ES2125446T3 - Procedimiento para precipitar avermectinas naturales y fermentacion de las mismas. - Google Patents

Procedimiento para precipitar avermectinas naturales y fermentacion de las mismas.

Info

Publication number
ES2125446T3
ES2125446T3 ES94912049T ES94912049T ES2125446T3 ES 2125446 T3 ES2125446 T3 ES 2125446T3 ES 94912049 T ES94912049 T ES 94912049T ES 94912049 T ES94912049 T ES 94912049T ES 2125446 T3 ES2125446 T3 ES 2125446T3
Authority
ES
Spain
Prior art keywords
water
natural
fermentation
precipitation
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94912049T
Other languages
English (en)
Inventor
Abdullah R Ali
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2125446T3 publication Critical patent/ES2125446T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

UN PROCESO PARA SEPARAR UNA AVERMECTINA B NATURAL DE UNA AVERMECTINA NATURAL QUE CONTIENE CALDO DE FERMENTACION MEDIANTE LA UTILIZACION DE UNA PRECIPITACION ACUOSA. EL PROCESO COMPRENDE LA EXTRACCION DE AVERMECTINAS NATURALES DEL CALDO DE FERMENTACION CON UN DISOLVENTE MEZCLABLE EN AGUA Y LA ADICION DE SUFICIENTE AGUA PARA PRECIPITAR LAS AVERMECTINAS NATURALES B. PREFERIBLEMENTE, EL DISOLVENTE MEZCLABLE EN AGUA ES UN ALCOHOL C{SUB, 1}-C{SUB, 3}, ACETONA, O ACETONITRILO. ADEMAS, PUEDE AÑADIRSE UN ACIDO, BASE, SAL O SURFACTANTE PARA FACILITAR LA PRECIPITACION. ESTA INVENCION PROPORCIONA UNA TECNICA DE AISLAMIENTO QUE SUSTITUYE EL USO DE UNA PRECIPITACION ACUOSA PARA PRECIPITACIONES DE DISOLVENTES NO ACUOSOS. LA REDUCCION EN EL USO DE DISOLVENTES NO ACUOSOS PROPORCIONAR BENEFICIOS ECONOMICOS, AMBIENTALES Y DE SEGURIDAD.
ES94912049T 1993-07-23 1994-04-26 Procedimiento para precipitar avermectinas naturales y fermentacion de las mismas. Expired - Lifetime ES2125446T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9674593A 1993-07-23 1993-07-23

Publications (1)

Publication Number Publication Date
ES2125446T3 true ES2125446T3 (es) 1999-03-01

Family

ID=22258886

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94912049T Expired - Lifetime ES2125446T3 (es) 1993-07-23 1994-04-26 Procedimiento para precipitar avermectinas naturales y fermentacion de las mismas.

Country Status (16)

Country Link
US (2) US5686274A (es)
EP (1) EP0710290B1 (es)
JP (1) JP2828343B2 (es)
AT (1) ATE175240T1 (es)
AU (1) AU674743B2 (es)
BR (1) BR9407141A (es)
CA (1) CA2167186C (es)
CO (1) CO4230201A1 (es)
DE (1) DE69415675T2 (es)
DK (1) DK0710290T3 (es)
ES (1) ES2125446T3 (es)
FI (2) FI112092B (es)
GR (1) GR3029285T3 (es)
NZ (1) NZ263615A (es)
WO (1) WO1995003419A1 (es)
ZA (1) ZA945415B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4139797A (en) * 1997-06-09 1998-12-30 Nauchno-Proizvodstvennoye Obiedinenie "Farmbiomed" (streptomyces avermitilis) strain, method for separating avermectin complexe s and preparations for protecting plants and animals
KR100419554B1 (ko) * 1999-10-29 2004-02-19 주식회사유한양행 아버멕틴의 정제방법
US6872708B2 (en) * 2001-09-10 2005-03-29 Mitsukazu Matsumoto Local injection prescription
JP4373080B2 (ja) * 2002-12-24 2009-11-25 三井化学アグロ株式会社 ミルベマイシン類の精製法
AU2004325859A1 (en) * 2004-12-23 2006-06-29 J P Laboratories Pvt. Ltd. Process for preparing a detergent
CN103333214B (zh) * 2013-07-03 2015-08-12 大庆志飞生物化工有限公司 一种阿维菌素B2a精粉的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI56187C (fi) * 1970-07-02 1979-12-10 Takeda Chemical Industries Ltd Foerfarande foer framstaellning av antibiotiskt aktiva estrar av makrolidglykosiderna b-5050 eller tetrahydro b-5050
US4017516A (en) * 1972-11-15 1977-04-12 Schering Corporation Novel monoesters of rosamicin
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4201861A (en) * 1977-10-03 1980-05-06 Merck & Co., Inc. Acyl derivatives of C-076 compounds
US4307085A (en) * 1979-11-09 1981-12-22 Schering Corporation Antibiotic AR-5 complex, antibiotics coproduced therewith and derivatives thereof
US4389397A (en) * 1980-08-04 1983-06-21 Merck & Co., Inc. Solubilization of ivermectin in water
US4399274A (en) * 1981-07-02 1983-08-16 Merck & Co., Inc. Isolation of non-ionic lipophilic materials on macroreticular polymeric absorbents
US4703009A (en) * 1983-03-08 1987-10-27 Merck & Co., Inc. RDNA cloning vector pVE1, deletion and hybrid mutants and recombinant derivatives thereof products and processes
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
US5077348A (en) * 1986-10-31 1991-12-31 Toyo Ink Manufacturing Co., Ltd. Aqueous coating composition, process for the production thereof and aqueous coating
US5077398A (en) * 1986-11-18 1991-12-31 Merck & Co., Inc. Process for isolation of avermectin B1 components with improved purity and subsequent isolaton of B2 components
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法

Also Published As

Publication number Publication date
JPH08506966A (ja) 1996-07-30
FI112092B (fi) 2003-10-31
US5686274A (en) 1997-11-11
FI20030488L (fi) 2003-04-01
AU6436194A (en) 1995-02-20
EP0710290B1 (en) 1998-12-30
FI960304L (fi) 1996-01-22
GR3029285T3 (en) 1999-05-28
NZ263615A (en) 1997-08-22
ZA945415B (en) 1996-01-22
CO4230201A1 (es) 1995-10-19
DE69415675T2 (de) 1999-05-20
DK0710290T3 (da) 1999-08-30
EP0710290A1 (en) 1996-05-08
CA2167186A1 (en) 1995-02-02
DE69415675D1 (de) 1999-02-11
FI112375B (fi) 2003-11-28
WO1995003419A1 (en) 1995-02-02
ATE175240T1 (de) 1999-01-15
US5905034A (en) 1999-05-18
CA2167186C (en) 1999-01-26
JP2828343B2 (ja) 1998-11-25
BR9407141A (pt) 1996-09-17
AU674743B2 (en) 1997-01-09
FI960304A0 (fi) 1996-01-22

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