ES2132170T3 - Composicion de esteres de l-dopa. - Google Patents

Composicion de esteres de l-dopa.

Info

Publication number
ES2132170T3
ES2132170T3 ES93120894T ES93120894T ES2132170T3 ES 2132170 T3 ES2132170 T3 ES 2132170T3 ES 93120894 T ES93120894 T ES 93120894T ES 93120894 T ES93120894 T ES 93120894T ES 2132170 T3 ES2132170 T3 ES 2132170T3
Authority
ES
Spain
Prior art keywords
composition
active ingredient
dopa
weight
dopa esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93120894T
Other languages
English (en)
Inventor
Isaac Milman
Alexander Veinberg
Daphne Atlas
Eldad Melamed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Teva Pharmaceutical Industries Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd, Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Teva Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of ES2132170T3 publication Critical patent/ES2132170T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE PRESENTA UNA COMPOSICION QUE COMPRENDE UN PORTADOR FARMACEUTICAMENTE ACEPTABLE Y UN INGREDIENTE ACTIVO, EL INGREDIENTE ACTIVO COMPRENDE UN ESTER DE ETIL DE L-DOPA EN UNA CANTIDAD QUE ES AL MENOS EL 97% DEL PESO DEL INGREDIENTE ACTIVO Y L-DOPA EN UNA CANTIDAD QUE ES MENOR DEL 1% DEL PESO DE DICHO INGREDIENTE ACTIVO. LA INVENCION SUMINISTRA ADEMAS UN PROCESO PARA PREPARAR DICHA COMPOSICION. ADEMAS, ESTA INVENCION SUMINISTRA UN METODO PARA TRATAR A UN PACIENTE QUE SUFRA DE LA ENFERMEDAD DE PARKINSON QUE COMPRENDE LA ADMINISTRACION AL PACIENTE DE UNA COMPOSICION FARMACEUTICA QUE COMPRENDA UNA CANTIDAD TERAPEUTICAMENTE EFECTIVA DE ESTER DE ETIL DE L-DOPA Y UN PORTADOR FARMACOLOGICAMENTE ACEPTABLE.
ES93120894T 1992-12-24 1993-12-24 Composicion de esteres de l-dopa. Expired - Lifetime ES2132170T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/995,847 US5354885A (en) 1992-12-24 1992-12-24 Process for preparing ethyl ester of L-DOPA

Publications (1)

Publication Number Publication Date
ES2132170T3 true ES2132170T3 (es) 1999-08-16

Family

ID=25542272

Family Applications (2)

Application Number Title Priority Date Filing Date
ES98101741T Expired - Lifetime ES2150294T3 (es) 1992-12-24 1993-12-24 Composicion de esteres de l-dopa.
ES93120894T Expired - Lifetime ES2132170T3 (es) 1992-12-24 1993-12-24 Composicion de esteres de l-dopa.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES98101741T Expired - Lifetime ES2150294T3 (es) 1992-12-24 1993-12-24 Composicion de esteres de l-dopa.

Country Status (20)

