ES2128411T3 - Inhalador de polvo con soportes de polvo con microestructuras regulares. - Google Patents
Inhalador de polvo con soportes de polvo con microestructuras regulares.Info
- Publication number
- ES2128411T3 ES2128411T3 ES93900033T ES93900033T ES2128411T3 ES 2128411 T3 ES2128411 T3 ES 2128411T3 ES 93900033 T ES93900033 T ES 93900033T ES 93900033 T ES93900033 T ES 93900033T ES 2128411 T3 ES2128411 T3 ES 2128411T3
- Authority
- ES
- Spain
- Prior art keywords
- powder
- pct
- supports
- inhaler
- regular microstructures
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000843 powder Substances 0.000 title abstract 3
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
- B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
- B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
- B05B11/064—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material the particulate material being stored in several discrete quantities delivered one at a time
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
- B05B11/1091—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
- A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
- A61M2205/073—Syringe, piston type
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA INVENCION SE REFIERE A UN INHALADOR PARA MEDICAMENTOS EN FORMA DE POLVO, DISPONIENDO EL INHALADOR DE SOPORTES (1) PLANOS CON MICROESTRUCTURAS (3) DE SUPERFICIE REGULAR ENTRE LAS CUALES ESTA INCORPORADO EL POLVO DE INHALACION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4142238A DE4142238A1 (de) | 1991-12-20 | 1991-12-20 | Pulverinhalator mit pulvertraeger aus regelmaessigen mikrostrukturen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2128411T3 true ES2128411T3 (es) | 1999-05-16 |
Family
ID=6447656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93900033T Expired - Lifetime ES2128411T3 (es) | 1991-12-20 | 1992-12-11 | Inhalador de polvo con soportes de polvo con microestructuras regulares. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5645050A (es) |
| EP (1) | EP0652784B1 (es) |
| JP (1) | JP3225294B2 (es) |
| AT (1) | ATE177654T1 (es) |
| AU (1) | AU3157793A (es) |
| DE (2) | DE4142238A1 (es) |
| DK (1) | DK0652784T3 (es) |
| ES (1) | ES2128411T3 (es) |
| GR (1) | GR3029719T3 (es) |
| WO (1) | WO1993012831A1 (es) |
| ZA (1) | ZA929919B (es) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6681767B1 (en) * | 1991-07-02 | 2004-01-27 | Nektar Therapeutics | Method and device for delivering aerosolized medicaments |
| WO1993000951A1 (en) * | 1991-07-02 | 1993-01-21 | Inhale, Inc. | Method and device for delivering aerosolized medicaments |
| CA2157584C (en) * | 1993-03-03 | 1999-05-04 | Paul Mulhauser | Dry powder medicament inhalator |
| US5388572A (en) * | 1993-10-26 | 1995-02-14 | Tenax Corporation (A Connecticut Corp.) | Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same |
| US5388573A (en) * | 1993-12-02 | 1995-02-14 | Tenax Corporation | Dry powder inhalator medicament carrier |
| CN1318104C (zh) | 1994-09-21 | 2007-05-30 | 耐科塔医药公司 | 送料管组件 |
| US5647347A (en) * | 1994-10-21 | 1997-07-15 | Glaxo Wellcome Inc. | Medicament carrier for dry powder inhalator |
| US5988163A (en) * | 1995-08-02 | 1999-11-23 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament |
| US5692496A (en) * | 1995-08-02 | 1997-12-02 | Innovative Devices, Llc | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
| US6209538B1 (en) | 1995-08-02 | 2001-04-03 | Robert A. Casper | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
| US5823183A (en) * | 1995-08-02 | 1998-10-20 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
