ES2129457T3 - Proceso mejorado de sintesis de (5r)-1,1-dimetiletil 6-ciano-5-oxo-hexanoato. - Google Patents

Proceso mejorado de sintesis de (5r)-1,1-dimetiletil 6-ciano-5-oxo-hexanoato.

Info

Publication number
ES2129457T3
ES2129457T3 ES92921435T ES92921435T ES2129457T3 ES 2129457 T3 ES2129457 T3 ES 2129457T3 ES 92921435 T ES92921435 T ES 92921435T ES 92921435 T ES92921435 T ES 92921435T ES 2129457 T3 ES2129457 T3 ES 2129457T3
Authority
ES
Spain
Prior art keywords
ciano
oxo
dimetiletil
hexanoato
synthesis process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92921435T
Other languages
English (en)
Inventor
Donald Eugene Butler
Tung Van Le
Alan Millar
Thomas Norman Nanninga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2129457T3 publication Critical patent/ES2129457T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

SE DESCRIBE UN PROCESO MEJORADO PARA LA PREPARACION DE (5R) -1,1-6DIMELETILO-CIANO-5-HIDROXI-3-OXO EN DONDE UN HIDROXIESTER ASES EN EL PRODUCTO DESEADO
ES92921435T 1991-10-11 1992-10-05 Proceso mejorado de sintesis de (5r)-1,1-dimetiletil 6-ciano-5-oxo-hexanoato. Expired - Lifetime ES2129457T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/775,162 US5155251A (en) 1991-10-11 1991-10-11 Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate

Publications (1)

Publication Number Publication Date
ES2129457T3 true ES2129457T3 (es) 1999-06-16

Family

ID=25103514

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92921435T Expired - Lifetime ES2129457T3 (es) 1991-10-11 1992-10-05 Proceso mejorado de sintesis de (5r)-1,1-dimetiletil 6-ciano-5-oxo-hexanoato.

Country Status (16)

Country Link
US (1) US5155251A (es)
EP (1) EP0643689B1 (es)
JP (2) JP3241723B2 (es)
AT (1) ATE175190T1 (es)
AU (1) AU667320B2 (es)
CA (1) CA2116973C (es)
DE (1) DE69228073T2 (es)
DK (1) DK0643689T3 (es)
ES (1) ES2129457T3 (es)
FI (1) FI941632L (es)
MX (1) MX9205824A (es)
NO (1) NO300208B1 (es)
PT (1) PT100943B (es)
SG (1) SG46599A1 (es)
WO (1) WO1993007115A1 (es)
ZA (1) ZA927793B (es)

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CN101250133B (zh) * 2000-05-31 2010-06-09 中国医学科学院药物研究所 (±)对氟-2-(2-甲基-丙酰基)-4-氧-n，3-二苯基-苯丁酰胺的合成方法以及其中的中间体
US6476235B2 (en) 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
EP1728785A1 (en) 2001-01-09 2006-12-06 Warner-Lambert Company LLC 7-[(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-heptanoic acid ester 3,5-dioxo-acetal
WO2002057229A1 (en) * 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
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SK16002003A3 (sk) 2001-06-29 2004-12-01 Warner-Lambert Company Llc Kryštalické formy vápenatej soli (2:1) [R-(R*,R*)]-2-(4-fluóro- fenyl)-beta,delta-dihydroxy-5-(1-metyletyl)-3-fenyl-4- [(fenylamino)karbonyl]-1H-pyrrol-1-heptánovej kyseliny (atorvastatín)
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JP4765217B2 (ja) * 2001-07-30 2011-09-07 住友化学株式会社 （ｒ）−４−シアノ−３−ヒドロキシブタン酸エステルの製造法
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CN103153976B (zh) * 2010-09-09 2015-07-08 中化帝斯曼制药有限公司荷兰公司 7-氨基-3,5-二羟基庚酸酯的盐
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CN103145584B (zh) * 2013-03-05 2015-08-26 复旦大学 一种合成(3r,5r)-3,5-二羟基-6-氰基己酸酯的方法
CN106397241A (zh) * 2016-08-23 2017-02-15 杨锋 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法

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Also Published As

Publication number Publication date
PT100943B (pt) 1999-07-30
ZA927793B (en) 1994-04-11
CA2116973A1 (en) 1993-04-15
NO941280D0 (no) 1994-04-08
NO941280L (no) 1994-04-08
EP0643689A1 (en) 1995-03-22
AU2764192A (en) 1993-05-03
DE69228073T2 (de) 1999-06-10
FI941632A7 (fi) 1994-04-08
EP0643689B1 (en) 1998-12-30
JP3429500B2 (ja) 2003-07-22
AU667320B2 (en) 1996-03-21
FI941632A0 (fi) 1994-04-08
SG46599A1 (en) 1998-02-20
PT100943A (pt) 1993-10-29
FI941632L (fi) 1994-04-08
DE69228073D1 (de) 1999-02-11
CA2116973C (en) 2004-09-21
NO300208B1 (no) 1997-04-28
ATE175190T1 (de) 1999-01-15
JP2002030060A (ja) 2002-01-29
JP3241723B2 (ja) 2001-12-25
DK0643689T3 (da) 1999-08-30
WO1993007115A1 (en) 1993-04-15
MX9205824A (es) 1993-04-01
JPH07500105A (ja) 1995-01-05
US5155251A (en) 1992-10-13

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