ES2117871T3 - Terapia electroporetica mediante genes y medicamentos, por campos electricos inducidos. - Google Patents

Terapia electroporetica mediante genes y medicamentos, por campos electricos inducidos.

Info

Publication number
ES2117871T3
ES2117871T3 ES95925349T ES95925349T ES2117871T3 ES 2117871 T3 ES2117871 T3 ES 2117871T3 ES 95925349 T ES95925349 T ES 95925349T ES 95925349 T ES95925349 T ES 95925349T ES 2117871 T3 ES2117871 T3 ES 2117871T3
Authority
ES
Spain
Prior art keywords
preselected
blood vessel
cells
molecules
electric fields
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95925349T
Other languages
English (en)
Inventor
Gunter A Hofmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetronics Inc
Original Assignee
Genetronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetronics Inc filed Critical Genetronics Inc
Application granted granted Critical
Publication of ES2117871T3 publication Critical patent/ES2117871T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE FACILITAN UN METODO Y UN APARATO PARA INTRODUCIR MOLECULAS COMO GENES Y COMPUESTOS FARMACEUTICOS EN LAS CELULAS SANGUINEAS VIVAS DE UN PACIENTE PARA PROPOSITOS TERAPEUTICOS. SE COLOCA UN DISPOSITIVO EN CONTACTO CON EL CUERPO DEL PACIENTE PARA GENERAR UN CAMPO ELECTRICO EN UN LUGAR PRESELECCIONADO DENTRO DE UN VASO SANGUINEO SELECCIONADO. LAS MOLECULAS PRESELECCIONADAS SON INFUNDIDAS EN EL VASO SANGUINEO SELECCIONADO. SIMULTANEAMENTE SE APLICA UNA SEÑAL ELECTRICA AL DISPOSITIVO APLICADO PARA SOMETER DE FORMA REPETIDA UNA CANTIDAD DE FLUJO SANGUINEO DENTRO DEL VASO SANGUINEO SELECCIONADO MAS ALLA DEL LUGAR PRESELECCIONADO A CAMPOS ELECTRICOS DE UNA AMPLITUD Y DURACION PREDETERMINADOS. LOS PARAMETROS DE LOS CAMPOS ELECTRICOS SON CONTROLADOS PRECISAMENTE PARA HACER QUE LAS PAREDES DE LAS CELULAS PRESELECCIONADAS DE LA SANGRE PERMEABLES DE FORMA TRANSITORIA Y PERMITIR QUE LAS MOLECULAS ENTREN EN DICHAS CELULAS PRESELECCIONADAS SIN MATARLAS. EL DISPOSITIVO PUEDE INCLUIR UNA BOBINA DE INDUCCIONQUE COLOCADA EN CONTACTO CON EL CUERPO SOBRE UN VASO SANGUINEO, O ALTERNATIVAMENTE, UNA BOBINA DE INDUCCION QUE RODEA EL VASO SANGUINEO. LA SEÑAL ELECTRICA ES SUMINISTRADA POR UN PAQUETE ENERGETICO Y LAS MOLECULAS PRESELECCIONADAS SE INFUNDE CON UNA BOMBA DE SUMINISTRO.
ES95925349T 1994-10-25 1995-06-27 Terapia electroporetica mediante genes y medicamentos, por campos electricos inducidos. Expired - Lifetime ES2117871T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/328,895 US6132419A (en) 1992-05-22 1994-10-25 Electroporetic gene and drug therapy

Publications (1)

Publication Number Publication Date
ES2117871T3 true ES2117871T3 (es) 1998-08-16

Family

ID=23282925

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95925349T Expired - Lifetime ES2117871T3 (es) 1994-10-25 1995-06-27 Terapia electroporetica mediante genes y medicamentos, por campos electricos inducidos.

Country Status (8)

Country Link
US (1) US6132419A (es)
EP (1) EP0788392B1 (es)
AT (1) ATE166585T1 (es)
AU (1) AU2951595A (es)
DE (1) DE69502733T2 (es)
DK (1) DK0788392T3 (es)
ES (1) ES2117871T3 (es)
WO (1) WO1996012520A1 (es)

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Also Published As

Publication number Publication date
ATE166585T1 (de) 1998-06-15
EP0788392A1 (en) 1997-08-13
AU2951595A (en) 1996-05-15
EP0788392B1 (en) 1998-05-27
DE69502733T2 (de) 1998-09-24
WO1996012520A1 (en) 1996-05-02
DE69502733D1 (de) 1998-07-02
US6132419A (en) 2000-10-17
DK0788392T3 (da) 1999-03-01

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