ES2119369T3 - Dispositivo sensor para un ensayo sandwich. - Google Patents

Dispositivo sensor para un ensayo sandwich.

Info

Publication number
ES2119369T3
ES2119369T3 ES95902906T ES95902906T ES2119369T3 ES 2119369 T3 ES2119369 T3 ES 2119369T3 ES 95902906 T ES95902906 T ES 95902906T ES 95902906 T ES95902906 T ES 95902906T ES 2119369 T3 ES2119369 T3 ES 2119369T3
Authority
ES
Spain
Prior art keywords
specific binding
binding partner
ligand
zone
known amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95902906T
Other languages
English (en)
Inventor
Grenville Arthur Robinson
Janys Fletcher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Research Systems ARS Holding NV
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Application granted granted Critical
Publication of ES2119369T3 publication Critical patent/ES2119369T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Joints Allowing Movement (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Glass Compositions (AREA)
  • Window Of Vehicle (AREA)
  • Control Of Combustion (AREA)
  • Geophysics And Detection Of Objects (AREA)
  • Investigation Of Foundation Soil And Reinforcement Of Foundation Soil By Compacting Or Drainage (AREA)

Abstract

SE PRESENTAN DISPOSITIVOS SENSORES PARA SU USO EN EL ENSAYO DE UN LIGANTE EN UNA MUESTRA, LOS DISPOSITIVOS COMPRENDEN: I) UNA ZONA DISCRETA ("LA ZONA DE MEDIDA") SOBRE UNA REGION EN LA CUAL ("LA REGION DE MEDIDA") SE INMOVILIZA DIRECTA O INDIRECTAMENTE UN PRIMER COMPAÑERO DE UNION ESPECIFICO PARA EL LIGANTE BAJO ENSAYO (O UN REACTIVO PRECOMPLEJADO CON O CAPAZ DE FORMAR UN COMPLEJO CON UN COMPAÑERO DE UNION ESPECIFICO PARA EL LIGANTE BAJO ENSAYO), LA ZONA CONTIENE ADICIONALMENTE, EN FORMA LIBERABLE, UNA PRIMERA CANTIDAD CONOCIDA DE UN SEGUNDO COMPAÑERO DE UNION ESPECIFICA OPCIONALMENTE ETIQUETADO PARA EL LIGANTE BAJO ENSAYO, EL SEGUNDO COMPAÑERO DE UNION ESPECIFICA SE DIRIGE A UN EPITOPO DEL LIGANTE BAJO ENSAYO DIFERENTE DEL EPITOPO AL CUAL SE DIRIGE EL PRIMER COMPAÑERO DE UNION ESPECIFICA; Y II) UNA SEGUNDA ZONA DISCRETA ("LA ZONA DE REFERENCIA") SOBRE UNA REGION DE LA CUAL SE INMOVILIZA DIRECTA O INDIRECTAMENTE UN PRIMER COMPAÑERO DE UNION ESPECIFICA DEL LIGANTE BAJO ENSAYO (O UN REACTIVOPRECOMPLEJADO CON O CAPAZ DE FORMAR UN COMPLEJO CON UN COMPAÑERO DE UNION ESPECIFICA PARA EL LIGANTE BAJO ENSAYO), LA ZONA ADICIONALMENTE CONTIENE, EN FORMA LIBERABLE, UNA CANTIDAD CONOCIDA DE UN ANALOGO DEL LIGANTE Y SEPARADAMENTE CONTIENE, EN FORMA LIBERABLE, UNA SEGUNDA CANTIDAD CONOCIDA DE UN SEGUNDO COMPAÑERO DE UNION ESPECIFICA OPCIONALMENTE ETIQUETADO PARA EL LIGANTE BAJO ENSAYO SEGUN SE HA DEFINIDO ANTERIORMENTE, LA SEGUNDA CANTIDAD CONOCIDA ES INFERIOR QUE LA MENCIONADA PRIMERA CANTIDAD CONOCIDA EN LA ZONA DE MEDIDA. TAMBIEN SE DESCRIBEN METODOS PARA UN ENSAYO DE ESTRATIFICACION QUE UTILIZA LOS DISPOSITIVOS.
ES95902906T 1993-12-16 1994-12-15 Dispositivo sensor para un ensayo sandwich. Expired - Lifetime ES2119369T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939325718A GB9325718D0 (en) 1993-12-16 1993-12-16 Sensor device for sandwich assay

