ES2129342A1 - "formulacion de vacunas liposomales y su preparacion". - Google Patents
"formulacion de vacunas liposomales y su preparacion".Info
- Publication number
- ES2129342A1 ES2129342A1 ES09602695A ES9602695A ES2129342A1 ES 2129342 A1 ES2129342 A1 ES 2129342A1 ES 09602695 A ES09602695 A ES 09602695A ES 9602695 A ES9602695 A ES 9602695A ES 2129342 A1 ES2129342 A1 ES 2129342A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- antigens
- phospholipids
- formulation
- vaccine formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000009472 formulation Methods 0.000 title abstract 4
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 150000003904 phospholipids Chemical class 0.000 abstract 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Formulación de vacunas liposomales y su preparación. La formulación se refiere a liposomas que contienen antígenos encapsulados en su interior, o bien, asociados a la membrana, con una concentración de fosfolípidos de 25 mg/g respecto al producto final. Los antígenos utilizados pueden ser víricos o fracciones antigénicas de origen bacteriano, como endotoxinas, factores de adhesión, etc. Los fosfolípidos utilizados son mayoritariamente lecitinas. A los fosfolípidos se les puede adicionar, en ocasiones, colesterol y también un antioxidante liposoluble. El procedimiento de preparación consiste en adicionar los fosfolípidos a una suspensión de los antígenos, homogeneizando la mezcla por recirculación por un microfluidificador. La formulación se usa para la preparación de vacunas liposomales de uso veterinario.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9602695A ES2129342B1 (es) | 1996-12-19 | 1996-12-19 | "formulacion de vacunas liposomales y su preparacion". |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9602695A ES2129342B1 (es) | 1996-12-19 | 1996-12-19 | "formulacion de vacunas liposomales y su preparacion". |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2129342A1 true ES2129342A1 (es) | 1999-06-01 |
| ES2129342B1 ES2129342B1 (es) | 2000-03-16 |
Family
ID=8297082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9602695A Expired - Lifetime ES2129342B1 (es) | 1996-12-19 | 1996-12-19 | "formulacion de vacunas liposomales y su preparacion". |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2129342B1 (es) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993004072A1 (en) * | 1991-08-14 | 1993-03-04 | The Associated Octel Company Limited | METAL β-DIKETONATES |
| ES2070774A1 (es) * | 1993-09-16 | 1995-06-01 | Hipra Lab Sa | Preparaciones liposomicas de farmacos o antigenos vacunales para medicina veterinaria. |
| EP0677295A1 (en) * | 1993-10-29 | 1995-10-18 | Tonen Corporation | Liposome having oligosaccharide on the surface |
-
1996
- 1996-12-19 ES ES9602695A patent/ES2129342B1/es not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993004072A1 (en) * | 1991-08-14 | 1993-03-04 | The Associated Octel Company Limited | METAL β-DIKETONATES |
| ES2070774A1 (es) * | 1993-09-16 | 1995-06-01 | Hipra Lab Sa | Preparaciones liposomicas de farmacos o antigenos vacunales para medicina veterinaria. |
| EP0677295A1 (en) * | 1993-10-29 | 1995-10-18 | Tonen Corporation | Liposome having oligosaccharide on the surface |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2129342B1 (es) | 2000-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19990601 Kind code of ref document: A1 Effective date: 19990601 |