ES2129076T3 - Procedimiento para la preparacion de un concentrado de inmunoglobulina g anti-d y composicion farmaceutica que lo contiene. - Google Patents
Procedimiento para la preparacion de un concentrado de inmunoglobulina g anti-d y composicion farmaceutica que lo contiene.Info
- Publication number
- ES2129076T3 ES2129076T3 ES93810912T ES93810912T ES2129076T3 ES 2129076 T3 ES2129076 T3 ES 2129076T3 ES 93810912 T ES93810912 T ES 93810912T ES 93810912 T ES93810912 T ES 93810912T ES 2129076 T3 ES2129076 T3 ES 2129076T3
- Authority
- ES
- Spain
- Prior art keywords
- igg
- absorber
- plasma
- immunoglobulin
- concentrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/34—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE ELABORA UN PREPARADO G DE ANTI - D - INMUNOGLOBULINA A PARTIR DE PLASMA HUMANO CONTENIENDO ANTI.D IGG O UNA FRACCION DE PLASMA CONTENIENDO ANTI - D IGG, DONDE A) UN PLASMA O LA FRACCION DEL PLASMA SE SOMETE A UNA CROMATOGRAFIA DE INTERCAMBIO DE IONES EN UN VALOR PH EN LA ZONA DESDE 3,5 HASTA 6,5, CON UN ABSORBEDOR, QUE MUESTRA GRUPOS CARBOXIMETIL, GRUPOS FUNCIONALES, DONDE EL ANTI - D IGG ESTA LIGADO AL ABSORBEDOR, B) EL ABSORBEDOR SE LAVA CON ANTI - D - IGG LIGADO EN UNA SOLUCION DE LAVADO, Y A CONTINUACION SE ELUYEN EL ANTI - D IGG, Y ADEMAS C) EL ANTI - D IGG ELUIDO SE TRATA CON UN ABSORBEDOR BASICO CON PROPIEDADES DE INTERCAMBIO DE IONES, PARA LA LIGANDURA DE COMPONENTES NO DESEADOS, Y FINALMENTE SE CONCENTRA EN ANTI - D IGG. EL CONCENTRADO ANTI - D NO INFECCIOSO OBTENIDO CON BUEN RENDIMIENTO POSEE UNA ACTIVIDAD ESPECIFICA DEL MAS DE 0,5 % DE ANTI - D IGG POR GRAMO DE IGG COMPLETO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93810912A EP0659767B2 (de) | 1993-12-27 | 1993-12-27 | Verfahren zur Herstellung eines Konzentrates von Anti-D-Immunoglobulin G und pharmazeutische Zusammensetzung, die dieses enthält |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2129076T3 true ES2129076T3 (es) | 1999-06-01 |
| ES2129076T5 ES2129076T5 (es) | 2003-05-16 |
Family
ID=8215103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93810912T Expired - Lifetime ES2129076T5 (es) | 1993-12-27 | 1993-12-27 | Procedimiento para la preparacion de un concentrado de inmunoglobulina g anti-d y composicion farmaceutica que lo contiene. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5593675A (es) |
| EP (1) | EP0659767B2 (es) |
| JP (1) | JP2926463B2 (es) |
| KR (1) | KR100368563B1 (es) |
| AT (1) | ATE175979T1 (es) |
| AU (1) | AU682243B2 (es) |
| CA (1) | CA2138921C (es) |
| CZ (1) | CZ286271B6 (es) |
| DE (1) | DE59309332D1 (es) |
| DK (1) | DK0659767T4 (es) |
| ES (1) | ES2129076T5 (es) |
| FI (1) | FI112168B (es) |
| GR (1) | GR3029817T3 (es) |
| HU (1) | HU216864B (es) |
| NO (1) | NO315331B1 (es) |
| NZ (1) | NZ278057A (es) |
| PL (1) | PL180358B1 (es) |
| SI (1) | SI9420008B (es) |
| TW (1) | TW311884B (es) |
| WO (1) | WO1995018155A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ507557A (en) * | 1998-05-06 | 2003-10-31 | Genentech Inc | Protein purification by ion exchange chromatography |
| DK2270044T3 (en) * | 1998-06-09 | 2015-01-26 | Csl Behring Ag | Liquid immunoglobulin G (IgG) product |
| DE19923027C2 (de) * | 1999-05-19 | 2002-09-19 | Aventis Behring Gmbh | Verfahren zur Inaktivierung von Viren |
| US6475749B1 (en) * | 1999-08-11 | 2002-11-05 | The Regents Of The University Of California | Rh hybrid antibody |
| SE0001128D0 (sv) * | 2000-03-30 | 2000-03-30 | Amersham Pharm Biotech Ab | A method of producing IgG |
| ES2184594B1 (es) | 2001-01-17 | 2004-01-01 | Probitas Pharma Sa | Procedimiento para la produccion de gammaglobulina g humana inactivada de virus. |
| EP1532983A1 (en) * | 2003-11-18 | 2005-05-25 | ZLB Bioplasma AG | Immunoglobulin preparations having increased stability |
| CA2458750C (en) | 2004-02-23 | 2012-02-07 | Bayer Inc. | Isoolefin-diolefin production process and apparatus therefor |
| EP1885755A4 (en) * | 2005-05-05 | 2009-07-29 | Univ Duke | CD19 ANTIBODY THERAPY FOR AUTOIMMUNE DISEASES |
| TWI320788B (en) | 2005-05-25 | 2010-02-21 | Hoffmann La Roche | Method for the purification of antibodies |
| SI2061803T2 (sl) * | 2006-08-28 | 2023-01-31 | Ares Trading S.A. | Postopek za čiščenje proteinov, ki vsebujejo FC |
| WO2008025747A1 (en) * | 2006-08-28 | 2008-03-06 | Ares Trading S.A. | Process for the purification of fc-fusion proteins |
