ES2127133A1 - Utilizacion de derivados 2,5-dihidroxibencenosulfonicos para la fabricacion de medicamentos destinados al tratamiento y a la prevencion de la enfermedad de alzheimer. - Google Patents

Utilizacion de derivados 2,5-dihidroxibencenosulfonicos para la fabricacion de medicamentos destinados al tratamiento y a la prevencion de la enfermedad de alzheimer.

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Publication number
ES2127133A1
ES2127133A1 ES09700827A ES9700827A ES2127133A1 ES 2127133 A1 ES2127133 A1 ES 2127133A1 ES 09700827 A ES09700827 A ES 09700827A ES 9700827 A ES9700827 A ES 9700827A ES 2127133 A1 ES2127133 A1 ES 2127133A1
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ES
Spain
Prior art keywords
derivatives
manufacture
prevention
treatment
dihydroxybenzenosphone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09700827A
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English (en)
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ES2127133B1 (es
Inventor
Soler Jose Esteve
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2127133A1 publication Critical patent/ES2127133A1/es
Application granted granted Critical
Publication of ES2127133B1 publication Critical patent/ES2127133B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Utilización de derivados 2,5-dihidroxibencenosulfónicos para la fabricación de medicamentos destinados al tratamiento y a la prevención de la enfermedad de Alzheimer. Utilización de derivados 2,5-dihidroxibencenosulfónicos de fórmula general I, en la cual: R representa H o SO{sup,- {sub,3 ; B representa Ca{sup,++ o H{sub,2 N{sup,+ (C{sub,2 H{sub,5 ){sub,2 ; n representa 1 ó 2; y m representa 1 ó 2, para la fabricación de medicamentos destinados a prevenir la formación de la proteína amiloide asociada a la enfermedad de Alzheimer.
ES9700827A 1996-04-03 1997-04-03 Utilizacion de derivados 2,5-dihidroxibencenosulfonicos para la fabricacion de medicamentos destinados al tratamiento y a la prevencion de la enfermedad de alzheimer. Expired - Fee Related ES2127133B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9604181 1996-04-03

Publications (2)

Publication Number Publication Date
ES2127133A1 true ES2127133A1 (es) 1999-04-01
ES2127133B1 ES2127133B1 (es) 1999-12-01

Family

ID=9490864

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9700827A Expired - Fee Related ES2127133B1 (es) 1996-04-03 1997-04-03 Utilizacion de derivados 2,5-dihidroxibencenosulfonicos para la fabricacion de medicamentos destinados al tratamiento y a la prevencion de la enfermedad de alzheimer.

Country Status (1)

Country Link
ES (1) ES2127133B1 (es)

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FRASER et al. Effects of sulfate ions on Alzheimer beta/A4 Peptide Assemblies: Implications for Amyloid Fibril-Proteoglycan Interactions. Journal of Neurochemistry, 1992, Vol. 59, no 4, paginas 1531-1540. *
KISILEVSKY et al. Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease. Nature Medicine, Vol. 1, no 2, Febrero 1995, paginas 143-148, resumen y discusion. *
LEVEUGLE et al. Binding of heparan sulfate glycosaminoglycan to beta-amyloid peptide: inhibition by potentially therapeutic polysulfated compounds. Neuroreport, Vol. 5, no 11, 27 Junio 1994, paginas 1389-1392. *
NARINDRASORASAK et al. High Affinity Interactions between the Alzheimer's beta-amyloid precursor proteins and the basement Membrane form of heparan sulfate proteoglycan. Journal of Biological Chemistry, Vol. 266, no 20, 1991, paginas 12878-12883. *
SNOW et al. Proteoglycans in the Pathogenesis of Alzheimer's Disease and other Amyloidoses. Neurobiology of Aging, Vol. 10, 1989, paginas 481-497. *

Also Published As

Publication number Publication date
ES2127133B1 (es) 1999-12-01

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