| ES2216418T3 (es) * | 1995-12-07 | 2004-10-16 | Jago Research Ag | Boquilla para un inhalador para la administracion de varias dosis de un polvo seco farmacologico. |
| US7131441B1 (en) | 1995-12-07 | 2006-11-07 | Skyepharma Ag | Inhaler for multiple dosed administration of a pharmacological dry powder |
| CZ298885B6 (cs) * | 1996-02-21 | 2008-03-05 | Schering Corporation | Inhalátor práškových léku |
| US5871010A (en) * | 1996-06-10 | 1999-02-16 | Sarnoff Corporation | Inhaler apparatus with modified surfaces for enhanced release of dry powders |
| US6237590B1 (en) * | 1997-09-18 | 2001-05-29 | Delsys Pharmaceutical Corporation | Dry powder delivery system apparatus |
| US6257233B1 (en) | 1998-06-04 | 2001-07-10 | Inhale Therapeutic Systems | Dry powder dispersing apparatus and methods for their use |
| GB2353222B (en) * | 1999-06-23 | 2001-09-19 | Cambridge Consultants | Inhalers |
| US6948494B1 (en) | 2000-05-10 | 2005-09-27 | Innovative Devices, Llc. | Medicament container with same side airflow inlet and outlet and method of use |
| SE517226C2 (sv) * | 2000-09-25 | 2002-05-14 | Microdrug Ag | Inhalator med luftbroms för torrt pulver |
| US6644309B2 (en) * | 2001-01-12 | 2003-11-11 | Becton, Dickinson And Company | Medicament respiratory delivery device and method |
| SI2143458T1 (sl) * | 2002-03-22 | 2017-09-29 | Clinical Designs Limited | Vpenjalo vsebnika |
| DE10300983A1 (de) * | 2003-01-14 | 2004-07-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Düsensystem für eine Ausbringungsvorrichtung für Flüssigkeiten bestehend aus Düse und Düsenhalter und/oder Überwurfmutter |
| US7621266B2 (en) * | 2003-01-14 | 2009-11-24 | Boehringer Ingelheim International Gmbh | Nozzle-system for a dispenser for fluids consisting of a nozzle and a nozzle-holder and/or screw cap |
| GB0304000D0 (en) * | 2003-02-21 | 2003-03-26 | Clinical Designs Ltd | Dispenser |
| PL1615689T3 (pl) * | 2003-04-09 | 2016-06-30 | Novartis Ag | Urządzenie do aerozolizacji z prowadnicą wyrównującą do przebijania kapsułki |
| GB0323085D0 (en) * | 2003-10-02 | 2003-11-05 | Norton Healthcare Ltd | Dry powder inhalation apparatus |
| SE0303029D0 (sv) | 2003-11-17 | 2003-11-17 | Astrazeneca Ab | Inhaler cap strap |
| GB0327112D0 (en) * | 2003-11-21 | 2003-12-24 | Clincial Designs Ltd | Dispenser and reservoir |
| GB0328859D0 (en) * | 2003-12-12 | 2004-01-14 | Clinical Designs Ltd | Dispenser and counter |
| JP2007517529A (ja) * | 2004-01-09 | 2007-07-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ノズル、ノズル・ホルダ、及び/又はチェック・ナットを備えた液体用供給装置のためのノズル・システム |
| CA2553392A1 (en) | 2004-01-16 | 2005-08-11 | Biodel Inc | Sublingual drug delivery device |
| DE102004012093A1 (de) * | 2004-03-05 | 2005-09-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverinhalator mit Merkanaldüse |
| GB0425518D0 (en) | 2004-11-19 | 2004-12-22 | Clinical Designs Ltd | Substance source |
| GB0428204D0 (en) | 2004-12-23 | 2005-01-26 | Clinical Designs Ltd | Medicament container |
| NZ563417A (en) | 2005-05-18 | 2012-01-12 | Mpex Pharmaceuticals Inc | Aerosolized fluoroquinolones and uses thereof |
| US8524735B2 (en) | 2005-05-18 | 2013-09-03 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| GB0518400D0 (en) | 2005-09-09 | 2005-10-19 | Clinical Designs Ltd | Dispenser |
| JP2008064343A (ja) * | 2006-09-05 | 2008-03-21 | Denso Corp | 熱交換器 |
| GB0623728D0 (en) | 2006-11-28 | 2007-01-10 | Optinose As | Delivery devices |
| US8629139B2 (en) | 2008-10-07 | 2014-01-14 | Mpex Pharmaceuticals, Inc. | Topical use of Levofloxacin for reducing lung inflammation |