Country Link
US (2) US5354885A (es)
EP (2) EP0867179B1 (es)
JP (1) JPH07285860A (es)
CN (1) CN1083262C (es)
AT (2) ATE178793T1 (es)
AU (1) AU684053B2 (es)
CA (1) CA2112160A1 (es)
CY (1) CY2214B1 (es)
DE (2) DE69329400T2 (es)
DK (2) DK0867179T3 (es)
ES (2) ES2150294T3 (es)
FI (1) FI107994B (es)
GR (2) GR3030073T3 (es)
HU (1) HU218906B (es)
IL (1) IL108147A (es)
LV (1) LV12766B (es)
NO (1) NO305932B1 (es)
NZ (1) NZ250541A (es)
PT (1) PT867179E (es)
ZA (1) ZA939573B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9203594D0 (sv) * 1992-11-30 1992-11-30 Christer Nystroem Laekemedel i dispersa system
US5840756A (en) * 1995-07-21 1998-11-24 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition of L-DOPA ester
AU7669496A (en) * 1995-11-03 1997-05-22 University Of Kentucky Method for the intranasal administration of l-dopa prodrugs
CA2236368C (en) * 1995-11-06 2001-10-23 Somerset Pharmaceuticals, Inc. Sublingual and buccal administration of selegiline
US6166081A (en) * 1997-10-09 2000-12-26 Kushnir; Moshe Methods and apparatus for treatment of Parkinson's disease
AU768154B2 (en) * 1996-10-13 2003-12-04 Neuroderm Ltd Treatment of Parkinson's disease
IL119417A (en) * 1996-10-13 2003-02-12 Moshe Kushnir Pharmaceutical composition for transdermal administration of levodopa for parkinson's disease
US6746688B1 (en) 1996-10-13 2004-06-08 Neuroderm Ltd. Apparatus for the transdermal treatment of Parkinson's disease
BR9908713A (pt) 1998-03-16 2000-11-21 Somerset Pharmaceuticals Inc Uso de selegilina ou desmetil-selegilina para tratamento de feridas, queimaduras e danos dermatológicos
JP2002529407A (ja) * 1998-11-10 2002-09-10 テバ ファーマシューティカル インダストリーズ リミティド Ｌ−ｄｏｐａエチルエステル含有分散性組成物
EP1137626A4 (en) * 1998-11-10 2002-07-17 Teva Pharma METHOD FOR PRODUCING L-DOPA ETHYLESTER
RU2157196C1 (ru) * 1999-06-17 2000-10-10 Васильев Виталий Николаевич Фармацевтическая композиция в.н. васильева для восстановления функции симпатико-адреналовой системы, способ оценки индивидуальной эффективности этой композиции для терапии пациентов
RU2173150C1 (ru) * 2000-06-27 2001-09-10 Васильев Виталий Николаевич Фармацевтическая композиция для биокоррекции симпатико-адреналовой системы
US6613308B2 (en) * 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US6514482B1 (en) * 2000-09-19 2003-02-04 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US6531153B2 (en) * 2001-05-29 2003-03-11 Drugtech Corporation Composition with sustained release of levodopa and carbidopa
IL159813A0 (en) * 2001-07-12 2004-06-20 Teva Pharma Dual release formulation comprising levodopa ethyl ester and a decarboxylase inhibitor in immediate release layer with levodopa ethyl ester and a decarboxylase inhibitor in a controlled release core
AU2002340470A1 (en) * 2001-11-13 2003-05-26 Teva Pharmaceutical Industries, Ltd. L-dopa ethyl ester salts and uses thereof
US20030135065A1 (en) * 2001-11-13 2003-07-17 Ramy Lidor-Hadas Process for the production of L-DOPA ethyl ester
HUE031167T2 (hu) 2002-03-20 2017-07-28 Civitas Therapeutics Inc A levodopa pulmonális bejuttatása
US6930137B2 (en) * 2002-05-31 2005-08-16 Fina Technology, Inc. Method of improving blown film processing performance and physical properties
DE10261807A1 (de) 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel
EP1596808A4 (en) * 2003-02-07 2007-04-04 Yissum Res Dev Co L-DOPA AMID DERIVATIVES AND THEIR USE
EP1622450A4 (en) * 2003-04-25 2009-11-18 Endo Pharmaceuticals Solutions PROCESS FOR PROMOTING UNINTERRUPTED SLEEP BY ADMINISTERING TROPIUM CHLORIDE
KR100525358B1 (ko) * 2003-08-21 2005-11-04 주식회사 이엔에프테크놀로지 카르복실 벤조트리아졸 알킬에스테르의 제조방법
JP5160786B2 (ja) * 2003-08-29 2013-03-13 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 医薬組成物及びレボドパ及びカルビドパの使用方法
US8815950B2 (en) 2003-08-29 2014-08-26 Janssen Biotech, Inc. Pharmaceutical compositions and method of using levodopa and carbidopa
US7691880B2 (en) * 2003-10-08 2010-04-06 Mallinckrodt Inc. Methylphenidate solution and associated methods of administration and production
SE0401842D0 (sv) * 2004-07-12 2004-07-12 Dizlin Medical Design Ab Infusion and injection solution of levodopa
BRPI0708071A8 (pt) * 2006-02-17 2017-12-26 Birds Pharma Gmbh Berolina Innovative Res & Development Services Derivados de catecolamina deuterada e medicamentos compreendendo os ditos compostos
CN101623278B (zh) * 2008-07-09 2013-02-27 北京德众万全药物技术开发有限公司 一种含有左旋多巴和盐酸苄丝肼的药物组合物
AU2016258179B2 (en) 2015-05-06 2021-07-01 Synagile Corporation Pharmaceutical suspensions containing drug particles, devices for their administration, and methods of their use
WO2017032874A1 (en) * 2015-08-27 2017-03-02 Prexton Therapeutics Sa Brain-penetrant chromone oxime derivative for the therapy of levodopa-induced dyskinesia
EP3518920A1 (en) 2016-09-29 2019-08-07 Berlirem GmbH L-dopa derivatives for the treatment of neurological diseases
PT4039093T (pt) 2021-02-09 2023-10-20 Biobab R&D S L Star Método e utilização de enantiómeros de 3,4-dihidroxifenilalanina (dopa) para aumentar a atratividade das plantas para insetos benéficos

