ES2129076T3 - Procedimiento para la preparacion de un concentrado de inmunoglobulina g anti-d y composicion farmaceutica que lo contiene. - Google Patents

Procedimiento para la preparacion de un concentrado de inmunoglobulina g anti-d y composicion farmaceutica que lo contiene.

Info

Publication number
ES2129076T3
ES2129076T3 ES93810912T ES93810912T ES2129076T3 ES 2129076 T3 ES2129076 T3 ES 2129076T3 ES 93810912 T ES93810912 T ES 93810912T ES 93810912 T ES93810912 T ES 93810912T ES 2129076 T3 ES2129076 T3 ES 2129076T3
Authority
ES
Spain
Prior art keywords
igg
absorber
plasma
immunoglobulin
concentrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93810912T
Other languages
English (en)
Other versions
ES2129076T5 (es
Inventor
Martin Dr Stucki
Peter Dr Lerch
Gerhard Hodler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Swiss Red Cross
Original Assignee
Swiss Red Cross
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8215103&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2129076(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Swiss Red Cross filed Critical Swiss Red Cross
Application granted granted Critical
Publication of ES2129076T3 publication Critical patent/ES2129076T3/es
Publication of ES2129076T5 publication Critical patent/ES2129076T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/34—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE ELABORA UN PREPARADO G DE ANTI - D - INMUNOGLOBULINA A PARTIR DE PLASMA HUMANO CONTENIENDO ANTI.D IGG O UNA FRACCION DE PLASMA CONTENIENDO ANTI - D IGG, DONDE A) UN PLASMA O LA FRACCION DEL PLASMA SE SOMETE A UNA CROMATOGRAFIA DE INTERCAMBIO DE IONES EN UN VALOR PH EN LA ZONA DESDE 3,5 HASTA 6,5, CON UN ABSORBEDOR, QUE MUESTRA GRUPOS CARBOXIMETIL, GRUPOS FUNCIONALES, DONDE EL ANTI - D IGG ESTA LIGADO AL ABSORBEDOR, B) EL ABSORBEDOR SE LAVA CON ANTI - D - IGG LIGADO EN UNA SOLUCION DE LAVADO, Y A CONTINUACION SE ELUYEN EL ANTI - D IGG, Y ADEMAS C) EL ANTI - D IGG ELUIDO SE TRATA CON UN ABSORBEDOR BASICO CON PROPIEDADES DE INTERCAMBIO DE IONES, PARA LA LIGANDURA DE COMPONENTES NO DESEADOS, Y FINALMENTE SE CONCENTRA EN ANTI - D IGG. EL CONCENTRADO ANTI - D NO INFECCIOSO OBTENIDO CON BUEN RENDIMIENTO POSEE UNA ACTIVIDAD ESPECIFICA DEL MAS DE 0,5 % DE ANTI - D IGG POR GRAMO DE IGG COMPLETO.
ES93810912T 1993-12-27 1993-12-27 Procedimiento para la preparacion de un concentrado de inmunoglobulina g anti-d y composicion farmaceutica que lo contiene. Expired - Lifetime ES2129076T5 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93810912A EP0659767B2 (de) 1993-12-27 1993-12-27 Verfahren zur Herstellung eines Konzentrates von Anti-D-Immunoglobulin G und pharmazeutische Zusammensetzung, die dieses enthält

Publications (2)

Publication Number Publication Date
ES2129076T3 true ES2129076T3 (es) 1999-06-01
ES2129076T5 ES2129076T5 (es) 2003-05-16

Family

ID=8215103

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93810912T Expired - Lifetime ES2129076T5 (es) 1993-12-27 1993-12-27 Procedimiento para la preparacion de un concentrado de inmunoglobulina g anti-d y composicion farmaceutica que lo contiene.

Country Status (20)