| CA2739897C (en) | 2008-10-07 | 2017-10-03 | Mpex Pharmaceuticals, Inc. | Aerosol fluoroquinolone formulations for improved pharmacokinetics |
| GB0904040D0 (en) | 2009-03-10 | 2009-04-22 | Euro Celtique Sa | Counter |
| GB0904059D0 (en) | 2009-03-10 | 2009-04-22 | Euro Celtique Sa | Counter |
| DK2473170T3 (da) | 2009-09-04 | 2019-08-12 | Horizon Orphan Llc | Anvendelse af aerosoliseret levofloxacin til behandling af cystisk fibrose |
| PT105065B (pt) * | 2010-04-26 | 2012-07-31 | Hovione Farmaciencia S A | Um inalador simples de cápsulas |
| ES2913095T3 (es) | 2011-01-31 | 2022-05-31 | Avalyn Pharma Inc | Compuestos de pirfenidona y análogos de piridona en aerosol y usos de los mismos |
| DE102012103000A1 (de) * | 2012-04-05 | 2013-10-10 | Rpc Formatec Gmbh | Spender zur Ausbringung einer insbesondere körnigen oder pulverförmigen Substanz und Verfahren zur Entleerung einer Substanz-Aufnahme |
| JP6799201B2 (ja) | 2013-07-31 | 2020-12-16 | アヴァリン ファーマ インク. | エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用 |
| EP4491180A1 (en) | 2014-01-10 | 2025-01-15 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| US10179215B2 (en) | 2015-03-19 | 2019-01-15 | Altria Client Services Llc | Vaporizer for vaporizing a constituent of a plant material |
| US10765821B2 (en) * | 2015-03-19 | 2020-09-08 | Altria Client Services Llc | Vaporizer for vaporizing a constituent of a plant material |
| USD916361S1 (en) | 2019-06-25 | 2021-04-13 | Altria Client Services Llc | Aerosol-generating capsule |
| US11458262B2 (en) | 2019-06-25 | 2022-10-04 | Altria Client Services Llc | Capsules, heat-not-burn (HNB) aerosol-generating devices, and methods of generating an aerosol |
| US12193502B2 (en) | 2020-12-30 | 2025-01-14 | Altria Client Services Llc | Capsules including embedded corrugated heater, heat-not-burn (HNB) aerosol-generating devices, and methods of generating an aerosol |
| US12053022B2 (en) | 2021-01-04 | 2024-08-06 | Altria Client Services Llc | Capsules with integrated mouthpieces, heat-not-burn (HNB) aerosol-generating devices, and methods of generating an aerosol |
| US12569008B2 (en) | 2021-01-18 | 2026-03-10 | Altria Client Services Llc | Heat-not-burn (HNB) aerosol generating devices and capsules |
| US11910826B2 (en) | 2021-01-18 | 2024-02-27 | Altria Client Services Llc | Heat-not-burn (HNB) aerosol-generating devices and capsules |
| US12274295B2 (en) | 2021-01-18 | 2025-04-15 | Altria Client Services Llc | Heat-not-burn (HNB) aerosol-generating devices and capsules |
| US12011034B2 (en) | 2021-01-18 | 2024-06-18 | Altria Client Services Llc | Capsules including embedded heaters and heat-not-burn (HNB) aerosol-generating devices |
| USD1095794S1 (en) | 2021-01-18 | 2025-09-30 | Altria Client Services Llc | Aerosol-generating capsule |
| US11789476B2 (en) | 2021-01-18 | 2023-10-17 | Altria Client Services Llc | Heat-not-burn (HNB) aerosol-generating devices including intra-draw heater control, and methods of controlling a heater |
| US12520880B2 (en) | 2021-01-18 | 2026-01-13 | Altria Client Services Llc | Heat-not-burn (HNB) aerosol-generating devices including energy based heater control, and methods of controlling a heater |
| US12201148B2 (en) | 2021-01-18 | 2025-01-21 | Altria Client Services Llc | Closed system capsule with airflow, heat-not-burn (HNB) aerosol-generating devices, and methods of generating an aerosol |
| WO2022240897A1 (en) | 2021-05-10 | 2022-11-17 | Sepelo Therapeutics, Llc | Pharmaceutical composition comprising delafloxacin for administration into the lung |
