ES2129010A1 - Composicion de accion prolongada en granulos que contienen 4-nitro-2- fenoximetansulfonanilida y su procedimiento de preparacion. - Google Patents

Composicion de accion prolongada en granulos que contienen 4-nitro-2- fenoximetansulfonanilida y su procedimiento de preparacion.

Info

Publication number
ES2129010A1
ES2129010A1 ES09702307A ES9702307A ES2129010A1 ES 2129010 A1 ES2129010 A1 ES 2129010A1 ES 09702307 A ES09702307 A ES 09702307A ES 9702307 A ES9702307 A ES 9702307A ES 2129010 A1 ES2129010 A1 ES 2129010A1
Authority
ES
Spain
Prior art keywords
granules
active agent
phenoxymethanesulfonanilide
proceeding
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09702307A
Other languages
English (en)
Other versions
ES2129010B1 (es
Inventor
Miguel Rubinstein
Pablo Wexler
Elias Bernardo Gutman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of ES2129010A1 publication Critical patent/ES2129010A1/es
Application granted granted Critical
Publication of ES2129010B1 publication Critical patent/ES2129010B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Composición de acción prolongada en gránulos que contienen 4-nitro-2-fenoximetansulfonanilida y su procedimiento de preparación, estando la composición formulada mediante una asociación de liberación sostenida en gránulos que mantiene la acción terapéutica del 4-nitro-2-fenoximetansulfonanilida y con disminución de las oscilaciones de las concentraciones plasmáticas; según el procedimiento de preparación de dicha composición, el principio activo es micronizado junto a un desintegrante y adherido por medio de unos polímeros ligantes a unos gránulos neutros compuestos de azúcar, formando gránulos de acción rápida, convencional o inmediata, incorporándose una fracción de los gránulos adheridos y recubiertos con el principio activo con unos polímeros que le confieren una acción controlada y prolongada del principio activo y se la asocia o mezcla a los restantes gránulos que contienen el principio activo (gránulos de acción inmediata), para preparar y administrar diferentes dosificaciones.
ES009702307A 1997-01-02 1997-11-06 Composicion de accion prolongada en granulos que contienen 4-nitro-2- fenoximetansulfonanilida y su procedimiento de preparacion. Expired - Lifetime ES2129010B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AR9700002 1997-01-02

Publications (2)

Publication Number Publication Date
ES2129010A1 true ES2129010A1 (es) 1999-05-16
ES2129010B1 ES2129010B1 (es) 2000-01-16

Family

ID=3460992

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009702307A Expired - Lifetime ES2129010B1 (es) 1997-01-02 1997-11-06 Composicion de accion prolongada en granulos que contienen 4-nitro-2- fenoximetansulfonanilida y su procedimiento de preparacion.

Country Status (4)

Country Link
US (1) US6187343B1 (es)
ES (1) ES2129010B1 (es)
IT (1) IT1297032B1 (es)
PT (1) PT102095B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001022791A3 (en) * 1999-09-28 2002-01-31 Panacea Biotec Ltd Controlled release compositions comprising nimesulide

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1258241A1 (en) * 2001-05-16 2002-11-20 BIOPROGRESS S.p.A. Method of increasing the bioavailability of nimesulide
AR029548A1 (es) * 2001-06-29 2003-07-02 Bindecor S A Composicion de liberacion prolongada en forma de granulos multiples que permiten mantener la accion terapeutica de su principio activo, el 4-nitro-2-fenoximetansulfonanilida
AU2006271150A1 (en) * 2005-07-20 2007-01-25 Panacea Biotec Ltd. Novel pharmaceutical modified release dosage form cyclooxygenase enzyme inhibitor

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56122311A (en) * 1980-02-29 1981-09-25 Eisai Co Ltd Lasting theophylline pharmaceutical composition
JPS6144811A (ja) * 1984-08-10 1986-03-04 Ss Pharmaceut Co Ltd 徐放性ジクロフエナクナトリウム製剤
JPS6339814A (ja) * 1986-08-01 1988-02-20 Teisan Seiyaku Kk トラニラストの経口用持続性製剤
JPH01287020A (ja) * 1988-05-13 1989-11-17 Shin Etsu Chem Co Ltd ワックス被覆徐放性製剤
GB2221842A (en) * 1988-08-16 1990-02-21 Ss Pharmaceutical Co Long-acting diclofenac sodium preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622716A (en) * 1987-02-20 1997-04-22 Farmarc Nederland B.V. Process for preparing a retard product containing diltiazem for a single daily administration
ES2124794T3 (es) * 1992-10-09 1999-02-16 Kanegafuchi Chemical Ind Procedimiento para producir granulados finos.
HU210922B (en) * 1993-05-24 1995-09-28 Europharmaceuticals Sa Nimesulide alkali salt cyclodextrin inclusion complexes their preparation and pharmaceutical compositions containing them
BE1008307A3 (fr) * 1994-06-16 1996-04-02 Europharmaceuticals Sa Sel de nimesulide hydrosoluble, solution aqueuse le contenant, sa preparation et son utilisation.
IT1274034B (it) * 1994-07-26 1997-07-14 Applied Pharma Res Composizioni farmaceutiche a base di gomma da masticare e procedimento per la loro preparazione

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56122311A (en) * 1980-02-29 1981-09-25 Eisai Co Ltd Lasting theophylline pharmaceutical composition
JPS6144811A (ja) * 1984-08-10 1986-03-04 Ss Pharmaceut Co Ltd 徐放性ジクロフエナクナトリウム製剤
JPS6339814A (ja) * 1986-08-01 1988-02-20 Teisan Seiyaku Kk トラニラストの経口用持続性製剤
JPH01287020A (ja) * 1988-05-13 1989-11-17 Shin Etsu Chem Co Ltd ワックス被覆徐放性製剤
GB2221842A (en) * 1988-08-16 1990-02-21 Ss Pharmaceutical Co Long-acting diclofenac sodium preparation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BASE DE DATOS WPI en Derwent, semana 8145, Londres Derwent Publications Ltd., AN 81-82493D & JP 56122311 A (EISAI CO LTD) *
BASE DE DATOS WPI en Derwent, semana 8629, Londres Derwent Publications Ltd., AN 86-184977, & JP 61044811 A (SS PHARMACEUTICAL KK) *
BASE DE DATOS WPI en Derwent, semana 9001, Londres Derwent Publications Ltd., AN-90-004023, & JP 1287020 A (SHINETSU CHEM IND CO LTD) *
BASE DE DATOS WPI en Derwent, semana 9283, Londres Derwent Publications Ltd., AN 88-088412, & JP 63039814 A (TEISAN SEIYAKU KK) *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001022791A3 (en) * 1999-09-28 2002-01-31 Panacea Biotec Ltd Controlled release compositions comprising nimesulide
AP1954A (en) * 1999-09-28 2009-02-10 Panacea Biotec Ltd Controlled release compositions comprising nimesulide.
EP1218889B1 (en) * 1999-09-28 2009-12-02 Panacea Biotec Limited Controlled release compositions comprising nimesulide

Also Published As

Publication number Publication date
PT102095B (pt) 2002-04-29
ITMI972893A1 (it) 1999-06-30
ES2129010B1 (es) 2000-01-16
US6187343B1 (en) 2001-02-13
PT102095A (pt) 1998-07-31
IT1297032B1 (it) 1999-08-03

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