ES2119872T3 - Procedimiento de preparacion de derivados de beta-lactama y su intermediario de sintesis. - Google Patents

Procedimiento de preparacion de derivados de beta-lactama y su intermediario de sintesis.

Info

Publication number
ES2119872T3
ES2119872T3 ES93400506T ES93400506T ES2119872T3 ES 2119872 T3 ES2119872 T3 ES 2119872T3 ES 93400506 T ES93400506 T ES 93400506T ES 93400506 T ES93400506 T ES 93400506T ES 2119872 T3 ES2119872 T3 ES 2119872T3
Authority
ES
Spain
Prior art keywords
group
beta
formula
lactama
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93400506T
Other languages
English (en)
Inventor
Hiroshi Horikawa
Kazuhiko Kondo
Tameo Iwasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2119872T3 publication Critical patent/ES2119872T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
    • G11B27/00—Editing; Indexing; Addressing; Timing or synchronising; Monitoring; Measuring tape travel
    • G11B27/10—Indexing; Addressing; Timing or synchronising; Measuring tape travel
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE MUESTRA UN PROCESO PARA PREPARAR UN COMPUESTO (BETA)-LACTAMA REPRESENTADO POR LA FORMULA: DONDE R1 REPRESENTA UN GRUPO AMINO O GRUPO ALQUILO INFERIOR HIDROXI-SUSTITUIDO PUDIENDO ESTAR CADA UNO DE ELLOS PROTEGIDO; R2 REPRESENTA UN ATOMO DE HIDROGENO O UN RESIDUO ESTER; X REPRESENTA UN GRUPO METILENO QUE PUEDE ESTAR SUSTITUIDO POR UN GRUPO ALQUILO INFERIOR, UN ATOMO DE AZUFRE O UN GRUPO REPRESENTADO POR LA FORMULA: DONDE A REPRESENTA UN ATOMO DE AZUFRE, UN ATOMO DE OXIGENO O UN GRUPO METILENO; E Y ES BIEN UN W QUE REPRESENTA UN RESIDUO DE ESTER ACTIVO DE UN GRUPO HIDROXILO, O UN R4 QUE ES UN GRUPO ORGANICO, O UN SAL CONSIGUIENTE, QUE COMPRENDE LOS PASOS DE TRATAR UN COMPUESTO 1 NTES REPRESENTADO POR LA FORMULA: O UNA SAL CONSIGUIENTE CON UNA BASE EN PRESENCIA DE UN AGENTE DESULFURANTE Y LUEGO REACCIONAR EL COMPUESTO RESULTANTE CON UN AGENTE ESTERIFICANTE ACTIVO DE GRUPO HIDROXILO, Y, SI ES NECESARIO, TRATAR ADICIONALMENTE EL COMPUESTO (BETA)-LACTAMA CON UN COMPUESTO R4 - SH.
ES93400506T 1992-03-06 1993-02-26 Procedimiento de preparacion de derivados de beta-lactama y su intermediario de sintesis. Expired - Lifetime ES2119872T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4099023A JP2569455B2 (ja) 1992-03-06 1992-03-06 β−ラクタム誘導体の製法

Publications (1)

Publication Number Publication Date
ES2119872T3 true ES2119872T3 (es) 1998-10-16

Family

ID=14235638

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93400506T Expired - Lifetime ES2119872T3 (es) 1992-03-06 1993-02-26 Procedimiento de preparacion de derivados de beta-lactama y su intermediario de sintesis.

Country Status (12)

Country Link
US (2) US5414081A (es)
EP (1) EP0559533B1 (es)
JP (1) JP2569455B2 (es)
KR (1) KR930019673A (es)
AT (1) ATE168693T1 (es)
CA (1) CA2085540A1 (es)
DE (1) DE69319764T2 (es)
DK (1) DK0559533T3 (es)
ES (1) ES2119872T3 (es)
GR (1) GR3027788T3 (es)
SG (1) SG46231A1 (es)
TW (1) TW249233B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0612749T3 (da) * 1993-02-12 2003-08-04 Daiichi Suntory Pharma Co Ltd Fremgangsmåde til desilylering af silyletherforbindelser
US6769128B1 (en) 1995-06-07 2004-07-27 United Video Properties, Inc. Electronic television program guide schedule system and method with data feed access
EP1036466B1 (en) 1997-07-21 2003-03-26 E Guide, Inc. Method for navigating within a television program guide having advertisements
US6111144A (en) 1997-08-21 2000-08-29 Florida State University Method for the synthesis of a taxane intermediate
US6763522B1 (en) 1998-06-30 2004-07-13 Sony Corporation System and method for a digital television electronic program guide
US6898762B2 (en) 1998-08-21 2005-05-24 United Video Properties, Inc. Client-server electronic program guide
US20040002600A1 (en) * 2002-06-20 2004-01-01 Orchid Chemicals And Pharmaceuticals Limited Process for the conversion of penam ring system to cepham ring system
WO2004035539A1 (ja) * 2002-10-18 2004-04-29 Meiji Seika Kaisha, Ltd. カルバペネム類の製造方法およびその製造に用いられる中間体
JPWO2004043961A1 (ja) * 2002-11-13 2006-03-09 株式会社カネカ 経口投与用カルバペネム化合物の製造方法
CN100347179C (zh) * 2002-11-13 2007-11-07 株式会社钟化 经口给药用碳青霉素烯化合物的新的合成中间体及其制造方法
WO2005005446A1 (ja) * 2003-07-11 2005-01-20 Nippon Soda Co., Ltd. カルバペネム中間体の製造方法
JP5016480B2 (ja) * 2005-03-29 2012-09-05 株式会社カネカ 結晶形態の１β−メチルカルバペネム中間体
HU227443B1 (en) * 2007-10-18 2011-06-28 Pannon Egyetem Multifunction-compatibilisation package of additives for plastic and rubber compositions
KR20110049823A (ko) * 2008-07-30 2011-05-12 랜박시 래보러터리스 리미티드 카르바페넴 화합물의 제조 방법
US8235923B2 (en) 2008-09-30 2012-08-07 Tyco Healthcare Group Lp Compression device with removable portion
US9166714B2 (en) 2009-09-11 2015-10-20 Veveo, Inc. Method of and system for presenting enriched video viewing analytics
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
US10695322B2 (en) 2016-01-29 2020-06-30 The Johns Hopkins University Inhibitors of bacterial growth

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
US4782145A (en) * 1986-06-02 1988-11-01 Pfizer Inc. Process for penem derivatives
CA2050255C (en) * 1990-09-07 1997-02-04 Tameo Iwasaki 1-methylcarbapenem derivatives and process for preparation thereof

Also Published As

Publication number Publication date
JP2569455B2 (ja) 1997-01-08
DE69319764T2 (de) 1998-11-26
US5414081A (en) 1995-05-09
KR930019673A (ko) 1993-10-18
US5589592A (en) 1996-12-31
EP0559533A1 (en) 1993-09-08
EP0559533B1 (en) 1998-07-22
DE69319764D1 (de) 1998-08-27
SG46231A1 (en) 1998-02-20
JPH05279367A (ja) 1993-10-26
CA2085540A1 (en) 1993-09-07
GR3027788T3 (en) 1998-11-30
TW249233B (es) 1995-06-11
ATE168693T1 (de) 1998-08-15
DK0559533T3 (da) 1998-12-14

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