| IT1397061B1 (it) * | 2009-12-28 | 2012-12-28 | Kedrion Spa | Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale. |
| WO2011095543A1 (en) | 2010-02-04 | 2011-08-11 | Csl Behring Ag | Immunoglobulin preparation |
| EP2361636A1 (en) | 2010-02-26 | 2011-08-31 | CSL Behring AG | Immunoglobulin preparation and storage system for an immunoglobulin preparation |
| RU2467783C2 (ru) * | 2010-07-30 | 2012-11-27 | Закрытое акционерное общество "БиоХимМак СТ" | Способ хроматографического выделения иммуноглобулина |
| US20120076779A1 (en) * | 2010-09-17 | 2012-03-29 | Baxter Healthcare S.A. | STABILIZATION OF IMMUNOGLOBULINS AND OTHER PROTEINS THROUGH AQUEOUS FORMULATIONS WITH SODIUM CHLORIDE AT WEAK ACIDIC TO NEUTRAL ph |
| SG11201400233TA (en) * | 2011-08-26 | 2014-08-28 | Baxter Int | Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition |
| AU2013203043B2 (en) * | 2013-03-15 | 2016-10-06 | Takeda Pharmaceutical Company Limited | Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs |
| KR101917196B1 (ko) * | 2014-03-11 | 2018-11-09 | 주식회사 녹십자홀딩스 | 면역글로불린의 정제방법 |
| KR101917197B1 (ko) * | 2014-03-11 | 2018-11-09 | 주식회사 녹십자홀딩스 | 면역글로불린의 정제방법 |
| ES2988823T3 (es) | 2014-12-03 | 2024-11-21 | Csl Behring Ag | Producto farmacéutico con mayor estabilidad que comprende inmunoglobulinas |
| EP3810649A1 (en) * | 2018-06-22 | 2021-04-28 | Genmab A/S | Method for producing a controlled mixture of two or more different antibodies |
| EP4349859A1 (en) * | 2023-01-27 | 2024-04-10 | CSL Behring AG | Method to purify anti-d immunoglobulin g from plasma |
| EP4655316A1 (en) * | 2023-01-27 | 2025-12-03 | CSL Behring AG | Method for reducing protease activity in a solution comprising anti-d immunoglobulin g |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3869436A (en) * | 1971-06-01 | 1975-03-04 | Statens Bakteriologiska Lab | Method for fractionating plasma proteins using peg and ion-exchangers |
| EP0085747B2 (de) * | 1982-02-08 | 1990-05-30 | Schweizerisches Serum- und Impfinstitut und Institut zur Erforschung der Infektionskrankheiten | Intravenös verabreichbares humanes Immunglobulin und Verfahren zu dessen Herstellung |
| US4434093A (en) * | 1982-07-26 | 1984-02-28 | Ortho Diagnostic Systems Inc. | Methods for preparation of HBs Ag free gamma globulins |
| DE3640513A1 (de) * | 1986-11-27 | 1988-06-09 | Biotest Pharma Gmbh | Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates |
| US5118796A (en) * | 1987-12-09 | 1992-06-02 | Centocor, Incorporated | Efficient large-scale purification of immunoglobulins and derivatives |
| US5138034A (en) * | 1989-07-12 | 1992-08-11 | The Green Cross Corporation | Method of fractionating plasma proteins |
| US5177194A (en) * | 1990-02-01 | 1993-01-05 | Baxter International, Inc. | Process for purifying immune serum globulins |
-
1993
- 1993-12-27 DE DE59309332T patent/DE59309332D1/de not_active Expired - Lifetime
- 1993-12-27 ES ES93810912T patent/ES2129076T5/es not_active Expired - Lifetime
- 1993-12-27 AT AT93810912T patent/ATE175979T1/de active
- 1993-12-27 EP EP93810912A patent/EP0659767B2/de not_active Expired - Lifetime
- 1993-12-27 DK DK93810912T patent/DK0659767T4/da active
-
1994
- 1994-12-21 US US08/360,334 patent/US5593675A/en not_active Expired - Lifetime
- 1994-12-22 NZ NZ278057A patent/NZ278057A/en not_active IP Right Cessation
- 1994-12-22 CA CA002138921A patent/CA2138921C/en not_active Expired - Fee Related
- 1994-12-22 AU AU14143/95A patent/AU682243B2/en not_active Ceased
- 1994-12-22 HU HU9502514A patent/HU216864B/hu not_active IP Right Cessation
- 1994-12-22 KR KR1019950703644A patent/KR100368563B1/ko not_active Expired - Fee Related
- 1994-12-22 WO PCT/EP1994/004267 patent/WO1995018155A1/en not_active Ceased
- 1994-12-22 CZ CZ19952492A patent/CZ286271B6/cs not_active IP Right Cessation
- 1994-12-22 SI SI9420008A patent/SI9420008B/sl unknown
- 1994-12-22 PL PL94310435A patent/PL180358B1/pl not_active IP Right Cessation
- 1994-12-23 NO NO19945032A patent/NO315331B1/no not_active IP Right Cessation
- 1994-12-27 JP JP6337017A patent/JP2926463B2/ja not_active Expired - Fee Related
- 1994-12-27 FI FI946103A patent/FI112168B/fi not_active IP Right Cessation
-
1995
- 1995-01-10 TW TW084100147A patent/TW311884B/zh not_active IP Right Cessation
-
1999
- 1999-03-30 GR GR990400907T patent/GR3029817T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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