ES2125973T3 - Mezcla de alcoholes alifaticos primarios superiores y sus usos farmaceuticos. - Google Patents

Mezcla de alcoholes alifaticos primarios superiores y sus usos farmaceuticos.

Info

Publication number
ES2125973T3
ES2125973T3 ES93903874T ES93903874T ES2125973T3 ES 2125973 T3 ES2125973 T3 ES 2125973T3 ES 93903874 T ES93903874 T ES 93903874T ES 93903874 T ES93903874 T ES 93903874T ES 2125973 T3 ES2125973 T3 ES 2125973T3
Authority
ES
Spain
Prior art keywords
mixture
aliphatic alcohols
primary aliphatic
pharmaceutical uses
higher primary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93903874T
Other languages
English (en)
Inventor
Granja Abilio Laguna
Hernandez Juan Magraner
Quintana Carbajal
Valmana Lourdes Arruzazabala
Ferreiro Rosa Mas
Mesa Milagros Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Dalmer SA
Original Assignee
Laboratorios Dalmer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Dalmer SA filed Critical Laboratorios Dalmer SA
Application granted granted Critical
Publication of ES2125973T3 publication Critical patent/ES2125973T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/88—Separation; Purification; Use of additives, e.g. for stabilisation by treatment giving rise to a chemical modification of at least one compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/02—Monohydroxylic acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/02—Monohydroxylic acyclic alcohols
    • C07C31/125—Monohydroxylic acyclic alcohols containing five to twenty-two carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Fats And Perfumes (AREA)
  • Indole Compounds (AREA)

Abstract

UNA MEZCLA DE ALCOHOLES ALIFATICOS PRIMARIOS SUPERIORES DE 22 A 38 ATOMOS DE CARBONO PUEDEN SER OBTENIDOS POR PASOS DE SAPONIFICACION Y EXTRACCION CON DISOLVENTES ORGANICOS A PARTIR DE CERA DE CAÑA DE AZUCAR. LA MEZCLA QUE CONTIENE TETRACOSANOL, HEXACOSANOL, HEPTACOSANOL, OCTACOSANOL, NONACOSANOL, TRIACONTANOL Y TETRATRIOCONTANOL PUEDE SER USADA PARA EL TRATAMIENTO DE HIPERCOLESTEROLEMIA, Y COMPLICACIONES ATEROESCLEROTICAS COMO AGREGABILIDAD TROMBOCITICA, ISQUEMIA Y TROMBOSIS, Y EVITA LA ULCERA GASTRICA INDUCIDA POR DROGA Y MEJORA LA ACTIVIDAD SEXUAL MASCULINA.
ES93903874T 1992-09-29 1993-02-25 Mezcla de alcoholes alifaticos primarios superiores y sus usos farmaceuticos. Expired - Lifetime ES2125973T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU92107A CU22229A1 (es) 1992-09-29 1992-09-29 Policosanol, una mezcla de alcoholes alifaticos primarios superiores para hipergregabilidad plaquetaria, los accidentes isquemicos, trombosis e incluso efectividad contra ulceras gastricas quimicamente inducidas y su proceso de obtencion de la caña de azucar. el tratamiento de complicaciones ateroscleroticas tales como la

Publications (1)

Publication Number Publication Date
ES2125973T3 true ES2125973T3 (es) 1999-03-16

Family

ID=5459372

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93903874T Expired - Lifetime ES2125973T3 (es) 1992-09-29 1993-02-25 Mezcla de alcoholes alifaticos primarios superiores y sus usos farmaceuticos.

Country Status (18)

