ES2112995T3 - Procedimiento biotecnologico para la preparacion de biotina. - Google Patents

Procedimiento biotecnologico para la preparacion de biotina.

Info

Publication number
ES2112995T3
ES2112995T3 ES93920855T ES93920855T ES2112995T3 ES 2112995 T3 ES2112995 T3 ES 2112995T3 ES 93920855 T ES93920855 T ES 93920855T ES 93920855 T ES93920855 T ES 93920855T ES 2112995 T3 ES2112995 T3 ES 2112995T3
Authority
ES
Spain
Prior art keywords
biotin
preparation
dna fragments
biotechnological procedure
microorganisms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93920855T
Other languages
English (en)
Inventor
Olwen Birch
Johann Brass
Martin Fuhrmann
Nicholas Shaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Application granted granted Critical
Publication of ES2112995T3 publication Critical patent/ES2112995T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • C12P17/186—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system containing a 2-oxo-thieno[3,4-d]imidazol nucleus, e.g. Biotin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A FRAGMENTOS DNA Y PLASMIDAS COMPRENDIENDO LOS GENES DE BIOSINTESIS DE BIOTINA BIOB, BIOF, BIOC, BIOD Y BIOA O SUS VARIANTES GENETICAS EQUIVALENTES FUNCIONALMENTE Y MUTANTES A PARTIR DE ENTEROBACTERIAS, DONDE LOS GENES ESTAN DISPUESTOS EN UNA UNIDAD DE TRANSCRIPCION. LA INVENCION SE REFIERE TAMBIEN A MICROORGANISMOS QUE CONTIENEN ESTOS FRAGMENTOS DNA Y A PLASMIDAS, ASI COMO A UN PROCESO PARA LA ELABORACION DE BIOTINA UTILIZANDO ESTOS MICROORGANISMOS.
ES93920855T 1992-10-02 1993-10-01 Procedimiento biotecnologico para la preparacion de biotina. Expired - Lifetime ES2112995T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH312492 1992-10-02
CH213493 1993-07-15

Publications (1)

Publication Number Publication Date
ES2112995T3 true ES2112995T3 (es) 1998-04-16

Family

ID=25689605

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93920855T Expired - Lifetime ES2112995T3 (es) 1992-10-02 1993-10-01 Procedimiento biotecnologico para la preparacion de biotina.

Country Status (16)

