ES2133183T3 - Procedimiento para la obtencion de 2,2-difluorbenzo(1,3)dioxocarbaldehidos. - Google Patents

Procedimiento para la obtencion de 2,2-difluorbenzo(1,3)dioxocarbaldehidos.

Info

Publication number
ES2133183T3
ES2133183T3 ES96112760T ES96112760T ES2133183T3 ES 2133183 T3 ES2133183 T3 ES 2133183T3 ES 96112760 T ES96112760 T ES 96112760T ES 96112760 T ES96112760 T ES 96112760T ES 2133183 T3 ES2133183 T3 ES 2133183T3
Authority
ES
Spain
Prior art keywords
dioxocarbaldehidos
difluorbenzo
procedure
obtaining
dichlorometil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96112760T
Other languages
English (en)
Inventor
Peter Dr Andres
Albrecht Dr Marhold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2133183T3 publication Critical patent/ES2133183T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

SE OBTIENEN DE MANERA ESPECIALMENTE VENTAJOSA 2,2-DIFLUOROBENZO-(1,3)DIOXO-CARBALDEHIDOS, SI SE CLORA METIL-BENZO-[1,3]DIOXOLES, SE FLUORA EL DICLOROMETIL-2,2-DICLORO-BENZO-[1,3]DIOXOL OBTENIDO CON ACIDO FLUORHIDRICO, Y SE HACE REACCIONAR EL DICLOROMETIL-2,2-DIFLUOROBENZO-[1,3]-DIOXOL OBTENIDO CON UN ACIDO CARBOXILICO.
ES96112760T 1995-08-21 1996-08-08 Procedimiento para la obtencion de 2,2-difluorbenzo(1,3)dioxocarbaldehidos. Expired - Lifetime ES2133183T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19530637A DE19530637A1 (de) 1995-08-21 1995-08-21 Verfahren zur Herstellung von 2,2-Difluorbenzo[1.3]dioxolcarbaldehyden

Publications (1)

Publication Number Publication Date
ES2133183T3 true ES2133183T3 (es) 1999-09-01

Family

ID=7769957

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96112760T Expired - Lifetime ES2133183T3 (es) 1995-08-21 1996-08-08 Procedimiento para la obtencion de 2,2-difluorbenzo(1,3)dioxocarbaldehidos.

Country Status (6)

Country Link
US (1) US5637737A (es)
EP (1) EP0759433B1 (es)
JP (1) JPH0967366A (es)
CA (1) CA2183491A1 (es)
DE (2) DE19530637A1 (es)
ES (1) ES2133183T3 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031563A1 (it) * 2003-07-30 2005-01-31 Miteni Spa Processo di fluorurazione di eteri.
DE102004024010A1 (de) * 2004-05-14 2005-12-01 Bayer Chemicals Ag Verfahren zur Herstellung von Difluorbenzo-1,3-dioxol-5-carbonsäurederivaten
CN101160281A (zh) * 2005-04-06 2008-04-09 特瓦制药工业有限公司 结晶形态的普瑞巴林
MX2007012606A (es) * 2005-04-11 2008-01-11 Teva Pharma Proceso para elaborar (s)-pregabalina.
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
ES2372700T3 (es) * 2005-05-10 2012-01-25 Teva Pharmaceutical Industries Ltd Resolución óptica del ácido 3-carbamoilmetil-5-metil hexanoico.
WO2006122258A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Method for the preparation of pregabalin and salts thereof
MX2007000525A (es) 2005-05-10 2007-03-28 Teva Pharma Pregabalina libre de acido isobutilglutarico y un proceso para la preparacion de ella.
WO2007035789A1 (en) * 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the new synthesis of (s)-pregabalin
WO2007127309A2 (en) * 2006-04-24 2007-11-08 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of 3-isobutylglutaric acid
WO2007139933A2 (en) * 2006-05-24 2007-12-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
WO2007143152A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
WO2007143113A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. The use of enzymatic resolution for the preparation of intermediates of pregabalin
TW200846308A (en) * 2007-03-22 2008-12-01 Teva Pharma Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
WO2009046309A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
WO2009158343A1 (en) * 2008-06-23 2009-12-30 Teva Pharmaceutical Industries, Ltd. Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
CN101851225B (zh) * 2010-06-09 2012-08-08 山东铂源化学有限公司 一种咯菌腈中间体4-醛基-2,2-二氟苯并二恶茂的合成方法
WO2013047749A1 (ja) * 2011-09-29 2013-04-04 三井化学アグロ株式会社 ４，４－ジフルオロ－３，４－ジヒドロイソキノリン誘導体の製造方法
CN120230074B (zh) * 2025-06-03 2025-09-23 淮北龙溪生物科技有限公司 一种咯菌腈中间体的高效合成工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3716652A1 (de) * 1987-05-19 1988-12-08 Bayer Ag Dioxyalkylenaryl-dihydropyridine, zwischenprodukte zu ihrer herstellung, verfahren zu ihrer herstellung und ihre verwendung
US5194628A (en) * 1988-03-18 1993-03-16 Ciba-Geigy Corporation Process for the preparation of substituted difluorobenzo-1,3-dioxoles
CH687877A5 (de) * 1988-03-18 1997-03-14 Ciba Geigy Ag 2,2-Difluorbenzo-1,3-dioxol-4-carbaldehyd.
CH676119A5 (en) * 1988-06-22 1990-12-14 Ciba Geigy Ag 2,2-Di:chloro-1,3-benzodioxole derivs. prodn. - by reacting 2-unsubstituted cpd. with chlorine and phosphorus tri:chloride, useful as pesticide intermediates
DE4133155A1 (de) * 1991-10-07 1993-04-08 Bayer Ag Verfahren zur herstellung von 2,2-difluorbenzo (1,3)-dioxol-carbaldehyden und neuen zwischenprodukten

Also Published As

Publication number Publication date
JPH0967366A (ja) 1997-03-11
EP0759433A1 (de) 1997-02-26
DE19530637A1 (de) 1997-02-27
EP0759433B1 (de) 1999-06-16
CA2183491A1 (en) 1997-02-22
DE59602230D1 (de) 1999-07-22
US5637737A (en) 1997-06-10

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