ES2120174T3 - Aparato y procedimiento de ciclado termico de dosificados de acidos nucleicos. - Google Patents
Aparato y procedimiento de ciclado termico de dosificados de acidos nucleicos.Info
- Publication number
- ES2120174T3 ES2120174T3 ES95906818T ES95906818T ES2120174T3 ES 2120174 T3 ES2120174 T3 ES 2120174T3 ES 95906818 T ES95906818 T ES 95906818T ES 95906818 T ES95906818 T ES 95906818T ES 2120174 T3 ES2120174 T3 ES 2120174T3
- Authority
- ES
- Spain
- Prior art keywords
- temperature
- constant
- dosages
- procedure
- nucleic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 238000005382 thermal cycling Methods 0.000 title 1
- 239000012530 fluid Substances 0.000 abstract 4
- 238000011330 nucleic acid test Methods 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D23/00—Control of temperature
- G05D23/01—Control of temperature without auxiliary power
- G05D23/13—Control of temperature without auxiliary power by varying the mixing ratio of two fluids having different temperatures
- G05D23/138—Control of temperature without auxiliary power by varying the mixing ratio of two fluids having different temperatures for gases
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D23/00—Control of temperature
- G05D23/19—Control of temperature characterised by the use of electric means
- G05D23/1919—Control of temperature characterised by the use of electric means characterised by the type of controller
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/115831—Condition or time responsive
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
- Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/12—Condition responsive control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Automation & Control Theory (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Control Of Temperature (AREA)
Abstract
SE PRESENTA UN APARATO Y UN METODO PARA LA CICLACION TERMICA DE ENSAYOS DE ACIDO NUCLEICO QUE INCLUYE UNA CORRIENTE DE FLUIDO MEZCLADA PRODUCIDA A PARTIR DE UNA PLURALIDAD DE CORRIENTES DE FLUIDO DE TEMPERATURA CONSTANTE, VOLUMEN CONSTANTE Y VELOCIDAD CONSTANTE Y TEMPERATURA VARIABLE, QUE SE INTRODUCE EN EL INTERIOR DE UNA CAMARA DE MUESTRAS PARA CALENTAR Y ENFRIAR LAS MUESTRAS CONTENIDAS EN LAS MISMAS. DESVIANDO Y ALTERANDO LA PROPORCION DE LAS CORRIENTES DE FLUIDO DE TEMPERATURA CONSTANTE UNAS CON RELACION A LAS OTRAS, LA CORRIENTE DE FLUIDO MEZCLADO ES RAPIDAMENTE VARIABLE EN TEMPERATURA, SUMINISTRANDO UN CAMBIO DE TEMPERATURA CASI INSTANTANEO DENTRO DEL MEDIO AMBIENTE DEFINIDO POR LA CAMARA DE MUESTRAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17984594A | 1994-01-11 | 1994-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2120174T3 true ES2120174T3 (es) | 1998-10-16 |
Family
ID=22658217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95906818T Expired - Lifetime ES2120174T3 (es) | 1994-01-11 | 1995-01-11 | Aparato y procedimiento de ciclado termico de dosificados de acidos nucleicos. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5576218A (es) |
| EP (1) | EP0739241B1 (es) |
| JP (1) | JPH09508224A (es) |
| AT (1) | ATE169521T1 (es) |
| AU (1) | AU1527095A (es) |
| CA (1) | CA2178644A1 (es) |
| DE (1) | DE69504031T2 (es) |
| ES (1) | ES2120174T3 (es) |
| WO (1) | WO1995018676A1 (es) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9618595D0 (en) * | 1996-09-06 | 1996-10-16 | Central Research Lab Ltd | Reaction cell |
| US6210882B1 (en) | 1998-01-29 | 2001-04-03 | Mayo Foundation For Medical Education And Reseach | Rapid thermocycling for sample analysis |
| US7799521B2 (en) | 1998-06-24 | 2010-09-21 | Chen & Chen, Llc | Thermal cycling |
| JP4321738B2 (ja) | 1998-06-24 | 2009-08-26 | チェン アンド チェン エルエルシー | 液体試料試験システム |
| US6780617B2 (en) | 2000-12-29 | 2004-08-24 | Chen & Chen, Llc | Sample processing device and method |
