ES2112869T3 - Anticuerpos monoclonales contra celulas de islotes del pancreas humano. - Google Patents

Anticuerpos monoclonales contra celulas de islotes del pancreas humano.

Info

Publication number
ES2112869T3
ES2112869T3 ES92102187T ES92102187T ES2112869T3 ES 2112869 T3 ES2112869 T3 ES 2112869T3 ES 92102187 T ES92102187 T ES 92102187T ES 92102187 T ES92102187 T ES 92102187T ES 2112869 T3 ES2112869 T3 ES 2112869T3
Authority
ES
Spain
Prior art keywords
human
cells
immortalised
antibodies
pancreatic islet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92102187T
Other languages
English (en)
Inventor
Josef Dr Endl
Michael Dr Brandt
Herbert Dr Jungfer
Winfried Dr Albert
Rosemarie Dr Kientsch-Engel
Werner Scherbaum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2112869T3 publication Critical patent/ES2112869T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA INVENCION TRATA DE ANTICUERPOS MONOCLONALES Y HUMANOS DE UN TIPO DE ISO-IGG CONTRA LAS CELULAS INSULARES DEL PANCREAS HUMANO, LAS CUALES SE OBTIENEN MEDIANTE LA INMORTALIZACION DE LINFOCITOS HUMANOS DE PREDIABETICOS O DIABETICOS. LA INVENCION TAMBIEN TRATA DEL TRATAMIENTO DEL PASO DE LAS CELULAS INMORTALES CON UN CONJUGADO DE ANTICUERPOS CONTRA FCY HUMANO Y DE UNA MARCACION QUE INCLUYE TAMBIEN EL TRATAMIENTO DE INMUNOGLOBINA HUMANA, INCUBADA CON CELULAS INSULARES DEL PANCREAS HUMANO E INMOVILIZADAS. LA IDENTIFICACION DE UNA CULTURA CELULAR HUMANA E INMORTAL QUE PRODUCE UN ANTICUERPO CONTRA LA CELULA INSULAR DEL PANCREAS SOBRE LA DETERMINACION DE LA MARCACION UNIDA A CELULAS INSULARES E INMOVILES. LA INVENCION TAMBIEN TRATA DEL AISLAMIENTO DE UNA CELULA INMORTALIZADA Y HUMANA QUE PRODUCE ESTOS ANTICUERPOS Y LA AMPLIFICACION DE ESTAS CELULAS INMORTALES Y EL AISLAMIENTO DE ANTICUERPOS MONOCLONALES PRODUCIDOS POR ESTAS CELULAS. OTRO OBJETO DE LA INVENCION ES UN METODO PARA LA OBTENCION DE ANTIGENOS DE CELULAS INSULARES EN EL CUAL SE FORMAN ESTOS ANTICUERPOS, ASI COMO UN METODO PARA LA DETERMINACION DE LOS ANTICUERPOS CONTRA LAS CELULAS INSULARES DEL PANCREAS.
ES92102187T 1991-02-14 1992-02-10 Anticuerpos monoclonales contra celulas de islotes del pancreas humano. Expired - Lifetime ES2112869T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4104498 1991-02-14
DE4129849A DE4129849A1 (de) 1991-02-14 1991-09-07 Monoklonale antikoerper gegen humane pankreas-inselzellen

Publications (1)

Publication Number Publication Date
ES2112869T3 true ES2112869T3 (es) 1998-04-16

Family

ID=25901030

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92102187T Expired - Lifetime ES2112869T3 (es) 1991-02-14 1992-02-10 Anticuerpos monoclonales contra celulas de islotes del pancreas humano.

Country Status (6)

Country Link
US (2) US5888813A (es)
EP (1) EP0499176B1 (es)
JP (1) JPH07116239B2 (es)
AT (1) ATE161581T1 (es)
DE (2) DE4129849A1 (es)
ES (1) ES2112869T3 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4129849A1 (de) * 1991-02-14 1992-08-27 Boehringer Mannheim Gmbh Monoklonale antikoerper gegen humane pankreas-inselzellen
DE19839736A1 (de) 1998-09-01 2000-03-02 Roche Diagnostics Gmbh Humane monoklonale Antikörper gegen Inselzellantigen IA-2
US6967019B2 (en) * 1999-04-06 2005-11-22 The Regents Of The University Of California Production of pancreatic islet cells and delivery of insulin
US8193330B2 (en) 1999-04-06 2012-06-05 The Regents Of The University Of California Polynucleotides comprising Neurogenin3 promoter and bHLH encoding domains
US7824864B2 (en) * 2000-05-18 2010-11-02 The United States Of America As Represented By The Secretary Of The Army Detection of human antibodies to squalene in serum
USRE46351E1 (en) 2001-05-10 2017-03-28 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
US6989276B2 (en) 2001-05-10 2006-01-24 Battelle Energy Alliance, Llc Rapid classification of biological components
WO2003016575A1 (en) * 2001-08-17 2003-02-27 Luminex Corporation Method for characterizing autoimmune disorders
US20050069962A1 (en) 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
US8323903B2 (en) * 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
PL1737945T3 (pl) 2004-04-19 2011-07-29 Aventis Pharma Sa Sposób oczyszczania plazmidowego DNA
US20080286881A1 (en) * 2007-05-14 2008-11-20 Apel William A Compositions and methods for combining report antibodies
US8969009B2 (en) * 2009-09-17 2015-03-03 Vicki S. Thompson Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
US9410965B2 (en) * 2009-09-17 2016-08-09 Battelle Energy Alliance, Llc Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
USD709510S1 (en) * 2012-02-29 2014-07-22 Hatch, Inc. Tablet cover
US8852873B2 (en) 2012-04-13 2014-10-07 Diabetomics, Llc Maternal biomarkers for gestational diabetes
IL260532B2 (en) 2016-01-11 2023-12-01 Univ Leland Stanford Junior Chimeric proteins- containing systems and uses thereof in regulating gene expression
MX2018008345A (es) * 2016-01-11 2018-12-06 Univ Leland Stanford Junior Proteínas quiméricas y métodos de inmunoterapia.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536479A (en) * 1983-03-22 1985-08-20 E. I. Du Pont De Nemours And Company Use of anti-idiotype antibodies in immunoassays
US4699880A (en) * 1984-09-25 1987-10-13 Immunomedics, Inc. Method of producing monoclonal anti-idiotype antibody
JPH0695949B2 (ja) * 1987-09-08 1994-11-30 工業技術院長 ヒトＩｇＧ１型モノクローン抗体
US4870007A (en) * 1987-12-18 1989-09-26 Eastman Kodak Company Immobilized biotinylated receptor in test device, kit and method for determining a ligand
DE4129849A1 (de) * 1991-02-14 1992-08-27 Boehringer Mannheim Gmbh Monoklonale antikoerper gegen humane pankreas-inselzellen

Also Published As

Publication number Publication date
US5888813A (en) 1999-03-30
JPH07116239B2 (ja) 1995-12-13
ATE161581T1 (de) 1998-01-15
EP0499176A3 (en) 1993-11-10
EP0499176B1 (de) 1997-12-29
DE59209079D1 (de) 1998-02-05
US6214568B1 (en) 2001-04-10
EP0499176A2 (de) 1992-08-19
JPH05115296A (ja) 1993-05-14
DE4129849A1 (de) 1992-08-27

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