ES2115830T3 - L-prolina-3-hidroxilasa y procedimiento de preparacion de cis-hidroxi-3-l-prolina. - Google Patents

L-prolina-3-hidroxilasa y procedimiento de preparacion de cis-hidroxi-3-l-prolina.

Info

Publication number
ES2115830T3
ES2115830T3 ES94113948T ES94113948T ES2115830T3 ES 2115830 T3 ES2115830 T3 ES 2115830T3 ES 94113948 T ES94113948 T ES 94113948T ES 94113948 T ES94113948 T ES 94113948T ES 2115830 T3 ES2115830 T3 ES 2115830T3
Authority
ES
Spain
Prior art keywords
proline
hydroxy
cis
hydroxylase
prolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94113948T
Other languages
English (en)
Inventor
Akio Ozaki
Hideo Mori
Takeshi Shibasaki
Katsuhiko Ando
Keiko Ochiai
Shigeru Chiba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of ES2115830T3 publication Critical patent/ES2115830T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • C12Y114/11002—Procollagen-proline dioxygenase (1.14.11.2), i.e. proline-hydroxylase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PROPORCIONA UN PROCESO PARA PRODUCIR INDUSTRIALMENTE CIS-3HIDROXI-L-PROLINA USADA COMO UN MATERIAL EN BRUTO PARA MEDICINAS O COMO UN ADITIVO PARA ALIMENTOS. L-PROLINA ES CONVERTIDA EN CIS-3HIDROXI-L-PROLINA EN LA PRESENCIA DE UNA FUENTE DE ENZIMA QUE ES DERIVADA DE UN MICROORGANISMO PERTENECIENTE AL GENERO STREPTOMYCES O BACILLUS Y QUE CATALIZA LA HIDROXILACION DE L-PROLINA A CIS-3HIDROXI-L-PROLINA, UN ION DE HIERRO DIVALENTE Y ACIDO 2CETOGLUTARICO, EN UN MEDIO ACUOSO, Y LA CIS-3-HIDROXI-L-PROLINA PRODUCIDA ES RECUPERADA DEL MEDIO ACUOSO. TAMBIEN SE PROPORCIONA UNA NUEVA ENZIMA L-PROLINA-3-HIDROXILASA, QUE SE USA PARA EL PROCESO.
ES94113948T 1993-09-07 1994-09-06 L-prolina-3-hidroxilasa y procedimiento de preparacion de cis-hidroxi-3-l-prolina. Expired - Lifetime ES2115830T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22194193 1993-09-07

Publications (1)

Publication Number Publication Date
ES2115830T3 true ES2115830T3 (es) 1998-07-01

Family

ID=16774558

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94113948T Expired - Lifetime ES2115830T3 (es) 1993-09-07 1994-09-06 L-prolina-3-hidroxilasa y procedimiento de preparacion de cis-hidroxi-3-l-prolina.

Country Status (9)

Country Link
EP (1) EP0645457B1 (es)
KR (1) KR100356927B1 (es)
CN (4) CN1085254C (es)
AT (1) ATE164628T1 (es)
DE (1) DE69409320T2 (es)
DK (1) DK0645457T3 (es)
ES (1) ES2115830T3 (es)
GR (1) GR3026604T3 (es)
HK (1) HK1000714A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2189675C (en) * 1995-03-07 2007-12-11 Akio Ozaki Process for producing cis-3-hydroxy-l-proline
KR100363395B1 (ko) * 2000-04-17 2002-12-02 국방과학연구소 기계적 합금화와 이단계 급속소결에 의한 초미세결정립텅스텐 중합금의 제조방법
CN110804596B (zh) * 2018-08-06 2021-12-28 中国科学院天津工业生物技术研究所 一种新型的脯氨酸3-羟化酶及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0190350A1 (en) * 1984-07-31 1986-08-13 NAGAI, Yoshiki Process for preparing human proline hydroxylase
US5374542A (en) * 1991-08-26 1994-12-20 Kyowa Hakko Kogyo Co., Ltd. Process for producing 4-hydroxy-L-proline

Also Published As

Publication number Publication date
CN1609192A (zh) 2005-04-27
DE69409320D1 (de) 1998-05-07
EP0645457B1 (en) 1998-04-01
CN1106458A (zh) 1995-08-09
CN1990855A (zh) 2007-07-04
EP0645457A2 (en) 1995-03-29
CN1375555A (zh) 2002-10-23
CN1085254C (zh) 2002-05-22
HK1075063A1 (en) 2005-12-02
HK1109782A1 (zh) 2008-06-20
HK1000714A1 (en) 2000-03-17
DK0645457T3 (da) 1998-12-07
GR3026604T3 (en) 1998-07-31
KR950008693A (ko) 1995-04-19
ATE164628T1 (de) 1998-04-15
CN100451107C (zh) 2009-01-14
CN1328370C (zh) 2007-07-25
CN1184311C (zh) 2005-01-12
DE69409320T2 (de) 1998-11-12
EP0645457A3 (en) 1996-04-17
KR100356927B1 (ko) 2003-01-24

Similar Documents

Publication Publication Date Title
ES2164675T3 (es) Procedimiento para producir trans-4-hidroxi-l-prolina.
EP0625571A3 (de) Neue Mikroorganismen, deren Verwendung und Verfahren zur Herstellung von L-Alpha-Aminosäuren.
DK0826773T3 (da) Fremgangsmåde til fremstilling af trans-4-hydroxy-L-prolin
EP0152948A3 (en) Process for the preparation of 6-hydroxynicotinic acid
GB8606120D0 (en) Process
CA2235590A1 (en) Improved microbial production of indigo
GR3021357T3 (en) Production of vanillin by bioconversion of benzenic precursors
GR3034835T3 (en) Enzymatic hydroxylation process for the preparation of HMG-COA reductase inhibitors and intermediates thereof.
ES2115830T3 (es) L-prolina-3-hidroxilasa y procedimiento de preparacion de cis-hidroxi-3-l-prolina.
HUT59727A (en) Improved enzymatic oxidizing process for producing glutaryl-7-amino-cephalosporanic acid from cephalosporin c
CA2253977A1 (en) Process for the preparation of amino alcohols and derivatives thereof
CA2131776A1 (en) Process for producing cis-3-hydroxy-l-proline
CA2131775A1 (en) Process for producing trans-4-hydroxy-l-proline
ES521943A0 (es) Un procedimiento de produccion de glucosa deshidrogenasa.
HUT67685A (en) Process for production of biotin
ZA89304B (en) Method for increasing enzyme activities and synthesis performance of organisms
Ozaki et al. Process for producing trans-4-hydroxy-l-proline
EP0323068A3 (en) Enzymatic carbon-carbon bond formation
IL101172A0 (en) Process for the preparation of ma

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 645457

Country of ref document: ES