ES2123122T3 - Derivados de tetrahidrocarbazol como agonistas similares a 5-ht1. - Google Patents
Derivados de tetrahidrocarbazol como agonistas similares a 5-ht1.Info
- Publication number
- ES2123122T3 ES2123122T3 ES94903846T ES94903846T ES2123122T3 ES 2123122 T3 ES2123122 T3 ES 2123122T3 ES 94903846 T ES94903846 T ES 94903846T ES 94903846 T ES94903846 T ES 94903846T ES 2123122 T3 ES2123122 T3 ES 2123122T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- tetrahydrocarbazol
- derivatives
- alkilo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XKLNOVWDVMWTOB-UHFFFAOYSA-N 2,3,4,9-tetrahydro-1h-carbazole Chemical class N1C2=CC=CC=C2C2=C1CCCC2 XKLNOVWDVMWTOB-UHFFFAOYSA-N 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical group C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical group C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 abstract 1
- WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Chemical group O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 abstract 1
- 229940075559 piperine Drugs 0.000 abstract 1
- 235000019100 piperine Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
COMPUESTOS DE FORMULA (I), DONDE R1 REPRESENTA HALOGENO, ALKILO C1-4, ALCOXIC1-4, HIDROXI, NO2, -NR4R5, R4R5NCO(CH2)M, R4R5NSO(CH2)M-, R6CONH(CH2)-M, R7SO2NH(CH2)M-; R4 Y R5 CADA UNO INDEPENDIENTEMENTE SON HIDROGENO O ALKILO C1-4 O NR4R5 REPRESENTA UN ANILLO DE 5 A 7 MIEMBROS; R6 REPRESENTA HIDROGENO O ALKILO C1-4; R7 REPRESENTA ALKILO C1-4; M ES CERO, 1 O 2; N ES CERO O 1 A 5; R2 Y R3 CADA UNO INDEPENDIENTEMENTE REPRESENTAN HIDROGENO, ALKILO C1-5 O BENZILO O -NR2R3 REPRESENTA UN ANILLO PIRROLIDINO, PIPERINO O HEXAHIDROAZEPINO; Y A REPRESENTA UN ENLACE, UNA CADENA ALKILENO C1-5 O UNA CADENA ALKENILO C3-5 DONDE EL ENLACE DOBLE NO ES ADYACENTE DEL ATOMO DE NITROGENO; Y SUS SALES TIENEN AFINIDAD PARA EL RECEPTOR 5-HT1-LIKE Y SON UTILES POR EJEMPLO EN EL TRATAMIENTO DE LA MIGRAÑA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929226566A GB9226566D0 (en) | 1992-12-21 | 1992-12-21 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2123122T3 true ES2123122T3 (es) | 1999-01-01 |
Family
ID=10726934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94903846T Expired - Lifetime ES2123122T3 (es) | 1992-12-21 | 1993-12-16 | Derivados de tetrahidrocarbazol como agonistas similares a 5-ht1. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5612331A (es) |
| EP (1) | EP0674622B1 (es) |
| JP (1) | JPH08504791A (es) |
| DE (1) | DE69320653T2 (es) |
| ES (1) | ES2123122T3 (es) |
| GB (1) | GB9226566D0 (es) |
| WO (1) | WO1994014773A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5892041A (en) * | 1996-08-12 | 1999-04-06 | Neurogen Corporation | Fused indolecarboxamides: dopamine receptor subtype specific ligands |
| US6221884B1 (en) | 1997-06-04 | 2001-04-24 | Eli Lilly And Company | Carboxamides useful as 5-HT1F agonists |
| ID23053A (id) * | 1997-06-04 | 2000-01-20 | Lilly Co Eli | Karboksamida yang digunakan sebagai agonis 5-ht <if> |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| US6262124B1 (en) * | 1998-10-22 | 2001-07-17 | Gary Maurice Dull | Pharmaceutical compositions and methods for use |
| AU3840000A (en) | 1999-04-20 | 2000-11-02 | Meiji Seika Kaisha Ltd. | Tricyclic compounds |
| AU2006214233A1 (en) * | 2005-02-17 | 2006-08-24 | Wyeth | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
| US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
| CN109206360B (zh) * | 2017-07-01 | 2022-05-17 | 复旦大学 | 咔唑酰胺类衍生物或其盐及其制备方法和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4257952A (en) * | 1977-06-06 | 1981-03-24 | Sterling Drug Inc. | 3-Amino-tetrahydrocarbazoles |
| ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
| GB8614287D0 (en) * | 1986-06-12 | 1986-07-16 | Glaxo Group Ltd | Chemical compounds |
| GB9113802D0 (en) * | 1991-06-26 | 1991-08-14 | Smithkline Beecham Plc | Medicaments |
-
1992
- 1992-12-21 GB GB929226566A patent/GB9226566D0/en active Pending
-
1993
- 1993-12-16 DE DE69320653T patent/DE69320653T2/de not_active Expired - Fee Related
- 1993-12-16 JP JP6514807A patent/JPH08504791A/ja active Pending
- 1993-12-16 WO PCT/EP1993/003628 patent/WO1994014773A1/en not_active Ceased
- 1993-12-16 EP EP94903846A patent/EP0674622B1/en not_active Expired - Lifetime
- 1993-12-16 ES ES94903846T patent/ES2123122T3/es not_active Expired - Lifetime
- 1993-12-16 US US08/464,615 patent/US5612331A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0674622A1 (en) | 1995-10-04 |
| DE69320653T2 (de) | 1999-03-25 |
| EP0674622B1 (en) | 1998-08-26 |
| DE69320653D1 (de) | 1998-10-01 |
| JPH08504791A (ja) | 1996-05-21 |
| WO1994014773A1 (en) | 1994-07-07 |
| US5612331A (en) | 1997-03-18 |
| GB9226566D0 (en) | 1993-02-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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