Publications (1)

Publication Number Publication Date
ES2119369T3 true ES2119369T3 (es) 1998-10-01

Family

ID=10746687

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95902906T Expired - Lifetime ES2119369T3 (es) 1993-12-16 1994-12-15 Dispositivo sensor para un ensayo sandwich.

Country Status (11)

Country Link
US (1) US5856203A (es)
EP (1) EP0734527B1 (es)
JP (1) JP3458860B2 (es)
AT (1) ATE169117T1 (es)
AU (1) AU689174B2 (es)
CA (1) CA2177362C (es)
DE (1) DE69412137T2 (es)
DK (1) DK0734527T3 (es)
ES (1) ES2119369T3 (es)
GB (1) GB9325718D0 (es)
WO (1) WO1995016914A1 (es)

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US7635597B2 (en) * 1995-08-09 2009-12-22 Bayer Healthcare Llc Dry reagent particle assay and device having multiple test zones and method therefor
CA2270665A1 (en) * 1996-11-11 1998-05-22 Novartis Ag Use of biosensors to diagnose plant diseases
SE9704933D0 (sv) * 1997-12-30 1997-12-30 Pharmacia & Upjohn Diag Ab Metod som utnyttjar en ny kalibrator och test kit som innehåller kalibratorn
US6379909B1 (en) * 1998-06-24 2002-04-30 Alk-Abello A/S Method of detecting an antibody in a liquid sample
US6136610A (en) * 1998-11-23 2000-10-24 Praxsys Biosystems, Inc. Method and apparatus for performing a lateral flow assay
US6511814B1 (en) * 1999-03-26 2003-01-28 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
US6602719B1 (en) 1999-03-26 2003-08-05 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
US6551842B1 (en) 1999-03-26 2003-04-22 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
WO2001014823A1 (en) * 1999-08-19 2001-03-01 The Regents Of The University Of California Apparatus and method for visually identifying micro-forces with a palette of cantilever array blocks
JP3759039B2 (ja) * 2000-05-11 2006-03-22 松下エコシステムズ株式会社 化学センサデバイス
DE10043113C2 (de) * 2000-08-31 2002-12-19 Pe Diagnostik Gmbh Verfahren zur Verbesserung der Messgenauigkeit bei Sensoren, insbesondere Bio-Sensoren, die Fluoreszenzstrahlung auswerten
US6689615B1 (en) 2000-10-04 2004-02-10 James Murto Methods and devices for processing blood samples
DE10058579A1 (de) * 2000-11-18 2002-06-13 Sentronic Gmbh Ges Fuer Optisc Vorrichtung und Verfahren zur optischen Messung von Konzentrationen eines Stoffes
US7407746B2 (en) * 2001-02-08 2008-08-05 Ngk Insulators, Ltd. Biochip and method for producing the same
FR2823999B1 (fr) * 2001-04-27 2003-06-27 Commissariat Energie Atomique Dispositif miniature de separation et d'isolement d'objets biologiques et utilisations
US7790439B2 (en) * 2001-08-09 2010-09-07 Panasonic Corporation Biosensor and measurement method
SE0103072D0 (sv) * 2001-09-17 2001-09-17 Pharmacia Diagnostics Ab Multi-analyte assay device with multi-spot detection zone
US20030154149A1 (en) * 2002-02-13 2003-08-14 Dilip Gajendragadkar System and method of creating and executing a restricted stock sale plan
JP3878144B2 (ja) * 2003-03-19 2007-02-07 富士フイルムホールディングス株式会社 生化学解析用ユニット
WO2005001421A2 (en) * 2003-06-05 2005-01-06 Oakland University Improved piezoimmunosensor
US8128871B2 (en) 2005-04-22 2012-03-06 Alverix, Inc. Lateral flow assay systems and methods
