ES2131972T3 - Derivados de sulfamato de derivados del 1,3,5(10)-estratrieno, procedimiento para su fabricacion y composiciones farmaceuticas que contienen estos compuestos. - Google Patents

Derivados de sulfamato de derivados del 1,3,5(10)-estratrieno, procedimiento para su fabricacion y composiciones farmaceuticas que contienen estos compuestos.

Info

Publication number
ES2131972T3
ES2131972T3 ES96945140T ES96945140T ES2131972T3 ES 2131972 T3 ES2131972 T3 ES 2131972T3 ES 96945140 T ES96945140 T ES 96945140T ES 96945140 T ES96945140 T ES 96945140T ES 2131972 T3 ES2131972 T3 ES 2131972T3
Authority
ES
Spain
Prior art keywords
derivatives
compounds
stratriene
sulfamate
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96945140T
Other languages
English (en)
Inventor
Sigfrid Schwarz
Walter Elger
Gudrun Reddersen
Birgitt Schneider
Ina Thieme
Margit Richter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jenapharm GmbH and Co KG
Original Assignee
Jenapharm GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenapharm GmbH and Co KG filed Critical Jenapharm GmbH and Co KG
Application granted granted Critical
Publication of ES2131972T3 publication Critical patent/ES2131972T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA INVENCION SE RELACIONA CON NUEVOS DERIVADOS SULFAMATOS DE DERIVADOS DEL 1,3,5(10) ESTRATRIENO DE FORMULA GENERAL (I) EN LA QUE EL GRUPO 3-SULFAMATO SE ACILA, SULFONA O AMINOSULFONA. SE DESCRIBEN TAMBIEN METODOS PARA PRODUCIR ESTAS SUSTANCIAS Y LOS COMPUESTOS FARMACEUTICOS QUE LOS CONTIENEN. LOS COMPUESTOS REIVINDICADOS TIENEN PROPIEDADES SIMILARES A LAS PROPIEDADES DE LOS ESTROGENOS.
ES96945140T 1995-10-19 1996-09-19 Derivados de sulfamato de derivados del 1,3,5(10)-estratrieno, procedimiento para su fabricacion y composiciones farmaceuticas que contienen estos compuestos. Expired - Lifetime ES2131972T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19540233A DE19540233B4 (de) 1995-10-19 1995-10-19 Sulfamat-Derivate von 1,3,5(10)-Estratrien-Derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number Publication Date
ES2131972T3 true ES2131972T3 (es) 1999-08-01

Family

ID=7776061

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96945140T Expired - Lifetime ES2131972T3 (es) 1995-10-19 1996-09-19 Derivados de sulfamato de derivados del 1,3,5(10)-estratrieno, procedimiento para su fabricacion y composiciones farmaceuticas que contienen estos compuestos.

Country Status (13)

Country Link
EP (1) EP0862577B1 (es)
JP (2) JPH11505268A (es)
KR (1) KR100306044B1 (es)
CN (1) CN1125077C (es)
AT (1) ATE178903T1 (es)
AU (1) AU1436097A (es)
BR (1) BR9610905A (es)
DE (2) DE19540233B4 (es)
DK (1) DK0862577T3 (es)
ES (1) ES2131972T3 (es)
GR (1) GR3030733T3 (es)
RU (1) RU2159774C2 (es)
WO (1) WO1997014712A2 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
DE19712488A1 (de) * 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
US6288050B1 (en) * 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
ATE401896T1 (de) 1998-06-10 2008-08-15 Sterix Ltd Pharmazeutische zusammensetzungen mit tumor nekrose faktor und 2-methoxyestron-3-o-sulphamat als estrone sulphatasehemmern
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
DE19943708B4 (de) * 1999-09-08 2007-12-20 Bayer Schering Pharma Ag Neue C13-substituierte Estra-1,3,5(10)-trien-3-yl-sulfamate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US6583130B1 (en) 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
EP1769799A3 (en) * 2000-01-14 2010-01-13 Sterix Limited Pharmaceutical compositions containing steroidal structures and uses thereof
DE10027887A1 (de) * 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
DE10139494A1 (de) * 2001-08-13 2003-03-06 Jenapharm Gmbh Antitumor wirksame 2-Alkoxyestradiolsulfamate
DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
DE10307104A1 (de) * 2003-02-19 2004-09-23 Schering Ag Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
DE10307103A1 (de) 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
US20080292765A1 (en) * 2007-05-22 2008-11-27 The Coca-Cola Company Sweetness Enhancers, Sweetness Enhanced Sweetener Compositions, Methods for Their Formulation, and Uses
GB201302368D0 (en) * 2013-02-11 2013-03-27 Univ Bath Compound
RU2562242C1 (ru) * 2014-07-10 2015-09-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) РАЦЕМИЧЕСКИЙ 2,17β-ДИСУЛЬФАМОИЛОКСИ-3-МЕТОКСИ-8α-ЭСТРА-1,3,5(10)-ТРИЕН В КАЧЕСТВЕ ИНГИБИТОРА ПРОЛИФЕРАЦИИ ОПУХОЛЕВЫХ КЛЕТОК MCF-7

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2133484A2 (en) * 1969-04-29 1972-12-01 Jenapharm Veb 3-17 and 21-sulphonyloxy-steroids - with androgenic anabolic progestogenic and oestrogen activity of long duration
IL94183A (en) * 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
DE69032616T2 (de) * 1989-06-16 1999-03-11 Genencor International, Inc., Rochester, N.Y. Dna-sequenzen, vektoren und fusionspolypeptide zur erhöhung der sekretion gewünschter polypeptide von filamentösen fungi
JP2818056B2 (ja) * 1990-09-07 1998-10-30 森永乳業株式会社 抗菌性ペプチドおよび抗菌剤
ZA932568B (en) * 1992-04-24 1993-11-12 Baylor College Midecine A Non Production of recombinant human lactoferrin

Also Published As

Publication number Publication date
DK0862577T3 (da) 1999-10-25
EP0862577B1 (de) 1999-04-14
AU1436097A (en) 1997-05-07
CN1200126A (zh) 1998-11-25
ATE178903T1 (de) 1999-04-15
DE19540233A1 (de) 1997-04-24
DE59601683D1 (de) 1999-05-20
BR9610905A (pt) 1999-07-13
DE19540233B4 (de) 2005-08-25
GR3030733T3 (en) 1999-11-30
EP0862577A2 (de) 1998-09-09
JPH11505268A (ja) 1999-05-18
KR19990064144A (ko) 1999-07-26
CN1125077C (zh) 2003-10-22
WO1997014712A2 (de) 1997-04-24
JP3040175B2 (ja) 2000-05-08
WO1997014712A3 (de) 1997-06-05
RU2159774C2 (ru) 2000-11-27
KR100306044B1 (ko) 2001-12-05

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