou de l'etat de porteur malade de la mucoviscidose
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
EP2029779A4 (en) 2006-06-14 2010-01-20 Living Microsystems Inc HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US8338113B2 (en) 2007-05-01 2012-12-25 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods for detecting fetal cells in the maternal blood
EP2250497B1 (en) * 2008-02-18 2014-09-10 Genetic Technologies Limited Cell processing and/or enrichment methods
ES2620012T3 (es) 2008-09-20 2017-06-27 The Board Of Trustees Of The Leland Stanford Junior University Diagnóstico no invasivo de la aneuploidia fetal por secuenciación
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AU2010264072A1 (en) * 2009-06-24 2012-02-16 Health Corporation - Rambam Methods and kits for isolating placental derived microparticles and use of same for diagnosis of fetal disorders
CN101935700A (zh) * 2010-07-15 2011-01-05 浙江大学 鉴定绵羊早期胚胎性别的牙釉蛋白基因引物及其应用
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CN103230416A (zh) * 2013-04-16 2013-08-07 中国人民解放军第三军医大学第三附属医院 一种小鼠合体滋养细胞微绒毛膜的制备方法及其应用
WO2016057993A1 (en) * 2014-10-10 2016-04-14 Wayne State University Methods and compositions relating to assays of fetal extravillous trophoblast cells
RU2695356C1 (ru) * 2018-11-14 2019-07-23 Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации (ФГБОУ ДПО РМАНПО Минздрава России) Способ прогнозирования состояния плода при преждевременном разрыве плодных оболочек с 24 до 33 недель беременности
CN112980779B (zh) * 2021-05-20 2021-08-24 广州凯普医药科技有限公司 一种从孕妇宫颈脱落细胞中分离胎盘滋养层细胞的方法

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Also Published As

Publication number Publication date
CN1021257C (zh) 1993-06-16
JPH04502060A (ja) 1992-04-09
EP0447424A4 (en) 1992-06-24
JP2935741B2 (ja) 1999-08-16
WO1990006509A1 (en) 1990-06-14
US5503981A (en) 1996-04-02
DK107391A (da) 1991-07-31
ATE161960T1 (de) 1998-01-15
CN1043788A (zh) 1990-07-11
CA2004592A1 (en) 1990-06-06
DE68928535D1 (de) 1998-02-12
EP0447424A1 (en) 1991-09-25
NZ231621A (en) 1992-11-25
DE68928535T2 (de) 1998-04-16
EP0447424B1 (en) 1998-01-07
DK107391D0 (da) 1991-06-06

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