| US6472186B1 (en) * | 1999-06-24 | 2002-10-29 | Andre Quintanar | High speed process and apparatus for amplifying DNA |
| FI110817B (fi) * | 2000-02-01 | 2003-03-31 | Waertsilae Tech Oy Ab | Lämmöntalteenottolaitteisto ja menetelmä likaantumisen minimoimiseksi lämmöntalteenottolaitteistossa |
| US6627159B1 (en) | 2000-06-28 | 2003-09-30 | 3M Innovative Properties Company | Centrifugal filling of sample processing devices |
| US6734401B2 (en) | 2000-06-28 | 2004-05-11 | 3M Innovative Properties Company | Enhanced sample processing devices, systems and methods |
| US6720187B2 (en) | 2000-06-28 | 2004-04-13 | 3M Innovative Properties Company | Multi-format sample processing devices |
| NZ526793A (en) * | 2001-01-02 | 2006-02-24 | Supachill Technologies Pty Ltd | Method and system for preparing tissue samples for histological pathological examination |
| EP1252931A1 (en) * | 2001-04-26 | 2002-10-30 | Centre National de Genotypage | Thermal cycle device for amplification of nucleic acid sequences |
| CA2460192C (en) | 2001-09-11 | 2011-04-19 | Iquum, Inc. | Sample vessels |
| US6904968B2 (en) * | 2001-09-14 | 2005-06-14 | Hewlett-Packard Development Company, L.P. | Method and apparatus for individually cooling components of electronic systems |
| HUP0401479A2 (en) * | 2001-09-20 | 2004-10-28 | Dimensional Pharmaceuticals 3 | Multi-well microtiter plate made from thermall conductive plastic |
| US6889468B2 (en) | 2001-12-28 | 2005-05-10 | 3M Innovative Properties Company | Modular systems and methods for using sample processing devices |
| US7179639B2 (en) * | 2002-03-05 | 2007-02-20 | Raveendran Pottathil | Thermal strip thermocycler |
| US20040241723A1 (en) * | 2002-03-18 | 2004-12-02 | Marquess Foley Leigh Shaw | Systems and methods for improving protein and milk production of dairy herds |
| JP2005523692A (ja) | 2002-04-26 | 2005-08-11 | アボット・ラボラトリーズ | 生物学的検定において磁性粒子を処理するための構造体および方法 |
| CA2515075C (en) | 2003-02-05 | 2012-10-02 | Iquum, Inc. | Sample processing |
| EP1606419A1 (en) | 2003-03-18 | 2005-12-21 | Quantum Genetics Ireland Limited | Systems and methods for improving protein and milk production of dairy herds |
| DE10313898A1 (de) * | 2003-03-27 | 2004-10-07 | Siemens Ag | PCR-Gerät |
| WO2005011867A2 (en) | 2003-07-31 | 2005-02-10 | Handylab, Inc. | Processing particle-containing samples |
| US7025672B2 (en) * | 2003-08-01 | 2006-04-11 | Honeywell International Inc. | Bi-directional connections for daisy-chained dampers |
| WO2005112544A2 (en) | 2004-02-19 | 2005-12-01 | The Governors Of The University Of Alberta | Leptin promoter polymorphisms and uses thereof |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| US7670834B2 (en) * | 2004-06-23 | 2010-03-02 | Applied Biosystems, Llc | Gas thermal cycler |
| JP4820979B2 (ja) * | 2004-10-12 | 2011-11-24 | 国立大学法人広島大学 | 細胞培養装置 |
| US20060094028A1 (en) * | 2004-11-04 | 2006-05-04 | Welch Allyn, Inc. | Rapid diagnostic assay |
| US7763210B2 (en) | 2005-07-05 | 2010-07-27 | 3M Innovative Properties Company | Compliant microfluidic sample processing disks |
| US7323660B2 (en) | 2005-07-05 | 2008-01-29 | 3M Innovative Properties Company | Modular sample processing apparatus kits and modules |
| US7754474B2 (en) | 2005-07-05 | 2010-07-13 | 3M Innovative Properties Company | Sample processing device compression systems and methods |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| DK3088083T3 (en) | 2006-03-24 | 2018-11-26 | Handylab Inc | Method of carrying out PCR down a multi-track cartridge |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| WO2008060604A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US8709787B2 (en) | 2006-11-14 | 2014-04-29 | Handylab, Inc. | Microfluidic cartridge and method of using same |