Country Link
US (2) US5663156A (es)
EP (1) EP0619802B1 (es)
JP (1) JP3602531B2 (es)
KR (1) KR100269844B1 (es)
CN (3) CN1736384B (es)
AT (1) ATE172954T1 (es)
AU (2) AU682462B2 (es)
BR (1) BR9305652A (es)
CA (1) CA2124578C (es)
CU (1) CU22229A1 (es)
DE (1) DE69321941T2 (es)
DK (1) DK0619802T3 (es)
EG (1) EG20174A (es)
ES (1) ES2125973T3 (es)
GR (1) GR3029280T3 (es)
HU (2) HU225050B1 (es)
RU (1) RU2163229C2 (es)
WO (1) WO1994007830A1 (es)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
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CU22229A1 (es) * 1992-09-29 1996-01-31 Dalmer Lab Sa Policosanol, una mezcla de alcoholes alifaticos primarios superiores para hipergregabilidad plaquetaria, los accidentes isquemicos, trombosis e incluso efectividad contra ulceras gastricas quimicamente inducidas y su proceso de obtencion de la caña de azucar. el tratamiento de complicaciones ateroscleroticas tales como la
CU22412A1 (es) * 1993-11-09 1996-01-31 Dalmer Lab Sa Una mezcla natural compuesta por alcoholes alifaticos primarios superiores obtenidos de la cera de abejas para el tratamiento de las ulceras gastricas y duodenales que presenta tambien actividad antiinflamatoria
CU22723A1 (es) * 1997-04-02 2002-02-28 Dalmer Lab Sa Mezcla de ácidos grasos primarios de alto peso molecular obtenidos de la cera de cana de azúcar y sus usos farmacéuticos
IT1294227B1 (it) * 1997-08-01 1999-03-24 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o una alcanoil l-carnitina e alcoli alifatici a lunga catena utile per la prevenzione
US5952393A (en) * 1998-02-12 1999-09-14 Sorkin, Jr.; Harlan Lee Composition for reducing serum cholesterol levels
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US6225354B1 (en) 1999-06-21 2001-05-01 Cholesterol Control Laboratories, Inc. High molecular weight primary aliphatic alcohols obtained from beeswax and pharmaceutical use thereof
US6596776B2 (en) 1999-06-21 2003-07-22 Hauser, Inc. High molecular weight primary aliphatic alcohols obtained from natural products and uses thereof
US6197832B1 (en) 1999-09-14 2001-03-06 Harlan Lee Sorkin, Jr. Composition for reducing serum cholesterol levels
US7232574B1 (en) 1999-12-15 2007-06-19 Mcneil-Ppc, Inc. Long chain alcohols provided in edible oils
US6355274B1 (en) * 1999-12-15 2002-03-12 Mcneil-Ppc, Inc. Encapsulated long chain alcohols
CN1091093C (zh) * 1999-12-30 2002-09-18 广东省食品工业研究所 高级脂肪醇脂肪酸酯及其用途
CN1100744C (zh) * 2000-04-30 2003-02-05 雷少华 一种由蔗蜡制取高级脂肪伯醇混合物的方法
US20030054978A1 (en) * 2001-08-31 2003-03-20 Babish John G. Arginine compositions for coordinate modification of multiple cardiovascular risk factors
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EP1503632A1 (en) * 2002-05-02 2005-02-09 Volker Kuellmer Coated, agglomerated phytochemicals
US7214394B2 (en) * 2002-05-31 2007-05-08 Archer-Daniels-Midland Company Policosanol compositions, extraction from novel sources, and uses thereof
US20060166951A1 (en) * 2002-05-31 2006-07-27 Archer-Daniels-Midland Company Compositions and methods for sterol isolation and purification
JP4533134B2 (ja) * 2002-06-10 2010-09-01 エラン ファーマ インターナショナル，リミティド ナノ粒子ポリコサノール製剤および新規なポリコサノールの組合せ
RU2331415C2 (ru) * 2002-06-17 2008-08-20 Медести Ресерч Энд Продакшн С.Р.Л. Длинноцепочечные ненасыщенные оксигенированные соединения и их применение в области терапии, косметики и питания
KR100590620B1 (ko) * 2002-09-13 2006-06-19 박유석 화분으로부터 고급알콜을 제조하는 방법
US20060127449A1 (en) * 2003-01-28 2006-06-15 Hargrove James L Method and composition for lowering cholesterol
US7034060B2 (en) 2003-01-31 2006-04-25 Unigen Pharmaceuticals, Inc. Polycosanols from Ericerus pela wax
US7217546B1 (en) * 2003-07-01 2007-05-15 Sami Labs Ltd Commercially viable process for high purity of fatty alcohol C24 to C36 and its cosmetic application for skin hair and nails
US20050074443A1 (en) * 2003-10-03 2005-04-07 Treadwell Benjamin V. Methods of attenuating autoimmune disease and compositions useful therefor
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CN102795960B (zh) * 2012-08-08 2015-04-22 湖州圣涛生物技术有限公司 一种高纯度二十八烷醇、三十烷醇的规模化制备方法
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CN107332573B (zh) * 2017-07-25 2021-04-13 Oppo广东移动通信有限公司 一种射频电路、天线装置及电子设备
CN110108815B (zh) * 2019-05-24 2022-01-04 江西省科学院生物资源研究所 一种用于二十八烷醇预防肝损伤效果的体外评价方法
CU24638B1 (es) * 2020-02-03 2023-01-16 Centro Nac De Investigaciones Cientificas Suspensión oral con efecto antiulceroso y quimioprotector sobre el cáncer de colon
CN112716923B (zh) * 2021-01-13 2023-03-17 河北康泰药业有限公司 一种二十八元醇在制备治疗肺纤维化药物中的应用
CN113057941B (zh) * 2021-03-26 2022-06-17 中国林业科学研究院资源昆虫研究所 一种改善学习记忆的高级烷醇脂质体及其制备方法
CU24732B1 (es) * 2021-07-13 2025-02-07 Centro Nac De Investigaciones Cientificas Mezcla de compuestos con altos pesos moleculares, obtenida a partir de la cera de caña de azúcar (saccharum officinarum l.)
IT202100020228A1 (it) 2021-07-29 2023-01-29 Chromaleont Srl Metodo per l’estrazione di policosanoli da canapa industriale e relativa miscela.
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Also Published As

Publication number Publication date
AU682462B2 (en) 1997-10-09
CA2124578A1 (en) 1994-04-14
HUT67607A (en) 1995-04-28
HK1087935A1 (en) 2006-10-27
RU2163229C2 (ru) 2001-02-20
BR9305652A (pt) 1996-11-19
AU711756B2 (en) 1999-10-21
HU225050B1 (en) 2006-05-29
CN1201731C (zh) 2005-05-18
DK0619802T3 (da) 1999-07-19
EP0619802B1 (en) 1998-11-04
AU5109298A (en) 1998-03-26
CA2124578C (en) 2003-12-16
US5663156A (en) 1997-09-02
DE69321941T2 (de) 1999-06-10
HU9401938D0 (en) 1994-09-28
AU3493993A (en) 1994-04-26
GR3029280T3 (en) 1999-05-28
CN1271577A (zh) 2000-11-01
HU0300408D0 (en) 2003-04-28
ATE172954T1 (de) 1998-11-15
CU22229A1 (es) 1996-01-31
DE69321941D1 (de) 1998-12-10
JP3602531B2 (ja) 2004-12-15
CN1084844A (zh) 1994-04-06
WO1994007830A1 (en) 1994-04-14
KR100269844B1 (ko) 2000-10-16
HK1032356A1 (en) 2001-07-20
CN1736384A (zh) 2006-02-22
EG20174A (en) 1997-08-31
US5856316A (en) 1999-01-05
CN1736384B (zh) 2010-05-26
JPH07505414A (ja) 1995-06-15
EP0619802A1 (en) 1994-10-19

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