Country Link
US (1) US5593675A (es)
EP (1) EP0659767B2 (es)
JP (1) JP2926463B2 (es)
KR (1) KR100368563B1 (es)
AT (1) ATE175979T1 (es)
AU (1) AU682243B2 (es)
CA (1) CA2138921C (es)
CZ (1) CZ286271B6 (es)
DE (1) DE59309332D1 (es)
DK (1) DK0659767T4 (es)
ES (1) ES2129076T5 (es)
FI (1) FI112168B (es)
GR (1) GR3029817T3 (es)
HU (1) HU216864B (es)
NO (1) NO315331B1 (es)
NZ (1) NZ278057A (es)
PL (1) PL180358B1 (es)
SI (1) SI9420008B (es)
TW (1) TW311884B (es)
WO (1) WO1995018155A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE370961T1 (de) * 1998-05-06 2007-09-15 Genentech Inc Reinigung von antikörpern durch ionenaustauschchromatographie
DK2270044T3 (en) * 1998-06-09 2015-01-26 Csl Behring Ag Liquid immunoglobulin G (IgG) product
DE19923027C2 (de) * 1999-05-19 2002-09-19 Aventis Behring Gmbh Verfahren zur Inaktivierung von Viren
US6475749B1 (en) * 1999-08-11 2002-11-05 The Regents Of The University Of California Rh hybrid antibody
SE0001128D0 (sv) * 2000-03-30 2000-03-30 Amersham Pharm Biotech Ab A method of producing IgG
ES2184594B1 (es) 2001-01-17 2004-01-01 Probitas Pharma Sa Procedimiento para la produccion de gammaglobulina g humana inactivada de virus.
EP1532983A1 (en) 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
CA2458750C (en) 2004-02-23 2012-02-07 Bayer Inc. Isoolefin-diolefin production process and apparatus therefor
US20060263357A1 (en) * 2005-05-05 2006-11-23 Tedder Thomas F Anti-CD19 antibody therapy for autoimmune disease
TWI391399B (zh) 2005-05-25 2013-04-01 赫孚孟拉羅股份公司 測定溶離多肽之鹽濃度之方法
KR20090058532A (ko) * 2006-08-28 2009-06-09 아레스 트레이딩 에스.에이. Ｆｃ­융합 단백질을 정제하는 방법
JP2010501623A (ja) * 2006-08-28 2010-01-21 アレス トレーディング ソシエテ アノニム Ｆｃ含有タンパク質の精製法
IT1397061B1 (it) * 2009-12-28 2012-12-28 Kedrion Spa Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale.
DK2531218T3 (en) 2010-02-04 2019-04-01 Csl Behring Ag immunoglobulin
EP2361636A1 (en) 2010-02-26 2011-08-31 CSL Behring AG Immunoglobulin preparation and storage system for an immunoglobulin preparation
RU2467783C2 (ru) * 2010-07-30 2012-11-27 Закрытое акционерное общество "БиоХимМак СТ" Способ хроматографического выделения иммуноглобулина
PL2616090T3 (pl) * 2010-09-17 2023-12-18 Takeda Pharmaceutical Company Limited Stabilizowanie immunoglobulin poprzez wodną formulację z histydyną o ph od słabo kwaśnego do obojętnego
CA2846599A1 (en) * 2011-08-26 2013-03-07 Baxter International Inc. Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition
AU2013203043B2 (en) 2013-03-15 2016-10-06 Takeda Pharmaceutical Company Limited Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs
KR101917196B1 (ko) * 2014-03-11 2018-11-09 주식회사 녹십자홀딩스 면역글로불린의 정제방법
EP3118210B1 (en) * 2014-03-11 2019-11-13 Green Cross Holdings Corporation Method for purifying immunoglobulin
CN121371151A (zh) 2014-12-03 2026-01-23 瑞士杰特贝林生物制品有限公司 具有增加的稳定性的包含免疫球蛋白的药物产品
US12247065B2 (en) * 2018-06-22 2025-03-11 Genmab A/S Method for producing a controlled mixture of two or more different antibodies
CN114456271A (zh) * 2020-11-10 2022-05-10 新疆德源生物工程有限公司 一种Rho(D)人免球蛋白的生产工艺
EP4349859A1 (en) * 2023-01-27 2024-04-10 CSL Behring AG Method to purify anti-d immunoglobulin g from plasma
WO2024156861A1 (en) * 2023-01-27 2024-08-02 Csl Behring Ag Method for reducing protease activity in a solution comprising anti-d immunoglobulin g

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3869436A (en) * 1971-06-01 1975-03-04 Statens Bakteriologiska Lab Method for fractionating plasma proteins using peg and ion-exchangers
EP0085747B2 (de) * 1982-02-08 1990-05-30 Schweizerisches Serum- und Impfinstitut und Institut zur Erforschung der Infektionskrankheiten Intravenös verabreichbares humanes Immunglobulin und Verfahren zu dessen Herstellung
US4434093A (en) * 1982-07-26 1984-02-28 Ortho Diagnostic Systems Inc. Methods for preparation of HBs Ag free gamma globulins
DE3640513A1 (de) * 1986-11-27 1988-06-09 Biotest Pharma Gmbh Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates
US5118796A (en) * 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
US5138034A (en) * 1989-07-12 1992-08-11 The Green Cross Corporation Method of fractionating plasma proteins
US5177194A (en) * 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins

Also Published As

Publication number Publication date
SI9420008B (sl) 1998-06-30
FI946103L (fi) 1995-06-28
DK0659767T3 (da) 1999-09-13
HU9502514D0 (en) 1995-11-28
SI9420008A (en) 1996-02-29
NO315331B1 (no) 2003-08-18
CA2138921C (en) 2004-11-02
AU682243B2 (en) 1997-09-25
EP0659767A1 (de) 1995-06-28
ATE175979T1 (de) 1999-02-15
HU216864B (hu) 1999-09-28
CZ249295A3 (en) 1996-01-17
DE59309332D1 (de) 1999-03-04
NO945032L (no) 1995-06-28
WO1995018155A1 (en) 1995-07-06
CZ286271B6 (cs) 2000-03-15
PL180358B1 (pl) 2001-01-31
NO945032D0 (no) 1994-12-23
KR960701098A (ko) 1996-02-24
FI112168B (fi) 2003-11-14
EP0659767B2 (de) 2002-11-06
FI946103A0 (fi) 1994-12-27
AU1414395A (en) 1995-07-17
KR100368563B1 (ko) 2003-04-03
NZ278057A (en) 1997-03-24
JP2926463B2 (ja) 1999-07-28
CA2138921A1 (en) 1995-06-28
DK0659767T4 (da) 2003-02-10
HUT73376A (en) 1996-07-29
PL310435A1 (en) 1995-12-11
ES2129076T5 (es) 2003-05-16
JPH07206708A (ja) 1995-08-08
TW311884B (es) 1997-08-01
GR3029817T3 (en) 1999-06-30
EP0659767B1 (de) 1999-01-20
US5593675A (en) 1997-01-14

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