| WO2008080106A1 (en) * | 2006-12-21 | 2008-07-03 | University Of Virginia Patent Foundation | Non-contact thermal control of small volume and related apparatus thereof |
| JP4978928B2 (ja) * | 2007-04-27 | 2012-07-18 | シーケーディ株式会社 | 温度制御装置 |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US20100242630A1 (en) * | 2007-08-05 | 2010-09-30 | Al-Qassem Sadeq Ahmad | Sample extraction device |
| US8863595B2 (en) | 2007-08-05 | 2014-10-21 | Kuwait University | Sample extraction device |
| US20090031827A1 (en) * | 2007-08-05 | 2009-02-05 | University Of Kuwait | Smart sample Extraction Device and Method |
| US20090055243A1 (en) | 2007-08-21 | 2009-02-26 | Jayson Lee Lusk | Systems and methods for predicting a livestock marketing method |
| EP2255010B1 (en) * | 2008-02-20 | 2018-05-30 | Streck Inc. | Thermocycler and sample vessel for rapid amplification of dna |
| US20100055733A1 (en) * | 2008-09-04 | 2010-03-04 | Lutolf Matthias P | Manufacture and uses of reactive microcontact printing of biomolecules on soft hydrogels |
| AT10460U3 (de) | 2008-10-30 | 2009-09-15 | Avl List Gmbh | Prüfstands-konditioniersystem für ein arbeitsfluid, sowie vorrichtung zum betreiben eines derartigen prüfstands-konditioniersystems |
| US20100119454A1 (en) * | 2008-11-03 | 2010-05-13 | Ping Shen | Use of the conserved Drosophila NPFR1 system for uncovering interacting genes and pathways important in nociception and stress response |
| JP5172615B2 (ja) * | 2008-11-12 | 2013-03-27 | Ckd株式会社 | 温度制御装置 |
| WO2010132756A2 (en) * | 2009-05-14 | 2010-11-18 | Streck, Inc. | Sample processing cassette, system, and method |
| US8834792B2 (en) | 2009-11-13 | 2014-09-16 | 3M Innovative Properties Company | Systems for processing sample processing devices |
| ES2769028T3 (es) | 2011-04-15 | 2020-06-24 | Becton Dickinson Co | Termociclador microfluídico de barrido en tiempo real |
| US9168523B2 (en) | 2011-05-18 | 2015-10-27 | 3M Innovative Properties Company | Systems and methods for detecting the presence of a selected volume of material in a sample processing device |
| CN103501908B (zh) | 2011-05-18 | 2016-03-16 | 3M创新有限公司 | 用于样品处理装置上阀调的系统和方法 |
| AU2012255144B2 (en) | 2011-05-18 | 2015-01-29 | Diasorin Italia S.P.A. | Systems and methods for volumetric metering on a sample processing device |
| WO2012166913A1 (en) | 2011-06-01 | 2012-12-06 | Streck, Inc. | Rapid thermocycler system for rapid amplification of nucleic acids and related methods |
| CN102872927A (zh) * | 2011-07-11 | 2013-01-16 | 徐州润物科技发展有限公司 | 一种置换式恒温槽 |
| CN103946398B (zh) | 2011-09-15 | 2019-08-13 | 健能泰格技术公司 | 探针:反义探针组合物对高特异性dna或rna的检测 |
| CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
| GB2502585A (en) * | 2012-05-31 | 2013-12-04 | Stratec Biomedical Ag | Method and Device for Regulating the Temperature of a Sample |
| EP2883039A1 (en) | 2012-08-10 | 2015-06-17 | Streck Inc. | Real-time optical system for polymerase chain reaction |
| EP3014251A1 (en) | 2013-06-28 | 2016-05-04 | Streck Inc. | Devices for real-time polymerase chain reaction |
| BR102013020286A2 (pt) * | 2013-08-08 | 2015-08-11 | Odeme Equipamentos Médicos e Odontológicos Ltda | Processo e equipamento para teste de ciclagem térmica de materiais odontológicos |
| WO2018175715A1 (en) | 2017-03-24 | 2018-09-27 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Herpes simplex virus type-1(hsv-1) vaccine strain vc2 generating an anti-ehv-1 immune response |
| US12251700B2 (en) | 2017-10-25 | 2025-03-18 | Stratec Se | Thermal cycler |
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| US3053454A (en) * | 1959-04-13 | 1962-09-11 | Buensod Stacey Corp | Fluid mixer and flow regulator |
| US3030024A (en) * | 1960-03-14 | 1962-04-17 | Honeywell Regulator Co | Double duct air conditioning apparatus |