Family Cites Families (9)

* Cited by examiner, † Cited by third party
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ZA716958B (en) * 1970-10-30 1973-01-31 Hoffmann La Roche Phenylalanine amides
US3803120A (en) * 1971-09-28 1974-04-09 Hoffmann La Roche Di-and tripeptides of 3-(3,4-dihydroxyphenyl)-alanine
US3939253A (en) * 1973-11-02 1976-02-17 Interx Research Corporation Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease
JPS5157813A (en) * 1974-11-14 1976-05-20 Sankyo Co Ll dooba mataha sonojudotaiseizaino seiho
US4035507A (en) * 1975-04-17 1977-07-12 Interx Research Corporation Novel, transient pro-drug forms of L-DOPA to treat Parkinson's disease
US4916151A (en) * 1985-12-05 1990-04-10 Merrell Dow Pharmaceuticals Inc. Method of treating parkinson's syndrome
US4663349A (en) * 1985-12-30 1987-05-05 Merck & Co., Inc. Rectally absorbable form of L-dopa
US4771073A (en) * 1985-12-30 1988-09-13 Merck & Co., Inc. Rectally absorbable form of L-dopa
ES2042520T3 (es) * 1986-06-10 1993-12-16 Chiesi Farma Spa Composiciones farmaceuticas que contienen el ester metilico de levodopa, preparacion y aplicaciones terapeuticas del mismo.

Also Published As

Publication number Publication date
NO934768L (no) 1994-06-27
ES2150294T3 (es) 2000-11-16
FI935847A0 (fi) 1993-12-23
NO305932B1 (no) 1999-08-23
HU9303748D0 (en) 1994-04-28
CN1083262C (zh) 2002-04-24
LV12766A (lv) 2001-12-20
ZA939573B (en) 1994-08-11
GR3034867T3 (en) 2001-02-28
EP0867179B1 (en) 2000-09-06
IL108147A0 (en) 1994-04-12
AU684053B2 (en) 1997-12-04
DE69324466T2 (de) 1999-11-25
CN1094950A (zh) 1994-11-16
LV12766B (en) 2002-03-20
EP0610595A2 (en) 1994-08-17
CA2112160A1 (en) 1994-06-25
HK1012577A1 (en) 1999-08-06
US5525631A (en) 1996-06-11
DK0867179T3 (da) 2000-11-06
NO934768D0 (no) 1993-12-22
FI107994B (fi) 2001-11-15
FI935847L (fi) 1994-06-25
PT867179E (pt) 2000-12-29
HU218906B (hu) 2000-12-28
EP0610595A3 (en) 1994-09-21
NZ250541A (en) 1995-12-21
ATE178793T1 (de) 1999-04-15
IL108147A (en) 1998-09-24
US5354885A (en) 1994-10-11
DE69324466D1 (de) 1999-05-20
DK0610595T3 (da) 1999-10-25
AU5257793A (en) 1994-07-07
DE69329400T2 (de) 2001-01-18
EP0867179A1 (en) 1998-09-30
CY2214B1 (en) 2002-11-08
EP0610595B1 (en) 1999-04-14
ATE196081T1 (de) 2000-09-15
DE69329400D1 (de) 2000-10-12
GR3030073T3 (en) 1999-07-30
HUT68498A (en) 1995-06-28
JPH07285860A (ja) 1995-10-31

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