ES2131015A1 - Nuevos derivados de 2-(3h)-oxazolona, procedimientos para su preparacion y su empleo en composiciones farmaceuticas. - Google Patents

Nuevos derivados de 2-(3h)-oxazolona, procedimientos para su preparacion y su empleo en composiciones farmaceuticas.

Info

Publication number
ES2131015A1
ES2131015A1 ES09701928A ES9701928A ES2131015A1 ES 2131015 A1 ES2131015 A1 ES 2131015A1 ES 09701928 A ES09701928 A ES 09701928A ES 9701928 A ES9701928 A ES 9701928A ES 2131015 A1 ES2131015 A1 ES 2131015A1
Authority
ES
Spain
Prior art keywords
new
alkyl
oxazolone derivatives
group
oxazolone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09701928A
Other languages
English (en)
Other versions
ES2131015B1 (es
Inventor
Duran Carles Puig
Gras Joan Feixas
Mayorga Juan Miguel Jimenez
Crespo Maria Isabel Crespo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall Prodesfarma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma SA filed Critical Almirall Prodesfarma SA
Priority to ES009701928A priority Critical patent/ES2131015B1/es
Priority to PCT/EP1998/005694 priority patent/WO1999014205A1/en
Priority to EP98950000A priority patent/EP1017685A1/en
Priority to JP2000511756A priority patent/JP2001516750A/ja
Priority to AU96236/98A priority patent/AU9623698A/en
Priority to CO98051845A priority patent/CO5011110A1/es
Priority to ZA988303A priority patent/ZA988303B/xx
Priority to PE1998000863A priority patent/PE116999A1/es
Priority to ARP980104535A priority patent/AR017097A1/es
Priority to UY25179A priority patent/UY25179A1/es
Publication of ES2131015A1 publication Critical patent/ES2131015A1/es
Application granted granted Critical
Publication of ES2131015B1 publication Critical patent/ES2131015B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Nuevos derivados de 2-(3H)-oxazolona, procedimientos para su preparación y su empleo en composiciones farmacéuticas. El compuesto 2-(3H)-oxazolona preferido tiene la fórmula (I):en donde los significados de los distintos radicales son como se han indicado en la parte descriptiva. El procedimiento se caracteriza porque por reacciones de diferentes compuestos de partida e intermedios se obtienen los nuevos derivados de 2-(3H)-oxazolona. Estos se pueden emplear como compuestos activos en composiciones farmacéuticas para el tratamiento de enfermedades mediadas por ciclooxigenasa-2.
ES009701928A 1997-09-12 1997-09-12 Nuevos derivados de 2-(3h)-oxazolona, procedimientos para su preparacion y su empleo en composiciones farmaceuticas. Expired - Fee Related ES2131015B1 (es)

Priority Applications (10)

Application Number Priority Date Filing Date Title
ES009701928A ES2131015B1 (es) 1997-09-12 1997-09-12 Nuevos derivados de 2-(3h)-oxazolona, procedimientos para su preparacion y su empleo en composiciones farmaceuticas.
PCT/EP1998/005694 WO1999014205A1 (en) 1997-09-12 1998-09-08 New 2-(3h)-oxazolone derivatives
EP98950000A EP1017685A1 (en) 1997-09-12 1998-09-08 New 2-(3h)-oxazolone derivatives
JP2000511756A JP2001516750A (ja) 1997-09-12 1998-09-08 新規な２−（３ｈ）−オキサゾロン誘導体
AU96236/98A AU9623698A (en) 1997-09-12 1998-09-08 New 2-(3h)-oxazolone derivatives
CO98051845A CO5011110A1 (es) 1997-09-12 1998-09-09 Nuevos derivados de 2-(3h)-oxazolona
ZA988303A ZA988303B (en) 1997-09-12 1998-09-10 New 2-(3H)-oxazolone derivatives
PE1998000863A PE116999A1 (es) 1997-09-12 1998-09-10 Nuevos derivados de 2-(3h)-oxazolona
ARP980104535A AR017097A1 (es) 1997-09-12 1998-09-11 Compuestos de 2-(3h)-oxazolona, utiles como inhibidores selectivos de cox-2; procedimiento para preparar dichos compuestos y composiciones farmaceuticasformuladas con dichos compuestos
UY25179A UY25179A1 (es) 1997-09-12 1998-09-11 Nuevos derivados de 2-(3h)-oxazolona

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009701928A ES2131015B1 (es) 1997-09-12 1997-09-12 Nuevos derivados de 2-(3h)-oxazolona, procedimientos para su preparacion y su empleo en composiciones farmaceuticas.

Publications (2)

Publication Number Publication Date
ES2131015A1 true ES2131015A1 (es) 1999-07-01
ES2131015B1 ES2131015B1 (es) 2000-03-01

Family

ID=8300586

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009701928A Expired - Fee Related ES2131015B1 (es) 1997-09-12 1997-09-12 Nuevos derivados de 2-(3h)-oxazolona, procedimientos para su preparacion y su empleo en composiciones farmaceuticas.

Country Status (10)

Country Link
EP (1) EP1017685A1 (es)
JP (1) JP2001516750A (es)
AR (1) AR017097A1 (es)
AU (1) AU9623698A (es)
CO (1) CO5011110A1 (es)
ES (1) ES2131015B1 (es)
PE (1) PE116999A1 (es)
UY (1) UY25179A1 (es)
WO (1) WO1999014205A1 (es)
ZA (1) ZA988303B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
ATE283048T1 (de) 1999-12-08 2004-12-15 Pharmacia Corp Cyclooxygenase-2 hemmer enthaltende zusammensetzungen mit schnellem wirkungseintritt
ES2166710B1 (es) * 2000-04-25 2004-10-16 J. URIACH & CIA, S.A. Nuevos compuestos heterociclicos con actividad antiinflamatoria.
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US6673818B2 (en) 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
ES2213485B1 (es) 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. Derivados de la 2-fenilpiran-4-ona.
WO2022195579A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027980A1 (en) * 1993-05-21 1994-12-08 G.D. Searle & Co. Substituted oxazolyl compounds for the treatment of inflammation
WO1996036617A1 (en) * 1995-05-19 1996-11-21 G.D. Searle & Co. Substituted oxazoles for the treatment of inflammation
WO1997034882A1 (en) * 1996-03-21 1997-09-25 Almirall Prodesfarma, S.A. 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors
WO1998011080A1 (fr) * 1996-09-13 1998-03-19 Laboratoires Upsa Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027980A1 (en) * 1993-05-21 1994-12-08 G.D. Searle & Co. Substituted oxazolyl compounds for the treatment of inflammation
WO1996036617A1 (en) * 1995-05-19 1996-11-21 G.D. Searle & Co. Substituted oxazoles for the treatment of inflammation
WO1997034882A1 (en) * 1996-03-21 1997-09-25 Almirall Prodesfarma, S.A. 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors
WO1998011080A1 (fr) * 1996-09-13 1998-03-19 Laboratoires Upsa Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique

Also Published As

Publication number Publication date
UY25179A1 (es) 2000-12-29
ZA988303B (en) 1999-03-11
AU9623698A (en) 1999-04-05
JP2001516750A (ja) 2001-10-02
CO5011110A1 (es) 2001-02-28
WO1999014205A1 (en) 1999-03-25
EP1017685A1 (en) 2000-07-12
ES2131015B1 (es) 2000-03-01
AR017097A1 (es) 2001-08-22
PE116999A1 (es) 1999-12-13

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