ES2128760T3 - Nuevos oxidos de fosfanos, procedimiento para su preparacion asi como medicamentos que contienen estos compuestos. - Google Patents

Nuevos oxidos de fosfanos, procedimiento para su preparacion asi como medicamentos que contienen estos compuestos.

Info

Publication number
ES2128760T3
ES2128760T3 ES95931211T ES95931211T ES2128760T3 ES 2128760 T3 ES2128760 T3 ES 2128760T3 ES 95931211 T ES95931211 T ES 95931211T ES 95931211 T ES95931211 T ES 95931211T ES 2128760 T3 ES2128760 T3 ES 2128760T3
Authority
ES
Spain
Prior art keywords
compounds
pct
phosphanes
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95931211T
Other languages
English (en)
Inventor
Der Saal Wolfgang Von
Herbert Leinert
Karlheinz Stegmeier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6526915&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2128760(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2128760T3 publication Critical patent/ES2128760T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/5304—Acyclic saturated phosphine oxides or thioxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION TRATA DE NUEVOS OXIDOS DE FOSFANO DE FORMULA GENERAL (I), EN LA QUE R{SUP,1} ES UN GRUPO ARILO O HETEROARILO, PUDIENDO ESTAR LOS RADICALES ARILO O HETEROARILO SUSITUIDOS UNA O VARIAS VECES POR NITRO, HALOGENO, NITRILO, HIDROXILO, CARBOXILO, ALCOXICARBONILO, FENILALCOXICARBONILO, FENILO, ALQUILO, TRIFLUORMETILO, ALCOXILO, ALQUENILOXI, ALQUINILOXI, ARALQUILOXI, ALQUILTIO, ALQUILSULFINILO, ALQUILSULFONILO, AMINO, ALQUILAMINO, DIALQUILAMINO, ARALQUILAMINO, DIARALQUIL-AMINO, ALQUILSULFONILAMINO, ALQUILCARBONILAMINO, FORMILAMINO, CARBAMOILO, TIOCARBAMOILO, ALQUILAMINOCARBONILO, DIALQUILAMINOCARBONILO O ALCOXICARBONILALQUILOXI, R{SUP,2} SON IGUALES O DIFERENTES Y SON GRUPOS ALQUILO DE CADENA LINEAL O RAMIFICADA, A ES UN RADICAL ALQUILENO DE CADENA LINEAL O RAMIFICADA, X ES EL GRUPO -CHO UN ATOMO DE NITROGENO, ASI COMO SUS HIDRATOS, SOLVATOS Y SALES FISIOLOGICAMENTE ACEPTABLES. TAMBIEN SON OBJETO DE LA INVENCION LAS FORMAS OPTICAMENTE ACTIVAS, LOS RACEMATOS Y LAS MEZCLAS DIAESTEREOMERICAS DE ESTOS COMPUESTOS, PROCEDIMIENTO PARA SU OBTENCION Y MEDICAMENTOS QUE CONTIENEN ESTOS COMPUESTOS CON EFECTO INHIBIDOR DE LA TROMBINA.
ES95931211T 1994-08-30 1995-08-26 Nuevos oxidos de fosfanos, procedimiento para su preparacion asi como medicamentos que contienen estos compuestos. Expired - Lifetime ES2128760T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4430755A DE4430755A1 (de) 1994-08-30 1994-08-30 Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ES2128760T3 true ES2128760T3 (es) 1999-05-16

Family

ID=6526915

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95931211T Expired - Lifetime ES2128760T3 (es) 1994-08-30 1995-08-26 Nuevos oxidos de fosfanos, procedimiento para su preparacion asi como medicamentos que contienen estos compuestos.

Country Status (11)

