ES2128265A1 - Kit genetico para la caracterizacion molecular de la enfermedad de alzheimer. - Google Patents
Kit genetico para la caracterizacion molecular de la enfermedad de alzheimer.Info
- Publication number
- ES2128265A1 ES2128265A1 ES09701227A ES9701227A ES2128265A1 ES 2128265 A1 ES2128265 A1 ES 2128265A1 ES 09701227 A ES09701227 A ES 09701227A ES 9701227 A ES9701227 A ES 9701227A ES 2128265 A1 ES2128265 A1 ES 2128265A1
- Authority
- ES
- Spain
- Prior art keywords
- kit
- alzheimer
- genetic
- disease
- molecular identification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 5
- 230000002068 genetic effect Effects 0.000 title abstract 3
- 238000004458 analytical method Methods 0.000 abstract 2
- 229920000936 Agarose Polymers 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- -1 deoxynucleotides Proteins 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 238000011835 investigation Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Kit genético para la caracterización molecular de la enfermedad de alzheimer. El kit genético ilustrado en la figura comprende un primer kit para purificación de ADN constituido por columnas de filtrado, columnas colectoras y frascos de reactivos; y un segundo kit para análisis genotípico constituido por componentes para la determinación de genotipos relacionados con la Enfermedad de Alzheimer (EA) cada uno de los cuales contiene frascos con oligonucleótidos, desoxinucleótidos, enzimas, sales y tampones, junto con geles de separación de agarosa.Con este kit es posible llevar a cabo un método analítico de muestras de sangre humana que permite la caracterización molecular de la EA, con importantes aplicaciones en el sector de la investigación biomédica.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009701227A ES2128265B1 (es) | 1997-06-04 | 1997-06-04 | Kit genetico para la caracterizacion molecular de la enfermedad de alzheimer. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009701227A ES2128265B1 (es) | 1997-06-04 | 1997-06-04 | Kit genetico para la caracterizacion molecular de la enfermedad de alzheimer. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2128265A1 true ES2128265A1 (es) | 1999-05-01 |
| ES2128265B1 ES2128265B1 (es) | 2000-03-01 |
Family
ID=8299580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES009701227A Expired - Fee Related ES2128265B1 (es) | 1997-06-04 | 1997-06-04 | Kit genetico para la caracterizacion molecular de la enfermedad de alzheimer. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2128265B1 (es) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2182667A1 (es) * | 2000-12-01 | 2003-03-01 | Univ Coruna | Metodo universal de extraccion de adn de alta calidad. |
| ES2188384A1 (es) * | 2001-06-21 | 2003-06-16 | Clinica Perio S L | Procedimiento de obtencion de adn humano a partir de fluido crevicular gingival. |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992013069A1 (en) * | 1991-01-21 | 1992-08-06 | Imperial College Of Science, Technology & Medicine | Test and model for alzheimer's disease |
| WO1995016791A1 (en) * | 1993-12-15 | 1995-06-22 | Mcgill University | Apolipoprotein e polymorphism and alzheimer's disease |
| US5449604A (en) * | 1992-10-21 | 1995-09-12 | University Of Washington | Chromosome 14 and familial Alzheimers disease genetic markers and assays |
| WO1995024504A1 (fr) * | 1994-03-07 | 1995-09-14 | Institut Pasteur | Marqueurs genetiques utilises conjointement pour le diagnostic de la maladie d'alzheimer, methode et kit de diagnostic |
| WO1996034099A2 (en) * | 1995-04-28 | 1996-10-31 | Hsc Research And Development Limited Partnership | Genetic sequences and proteins related to alzheimer's disease, and uses therefor |
| WO1997003192A2 (en) * | 1995-07-07 | 1997-01-30 | Darwin Molecular Corporation | Chromosome 1 gene and gene products related to alzheimer's disease |
| WO1997015689A1 (en) * | 1995-10-25 | 1997-05-01 | Washington University School Of Medicine | Method to detect polymorphism in the s182 gene |
-
1997
- 1997-06-04 ES ES009701227A patent/ES2128265B1/es not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992013069A1 (en) * | 1991-01-21 | 1992-08-06 | Imperial College Of Science, Technology & Medicine | Test and model for alzheimer's disease |
| US5449604A (en) * | 1992-10-21 | 1995-09-12 | University Of Washington | Chromosome 14 and familial Alzheimers disease genetic markers and assays |
| WO1995016791A1 (en) * | 1993-12-15 | 1995-06-22 | Mcgill University | Apolipoprotein e polymorphism and alzheimer's disease |
| WO1995024504A1 (fr) * | 1994-03-07 | 1995-09-14 | Institut Pasteur | Marqueurs genetiques utilises conjointement pour le diagnostic de la maladie d'alzheimer, methode et kit de diagnostic |
| WO1996034099A2 (en) * | 1995-04-28 | 1996-10-31 | Hsc Research And Development Limited Partnership | Genetic sequences and proteins related to alzheimer's disease, and uses therefor |
| WO1997003192A2 (en) * | 1995-07-07 | 1997-01-30 | Darwin Molecular Corporation | Chromosome 1 gene and gene products related to alzheimer's disease |
| WO1997015689A1 (en) * | 1995-10-25 | 1997-05-01 | Washington University School Of Medicine | Method to detect polymorphism in the s182 gene |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2182667A1 (es) * | 2000-12-01 | 2003-03-01 | Univ Coruna | Metodo universal de extraccion de adn de alta calidad. |
| ES2182667B1 (es) * | 2000-12-01 | 2004-06-01 | Universidade Da Coruña | Metodo universal de extraccion de adn de alta calidad. |
| ES2188384A1 (es) * | 2001-06-21 | 2003-06-16 | Clinica Perio S L | Procedimiento de obtencion de adn humano a partir de fluido crevicular gingival. |
| ES2188384B1 (es) * | 2001-06-21 | 2005-01-01 | Clinica Perio, S.L. | Procedimiento de obtencion de adn humano a partir de fluido crevicular gingival. |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2128265B1 (es) | 2000-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19990501 Kind code of ref document: A1 Effective date: 19990501 |
|
| PC2A | Transfer of patent | ||
| GC2A | Exploitation certificate registered application with search report |
Effective date: 20010418 |
|
| FD2A | Announcement of lapse in spain |
Effective date: 20180807 |