ES2116601T3 - Derivados de isoquinolina como agentes terapeuticos. - Google Patents
Derivados de isoquinolina como agentes terapeuticos.Info
- Publication number
- ES2116601T3 ES2116601T3 ES94920931T ES94920931T ES2116601T3 ES 2116601 T3 ES2116601 T3 ES 2116601T3 ES 94920931 T ES94920931 T ES 94920931T ES 94920931 T ES94920931 T ES 94920931T ES 2116601 T3 ES2116601 T3 ES 2116601T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- atoms
- alchyl
- halo
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title abstract 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 101100020619 Arabidopsis thaliana LATE gene Proteins 0.000 abstract 1
- 208000012661 Dyskinesia Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
COMPUESTOS DE TETRAHIDROISOQUINOLINA DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES EN LA QUE : R{SUB,1} REPRESENTA UNO O MAS SUSTITUYENTES ELEGIDOS ENTRE H, HALO HIDROXI, ALQUILO (OPCIONALMENTE SUSTITUIDO POR HIDROXI), ALCOXI ALQUILTIO, ALQUILSULFINILO, ALQUILSULFONILO, NITRO , CIANO, POLIHALOALQUILO, POLIHALOALCOXI, FENILO (OPCIONALENTE SUSTITUIDO POR UNO O MAS DE HALO, ALQUILO O ALCOXI), O R{SUB,1} ES OPCIONALMENTE CARBAMOILO ALQUILADO ; R{SUB,2} UN GRUPO ALIFATICO INSATURADO O SATURADO OPCIONALEMNTE POR HIDROXI O ALCOXI; E REPRESENTA UNA CADENA ALQUILENO OPCIONALMENTE SUSTITUIDA POR UNO OMAS GRUPOS ALQUILO; Y G REPRESENTA (A) UN GRUPO ALICICLICO SATURADO O INSATURADO OPCIONALMENTE SUSTITUIDO QUE CONTIENE 3 A 8 ATOMOS DE CARBONO O (B) CADENA ALIFATICA INSTAURADA O SATRUADA SUSTITUIDA QUE CONTIENEN 1 A 12 ATOMOS DE CARBONO, O (C) UN NUCLEO HETEROCICLICO DE 6 O 5 ELEMENTOS OPCIONALMENTE SUSITUIDO QUE CONTIENE UNO O MAS ATOMOS DE N O O O GRUPOS SO{SUB,N} EN LOS QUE N ES 0,1 O 2; YSUS DERIVADOS O-ACILADOS QUE PROPORCIONAN ESTERES LIPOFILICOS QUE TIENE UTILIDAD ANALGESICA O EN EL TRATAMIENTO DE SICOSIS (POR EJEMPLO SICOFRENIA), ENFERMEDAD DE PARKINSON, SINDROME DE LESCH.NYAN, TRASTORNO DE DEICIT DE ATENCIÑON O TRASTORNS COGNITIVOS O EN EL ALIVIO DE LA DEPENDENCIA DE DROGAS O DISQUINESIA TARDIA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939312807A GB9312807D0 (en) | 1993-06-22 | 1993-06-22 | Therapeutic agents |
| GB939312808A GB9312808D0 (en) | 1993-06-22 | 1993-06-22 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2116601T3 true ES2116601T3 (es) | 1998-07-16 |
Family
ID=26303101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94920931T Expired - Lifetime ES2116601T3 (es) | 1993-06-22 | 1994-06-10 | Derivados de isoquinolina como agentes terapeuticos. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US5807868A (es) |
| EP (1) | EP0707570B1 (es) |
| JP (1) | JPH08511549A (es) |
| CN (1) | CN1046713C (es) |
| AT (1) | ATE165823T1 (es) |
| AU (1) | AU679765B2 (es) |
| BG (1) | BG62403B1 (es) |
| BR (1) | BR9406897A (es) |
| CA (1) | CA2165823A1 (es) |
| CZ (1) | CZ290661B6 (es) |
| DE (1) | DE69410093T2 (es) |
| DK (1) | DK0707570T3 (es) |
| ES (1) | ES2116601T3 (es) |
| FI (1) | FI956150A0 (es) |
| HU (1) | HU211157A9 (es) |
| LV (1) | LV11323A (es) |
| MY (1) | MY111699A (es) |
| NO (1) | NO305434B1 (es) |
| NZ (1) | NZ268587A (es) |
| PL (1) | PL177947B1 (es) |
| RO (1) | RO117377B1 (es) |
| RU (1) | RU2135472C1 (es) |
| SK (1) | SK280108B6 (es) |
| TW (1) | TW353658B (es) |
| UA (1) | UA42730C2 (es) |
| WO (1) | WO1995000489A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9524681D0 (en) | 1995-12-02 | 1996-01-31 | Knoll Ag | Chemical process |
| AU745081B2 (en) | 1997-06-27 | 2002-03-14 | Fujisawa Pharmaceutical Co., Ltd. | Sulfonamide compounds and medicinal use thereof |
| EP1023269A4 (en) * | 1997-09-30 | 2001-06-27 | Molecular Design Int | BETA3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USE |
| BRPI0109200B8 (pt) * | 2000-03-14 | 2021-05-25 | Actelion Pharmaceuticals Ltd | compostos e composições farmacêuticas |