DE102004023402A1 (de) * 2004-05-12 2005-12-08 Roche Diagnostics Gmbh Verfahren zur Erhöhung des dynamischen Messbereichs von auf spezifischen Bindereaktionen basierenden, insbesondere immunologischen Testelementen
CA2475240A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to measure dynamic internal calibration true dose response curves
CA2475456A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to optimize analyte and antibody substrate binding by least energy adsorption
CN101031798B (zh) 2004-07-29 2012-06-27 瑞莱诊断体系有限公司 侧向流系统和测定
JPWO2006043387A1 (ja) * 2004-09-28 2008-05-22 第一化学薬品株式会社 検体の免疫学的検査方法及びその方法に用いる検査器具
US20060068501A1 (en) * 2004-09-30 2006-03-30 Nj International Llc Apparatus and methods for steroid hormone testing
TW200617393A (en) * 2004-11-22 2006-06-01 Univ Nat Cheng Kung Method for testing lectin
US7939342B2 (en) 2005-03-30 2011-05-10 Kimberly-Clark Worldwide, Inc. Diagnostic test kits employing an internal calibration system
US9891217B2 (en) 2005-04-22 2018-02-13 Alverix, Inc. Assay test strips with multiple labels and reading same
US7439079B2 (en) * 2005-04-29 2008-10-21 Kimberly-Clark Worldwide, Inc. Assay devices having detection capabilities within the hook effect region
US7829347B2 (en) 2005-08-31 2010-11-09 Kimberly-Clark Worldwide, Inc. Diagnostic test kits with improved detection accuracy
EP1941276A1 (de) * 2005-10-29 2008-07-09 Bayer Technology Services GmbH Verfahren zur bestimmung eines oder mehrerer analyten in komplex zusammengesetzten proben biologischen ursprungs und dessen verwendung
US9557328B2 (en) 2009-06-30 2017-01-31 Koninklijke Philips N.V. Magnetic sensor device, method of operating such a device and sample
HK1199468A1 (en) * 2011-09-08 2015-07-03 Nexus Dx股份有限公司 A multilevel analyte assay
SG10202005917SA (en) * 2015-03-06 2020-07-29 Genentech Inc Ultrapurified dsba and dsbc and methods of making and using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
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US5141868A (en) * 1984-06-13 1992-08-25 Internationale Octrooi Maatschappij "Octropa" Bv Device for use in chemical test procedures
DE3588124T2 (de) * 1984-06-13 1997-02-20 Applied Research Systems Vorrichtung, mit Verwendung in chemischen Prüfverfahren
GB8911462D0 (en) * 1989-05-18 1989-07-05 Ares Serono Res & Dev Ltd Devices for use in chemical test procedures
GB9025471D0 (en) * 1990-11-22 1991-01-09 Ares Serono Res & Dev Ltd Method of assay
CA2069537A1 (en) * 1991-06-07 1992-12-08 Thomas A. Cook Multiple output referencing system for evanescent wave sensor
GB9212302D0 (en) * 1992-06-10 1992-07-22 Applied Research Systems Method for improving measurement precision in evanescent wave optical biosensor assays
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity

Also Published As

Publication number Publication date
CA2177362C (en) 2005-09-20
US5856203A (en) 1999-01-05
AU1198895A (en) 1995-07-03
JP3458860B2 (ja) 2003-10-20
JPH09510774A (ja) 1997-10-28
EP0734527B1 (en) 1998-07-29
WO1995016914A1 (en) 1995-06-22
DE69412137D1 (de) 1998-09-03
EP0734527A1 (en) 1996-10-02
CA2177362A1 (en) 1995-06-22
AU689174B2 (en) 1998-03-26
GB9325718D0 (en) 1994-02-16
DE69412137T2 (de) 1999-01-21
ATE169117T1 (de) 1998-08-15
DK0734527T3 (da) 1999-05-03

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