Country Link
US (1) US6083712A (es)
EP (2) EP0667909B1 (es)
JP (2) JP3566287B2 (es)
KR (1) KR100200542B1 (es)
AT (1) ATE163198T1 (es)
AU (1) AU4820293A (es)
CA (1) CA2145400C (es)
CZ (1) CZ285533B6 (es)
DE (1) DE59308149D1 (es)
DK (1) DK0667909T3 (es)
ES (1) ES2112995T3 (es)
FI (1) FI117515B (es)
HU (1) HU219827B (es)
PL (2) PL177635B1 (es)
SK (1) SK279669B6 (es)
WO (1) WO1994008023A2 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859335A (en) * 1994-12-08 1999-01-12 Novartis Finance Corporation Enhanced biotin biosynthesis in plant tissue
US5869719A (en) * 1995-03-08 1999-02-09 Novartis Finance Corporation Transgenic plants having increased biotin content
WO1997016560A1 (en) * 1995-11-02 1997-05-09 Takeda Chemical Industries, Ltd. Microorganism resistant to threonine analogue and production of biotin
ES2201219T3 (es) 1996-05-06 2004-03-16 F. Hoffmann-La Roche Ag Produccion fermentativa de biotina.
EP0853127B1 (en) 1996-09-27 2004-11-03 DSM IP Assets B.V. Biotin biosynthetic genes II
US6737256B2 (en) 1997-07-14 2004-05-18 Roche Vitamins Inc. Overcoming DAPA aminotransferase bottlenecks in biotin vitamers biosynthesis
DE19731274A1 (de) 1997-07-22 1999-01-28 Basf Ag Verfahren zur Herstellung von Biotin
EP1025217B1 (en) * 1997-10-24 2006-10-04 Invitrogen Corporation Recombinational cloning using nucleic acids having recombination sites
EP1212429B1 (en) * 1999-09-08 2006-06-28 Xenogen Corporation Luciferase expression cassettes and methods of use
US6660907B2 (en) 2000-07-10 2003-12-09 Pioneer Hi-Bred International, Inc. Genes encoding SCIP-1 orthologs and methods of use
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
WO2002090596A1 (en) * 2001-05-07 2002-11-14 Paradigm Genetics, Inc. Methods for the identification of inhibitors of biotim synthase expression or activity in plants
WO2005054438A2 (en) 2003-12-01 2005-06-16 Invitrogen Corporation Nucleic acid molecules containing recombination sites and methods of using the same
EP2268817A2 (en) * 2008-03-14 2011-01-05 Merck Serono S.A. Variation of recombinant expression titres by optimising bacterial ribosome binding sites
GB0920775D0 (en) * 2009-11-26 2010-01-13 King S College Cells
US10947570B2 (en) 2016-07-25 2021-03-16 Inv Nylon Chemicals Americas, Llc Materials and methods utilizing biotin producing mutant hosts for the production of 7-carbon chemicals
KR102712136B1 (ko) * 2021-11-15 2024-09-27 씨제이제일제당 (주) 바이오틴 신타제 활성을 갖는 폴리펩티드 변이체 및 이를 이용한 바이오틴 생산 방법
CN118956783B (zh) * 2024-10-18 2024-12-17 北京量维生物科技研究院有限公司 脱硫生物素合成酶突变体及其在生物素生产中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0740922B2 (ja) * 1985-03-05 1995-05-10 株式会社資生堂 ビオチン生産性微生物
US5110731A (en) * 1985-08-26 1992-05-05 Amgen, Inc. System for biotin synthesis
CA1317245C (en) * 1985-08-26 1993-05-04 Eric F. Fisher System for biotin synthesis
JPS62155081A (ja) * 1985-12-27 1987-07-10 Shiseido Co Ltd 新規微生物およびそれを用いる醗酵法によるビオチンの製造法
AU616380B2 (en) * 1986-09-30 1991-10-31 Transgene S.A. Cloning of the bioA, bioD, bioF, bioC, and bioH genes of Bacillus sphaericus, vectors and transformed cells and method for preparing biotin
CA1322735C (en) * 1987-11-07 1993-10-05 Shinichiro Haze Microorganism having low acetate forming capability, and process for production of useful substrate using same
GB2216530B (en) * 1988-03-22 1992-07-08 Mini Agriculture & Fisheries Genetic material for expression of biotin synthetase enzymes
JP3006847B2 (ja) * 1990-03-27 2000-02-07 株式会社資生堂 新規微生物およびそれを用いるビオチン類の製造方法
JPH04169180A (ja) * 1990-11-02 1992-06-17 Shiseido Co Ltd 新規微生物及びそれを用いるビオチン活性物質の製造方法
JP3290473B2 (ja) * 1991-09-13 2002-06-10 株式会社資生堂 ビオチンオペロン
JP3192704B2 (ja) * 1991-10-17 2001-07-30 株式会社資生堂 デスチオビオチンからビオチンへの変換方法
US5374543A (en) * 1992-10-02 1994-12-20 Amgen Inc. Enhanced indole biosynthesis
US5445952A (en) * 1993-01-22 1995-08-29 Basf Aktiengesellschaft Method to produce biotin

Also Published As

Publication number Publication date
KR100200542B1 (ko) 1999-06-15
HU219827B (hu) 2001-08-28
JP3577075B2 (ja) 2004-10-13
FI951547L (fi) 1995-03-31
CA2145400A1 (en) 1994-04-14
FI117515B (fi) 2006-11-15
JP2004000283A (ja) 2004-01-08
CZ285533B6 (cs) 1999-08-11
WO1994008023A3 (de) 1994-06-23
CA2145400C (en) 2005-08-09
KR950703648A (ko) 1995-09-20
DK0667909T3 (da) 1998-09-23
HU9500951D0 (en) 1995-05-29
CZ80995A3 (en) 1995-09-13
EP0798384A1 (de) 1997-10-01
EP0667909B1 (de) 1998-02-11
AU4820293A (en) 1994-04-26
FI951547A0 (fi) 1995-03-31
ATE163198T1 (de) 1998-02-15
PL308301A1 (en) 1995-07-24
HUT71781A (en) 1996-02-28
JP3566287B2 (ja) 2004-09-15
WO1994008023A2 (de) 1994-04-14
EP0667909A1 (de) 1995-08-23
JPH08501694A (ja) 1996-02-27
DE59308149D1 (de) 1998-03-19
SK42095A3 (en) 1995-11-08
PL177635B1 (pl) 1999-12-31
SK279669B6 (sk) 1999-02-11
PL179166B1 (pl) 2000-07-31
US6083712A (en) 2000-07-04

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