| WO2023028364A1 (en) | 2021-08-27 | 2023-03-02 | Sepelo Therapeutics, Llc | Targeted compositions and uses therof |
| US12127592B2 (en) | 2021-09-20 | 2024-10-29 | Altria Client Services Llc | Capsule validation for heat-not-burn (HNB) aerosol-generating devices |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2816549A (en) * | 1956-11-16 | 1957-12-17 | Isaac E Webster | Dispensing device |
| US3856185A (en) * | 1973-12-26 | 1974-12-24 | Ciba Geigy Corp | Single dose, replaceable supply air pressure operated dispenser |
| US3967761A (en) * | 1974-04-08 | 1976-07-06 | Southwest Research Institute | System for injecting particulate material into the combustion chamber of a repetitive combustion coating apparatus |
| US3998226A (en) * | 1975-09-22 | 1976-12-21 | Edward G. Gomez | Inhalation device for encapsulated concentrates |
| NL192564C (nl) * | 1982-10-08 | 1997-10-03 | Glaxo Group Ltd | Inrichting voor het toedienen van medicamenten aan patiënten. |
| JPS62204756A (ja) * | 1986-03-04 | 1987-09-09 | 大研医工株式会社 | 薬剤揮散方法および装置 |
| US5039561A (en) * | 1986-08-25 | 1991-08-13 | Minnesota Mining And Manufacturing Company | Method for preparing an article having surface layer of uniformly oriented, crystalline, organic microstructures |
| US5204113A (en) * | 1987-04-09 | 1993-04-20 | Fisons Plc | Pharmaceutical compositions containing pentamidine |
| GB8909891D0 (en) * | 1989-04-28 | 1989-06-14 | Riker Laboratories Inc | Device |
| US5192548A (en) * | 1990-04-30 | 1993-03-09 | Riker Laboratoires, Inc. | Device |
| DE4015367A1 (de) * | 1990-05-12 | 1991-11-14 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer mindestens ein medium |
| CA2086123C (en) * | 1990-06-28 | 2002-01-01 | Arun Rajaram Gupte | Apparatus and process for metering powder |
| DE4027390C2 (de) * | 1990-08-30 | 1994-11-03 | Boehringer Ingelheim Kg | Treibgasfreies Inhalationsgerät |
| AU657492B2 (en) * | 1990-09-12 | 1995-03-16 | Hans Bisgaard | An inhaling device |
| US5349947A (en) * | 1993-07-15 | 1994-09-27 | Newhouse Michael T | Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow |
| US5388573A (en) * | 1993-12-02 | 1995-02-14 | Tenax Corporation | Dry powder inhalator medicament carrier |
-
1991
- 1991-12-20 DE DE4142238A patent/DE4142238A1/de not_active Withdrawn
-
1992
- 1992-12-11 AT AT93900033T patent/ATE177654T1/de not_active IP Right Cessation
- 1992-12-11 WO PCT/EP1992/002867 patent/WO1993012831A1/de not_active Ceased
- 1992-12-11 EP EP93900033A patent/EP0652784B1/de not_active Expired - Lifetime
- 1992-12-11 US US08/244,879 patent/US5645050A/en not_active Expired - Lifetime
- 1992-12-11 DE DE59209660T patent/DE59209660D1/de not_active Expired - Fee Related
- 1992-12-11 AU AU31577/93A patent/AU3157793A/en not_active Abandoned
- 1992-12-11 JP JP51138693A patent/JP3225294B2/ja not_active Expired - Fee Related
- 1992-12-11 DK DK93900033T patent/DK0652784T3/da active
- 1992-12-11 ES ES93900033T patent/ES2128411T3/es not_active Expired - Lifetime
- 1992-12-21 ZA ZA929919A patent/ZA929919B/xx unknown
-
1999
- 1999-03-18 GR GR990400789T patent/GR3029719T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP3225294B2 (ja) | 2001-11-05 |
| US5645050A (en) | 1997-07-08 |
| ZA929919B (en) | 1993-06-24 |
| WO1993012831A1 (de) | 1993-07-08 |
| DE4142238A1 (de) | 1993-06-24 |
| EP0652784B1 (de) | 1999-03-17 |
| DK0652784T3 (da) | 1999-09-27 |
| AU3157793A (en) | 1993-07-28 |
| DE59209660D1 (de) | 1999-04-22 |
| JPH07502437A (ja) | 1995-03-16 |
| EP0652784A1 (de) | 1995-05-17 |
| ATE177654T1 (de) | 1999-04-15 |
| GR3029719T3 (en) | 1999-06-30 |
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