| DE10041478A1 (de) | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
| US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
| US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
| PT1812399E (pt) * | 2004-11-04 | 2010-02-03 | Mallinckrodt Baker Inc | Intermediários opiato e métodos de síntese |
| US7622586B2 (en) * | 2005-10-21 | 2009-11-24 | Mallinckrodt Inc. | Opiate intermediates and methods of synthesis |
| US7511060B2 (en) | 2005-10-21 | 2009-03-31 | Mallinckrodt Inc. | Opiate intermediates and methods of synthesis |
| CN105585527B (zh) * | 2015-12-17 | 2018-06-26 | 浙江工业大学 | 2-(3,4-二氢异喹啉-1(2h)-亚基)乙腈类化合物及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR868733A (fr) * | 1939-10-14 | 1942-01-14 | Troponwerke Dinklage & Co | Procédé pour la fabrication des composés d'isoquinoleine |
| CH420086A (de) * | 1962-01-19 | 1966-09-15 | Hoffmann La Roche | Verfahren zur Herstellung von Tetrahydroisochinolin-Derivaten |
| JPS5734275B2 (es) * | 1973-07-30 | 1982-07-22 | ||
| IL63918A0 (en) * | 1980-10-17 | 1981-12-31 | Pennwalt Corp | N-(amino(or hydroxy)phenethyl)-1,2,3,4-tetrahydroisoquinolines,their preparation and pharmaceutical compositions containing them |
| US4766131A (en) * | 1980-10-17 | 1988-08-23 | Pennwalt Corporation | 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics |
| US4375471A (en) * | 1981-02-19 | 1983-03-01 | Hoechst-Roussel Pharmaceuticals Inc. | 4-Aryloxy-1,2,3,4-tetrahydroisoquinolines |
| GB8501192D0 (en) * | 1985-01-17 | 1985-02-20 | Boots Co Plc | Therapeutic agents |
| GB8921304D0 (en) * | 1989-09-20 | 1989-11-08 | Wyeth John & Brother Ltd | New method of treatment and heterocyclic compounds used therein |
| JP2716548B2 (ja) * | 1989-11-01 | 1998-02-18 | 雅昭 廣部 | パーキンソニズム予防・治療剤 |
| GB9127306D0 (en) * | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
-
1994
- 1994-06-10 DK DK94920931T patent/DK0707570T3/da active
- 1994-06-10 JP JP7502404A patent/JPH08511549A/ja not_active Ceased
- 1994-06-10 BR BR9406897A patent/BR9406897A/pt not_active Application Discontinuation
- 1994-06-10 US US08/564,156 patent/US5807868A/en not_active Expired - Fee Related
- 1994-06-10 PL PL94312251A patent/PL177947B1/pl unknown
- 1994-06-10 DE DE69410093T patent/DE69410093T2/de not_active Expired - Fee Related
- 1994-06-10 RU RU96102846/04A patent/RU2135472C1/ru not_active IP Right Cessation
- 1994-06-10 AU AU71851/94A patent/AU679765B2/en not_active Ceased
- 1994-06-10 UA UA96010210A patent/UA42730C2/uk unknown
- 1994-06-10 NZ NZ268587A patent/NZ268587A/en unknown
- 1994-06-10 RO RO95-02230A patent/RO117377B1/ro unknown
- 1994-06-10 CZ CZ19953427A patent/CZ290661B6/cs not_active IP Right Cessation
- 1994-06-10 WO PCT/EP1994/001926 patent/WO1995000489A1/en not_active Ceased
- 1994-06-10 CN CN94193000A patent/CN1046713C/zh not_active Expired - Fee Related
- 1994-06-10 ES ES94920931T patent/ES2116601T3/es not_active Expired - Lifetime
- 1994-06-10 CA CA002165823A patent/CA2165823A1/en not_active Abandoned
- 1994-06-10 AT AT94920931T patent/ATE165823T1/de not_active IP Right Cessation
- 1994-06-10 SK SK1604-95A patent/SK280108B6/sk unknown
- 1994-06-10 EP EP94920931A patent/EP0707570B1/en not_active Expired - Lifetime
- 1994-06-16 MY MYPI94001537A patent/MY111699A/en unknown
- 1994-12-21 TW TW083112011A patent/TW353658B/zh active
-
1995
- 1995-06-30 HU HU95P/P00685P patent/HU211157A9/hu unknown
- 1995-12-06 BG BG100195A patent/BG62403B1/bg unknown
- 1995-12-20 FI FI956150A patent/FI956150A0/fi unknown
- 1995-12-21 NO NO955234A patent/NO305434B1/no unknown
-
1996
- 1996-01-22 LV LV960014A patent/LV11323A/xx unknown
-
1997
- 1997-03-27 US US08/826,012 patent/US5804586A/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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