| FR1585392A (es) * | 1968-11-15 | 1970-01-16 | ||
| GB1323309A (en) * | 1969-12-24 | 1973-07-11 | Toyo Kagaku Sangyo Kk Nobe A | Apparatus for establishing temperature gradients in specimen containers |
| US4963499A (en) * | 1983-07-25 | 1990-10-16 | American Cyanamid Company | Method for the calorimetry of chemical processes |
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| EP0175882A1 (de) * | 1984-09-07 | 1986-04-02 | Contraves Ag | Temperiervorrichtung zu einem Laborreaktor |
| US5038852A (en) * | 1986-02-25 | 1991-08-13 | Cetus Corporation | Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps |
| US4706736A (en) * | 1986-05-20 | 1987-11-17 | Technicon Instruments Corporation | Multi-zone heater arrangement for controlling the temperature of a flowing medium |
| AT387234B (de) * | 1987-03-05 | 1988-12-27 | Vogelbusch Gmbh | Vorrichtung zur zuechtung von dauerformen insbesondere filamentoeser mikroorganismen |
| US5028541A (en) * | 1987-06-01 | 1991-07-02 | The United States Of America As Represented By The Secretary Of The Air Force | Flow-through cell cultivation system |
| DE3808942A1 (de) * | 1988-03-17 | 1989-09-28 | Bio Med Gmbh Ges Fuer Biotechn | Inkubator, insbes. fuer die polymerase-ketten-methode |
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| US5133936A (en) * | 1988-09-07 | 1992-07-28 | Hitachi, Ltd. | Constant-temperature air type automatic analysis apparatus |
| US4865986A (en) * | 1988-10-06 | 1989-09-12 | Coy Corporation | Temperature control apparatus |
| DE8814398U1 (de) * | 1988-11-17 | 1989-02-16 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV, 3400 Göttingen | Thermostatiergerät |
| DE3839162A1 (de) * | 1988-11-19 | 1990-05-23 | Arman Notghi | Vorrichtung zur selbsttaetigen einstellung von vielfaeltigen temperaturzustaenden bei molekularbiologischen verfahren |
| US5123477A (en) * | 1989-05-02 | 1992-06-23 | Unisys Corporation | Thermal reactor for biotechnological processes |
| GB8917963D0 (en) * | 1989-08-05 | 1989-09-20 | Scras | Apparatus for repeated automatic execution of a thermal cycle for treatment of biological samples |
| US5455175A (en) * | 1990-06-04 | 1995-10-03 | University Of Utah Research Foundation | Rapid thermal cycling device |
| US5187084A (en) * | 1990-06-22 | 1993-02-16 | The Dow Chemical Company | Automatic air temperature cycler and method of use in polymerose chain reaction |
| DE4028891A1 (de) * | 1990-09-12 | 1992-03-19 | Liebisch Geb | Einrichtung zur behandlung von proben mit vorgegebenen temperatur-zeit-profilen |
| JP3070134B2 (ja) * | 1991-04-26 | 2000-07-24 | 株式会社島津製作所 | インキュベーション装置 |
-
1995
- 1995-01-11 ES ES95906818T patent/ES2120174T3/es not_active Expired - Lifetime
- 1995-01-11 JP JP7518693A patent/JPH09508224A/ja not_active Ceased
- 1995-01-11 AU AU15270/95A patent/AU1527095A/en not_active Abandoned
- 1995-01-11 DE DE69504031T patent/DE69504031T2/de not_active Expired - Fee Related
- 1995-01-11 CA CA002178644A patent/CA2178644A1/en not_active Abandoned
- 1995-01-11 EP EP95906818A patent/EP0739241B1/en not_active Expired - Lifetime
- 1995-01-11 WO PCT/US1995/000413 patent/WO1995018676A1/en not_active Ceased
- 1995-01-11 AT AT95906818T patent/ATE169521T1/de not_active IP Right Cessation
- 1995-04-14 US US08/422,688 patent/US5576218A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09508224A (ja) | 1997-08-19 |
| DE69504031D1 (de) | 1998-09-17 |
| AU1527095A (en) | 1995-08-01 |
| US5576218A (en) | 1996-11-19 |
| CA2178644A1 (en) | 1995-07-13 |
| EP0739241B1 (en) | 1998-08-12 |
| ATE169521T1 (de) | 1998-08-15 |
| WO1995018676A1 (en) | 1995-07-13 |
| DE69504031T2 (de) | 1999-03-18 |
| EP0739241A1 (en) | 1996-10-30 |
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