Country Link
US (1) US5824679A (es)
EP (1) EP0778839B1 (es)
JP (1) JPH10504832A (es)
AT (1) ATE174922T1 (es)
AU (1) AU3473595A (es)
CA (1) CA2198365A1 (es)
DE (2) DE4430755A1 (es)
DK (1) DK0778839T3 (es)
ES (1) ES2128760T3 (es)
GR (1) GR3029692T3 (es)
WO (1) WO1996006849A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792769A (en) * 1995-09-29 1998-08-11 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
CZ206698A3 (cs) * 1995-12-29 1998-11-11 3- Dimensional Pharmaceuticals, Inc. Amidinové inhibitory proteas
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
AR023510A1 (es) * 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH31294A (en) * 1992-02-13 1998-07-06 Thomae Gmbh Dr K Benzimidazolyl derivatives, pharmaceutical compositions containing these compounds and process for preparing them.
CA2139307A1 (en) * 1992-07-01 1994-01-20 Donald W. Combs 1-arylsulphonyl, arylcarbonyl and 1-arylphosphonyl-3-phenyl-1,4,5,6-tetrahydropyridazines
TW257757B (es) * 1993-03-03 1995-09-21 Boehringer Mannheim Gmbh
DE4306506A1 (de) * 1993-03-03 1994-09-08 Boehringer Mannheim Gmbh Neue 4-Alkylaminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
IL110040A (en) * 1993-06-29 2000-07-16 Nissan Chemical Ind Ltd Pyridazinone derivatives their preparation and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
EP0778839A1 (de) 1997-06-18
US5824679A (en) 1998-10-20
AU3473595A (en) 1996-03-22
WO1996006849A1 (de) 1996-03-07
DK0778839T3 (da) 1999-08-23
JPH10504832A (ja) 1998-05-12
CA2198365A1 (en) 1996-03-07
GR3029692T3 (en) 1999-06-30
EP0778839B1 (de) 1998-12-23
ATE174922T1 (de) 1999-01-15
DE4430755A1 (de) 1996-03-07
DE59504643D1 (de) 1999-02-04

Similar Documents

Publication Publication Date Title
HUT77925A (hu) Dihidrobenzofuránok, azokat tartalmazó gyógyászati készítmények és eljárás előállításukra
ATE231134T1 (de) Verwendung von dioxomorpholinen zur bekämpfung von endoparasiten, neue dioxomorpholine und verfahren zu ihrer herstellung
BR9713465A (pt) Inibidores metalotprotease de amina cìclica sibstituìda
SE8601103D0 (sv) Neue, schwefelhaltige 5-substituierte benzimidazol-derivate und verfahren zu ihrer herstellung
MA23744A1 (fr) Procede pour la preparation de sulfonamides, compositions pharmaceutiques les contenant et leur utilisation
DE59409312D1 (de) Imidazopyridine und ihre anwendung zur behandlung von magen-darm krankheiten
ES2059408T3 (es) Un proceso para la preparacion de un compuesto.
HUT77627A (hu) 2,2-Diklór-alkánkarbonsavak, eljárás előállításukra és ezeket tartalmazó, inzulinrezisztencia kezelésére alkalmazható gyógyszerkészítmények
BR9406362A (pt) Composto,processo para a preparação do mesmo e composição anti-nuclear
ES2186677T3 (es) Derivados de deuteroporfirina sustituidos en las posiciones 3 y 8, agentes farmaceuticos que contienen estos derivados y procedimientos para su preparacion.
HUT35659A (en) Process for producing 4-amino-methylene-chromane- and-chromene-derivatives and pharmaceutical compositions containing them as active agents
DK0874812T3 (da) Hidtil ukendte 2,3,5-trimethyl-4-hydroxyanilidderivater, fremstilling deraf og terapeutisk anvendelse deraf
EA200000431A3 (ru) Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их
ES496038A0 (es) Procedimiento para la obtencion de 2-hidroxialquil-3,4,5- trihidroxi-piperidinas
ES2150461T3 (es) Derivados de amidinofenilalanina, proceso para su preparacion, su empleo y agentes que los contienen como anticoagulantes.
ATE371463T1 (de) Ph-sensitive liposomen und andere typen immunomodulatoren enthaltender gekapselter impfstoffe sowie herstellungs- und anwendungsverfahren dafür
BR9610175A (pt) Composto processo de preparação do composto composição farmacêutica e utilização do composto
DK0778839T3 (da) Nye phosphanoxider, fremgangsmåde til deres fremstilling såvel som lægemidler indeholdende disse forbindelser
DE69619868D1 (de) Piperazinylalkylthiopyrimidin derivate, diese enthaltende pharmazeutische zusammensetzungen und verfahren zu deren herstellung
ES2163001T3 (es) Nuevos derivados de borneol, procedimiento para su preparacion y su utilizacion farmaceutica.
ATE104313T1 (de) Neue 9-g(a)-hydroxy-3-oxo-4,24(25)-stigmastadien26-s|urederivate,verfahren zur herstellung und heilmittel daraus.
FR2737207B1 (fr) Nouvelles n-heterocyclyl-1-aryloxyalcoyl-4-piperidinamines substituees, leur preparation et leur application en therapeutique
ES2137665T3 (es) Nuevos derivados de piridina o piridazina, procedimientos para su preparacion, y medicamentos que contienen estos compuestos.
ES2126923T3 (es) 8-fluoro-antraciclinas, procedimientos para su preparacion y composiciones farmaceuticas que las contienen.
ES2140683T3 (es) Procedimiento para preparar compuestos de benzopirano.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 778839

Country of ref document: ES