ES2133269T3 - Gen receptor del factor de crecimiento derivado de plaquetas de tipo oc. - Google Patents

Gen receptor del factor de crecimiento derivado de plaquetas de tipo oc.

Info

Publication number
ES2133269T3
ES2133269T3 ES90905022T ES90905022T ES2133269T3 ES 2133269 T3 ES2133269 T3 ES 2133269T3 ES 90905022 T ES90905022 T ES 90905022T ES 90905022 T ES90905022 T ES 90905022T ES 2133269 T3 ES2133269 T3 ES 2133269T3
Authority
ES
Spain
Prior art keywords
image
amino acid
pdgfr
growth factor
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90905022T
Other languages
English (en)
Inventor
Toshimitsu Matsui
Stuart A Aaronson
Jacalyn H Pierce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Government of the United States of America
Original Assignee
US Department of Health and Human Services
Government of the United States of America
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services, Government of the United States of America filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of ES2133269T3 publication Critical patent/ES2133269T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A61K51/103—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants against receptors for growth factors or receptors for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/49—Platelet-derived growth factor [PDGF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBEN DESCUBRIMIENTOS QUE MUESTRAN ASPECTOS DETERMINADOS DE TECNOLOGIA DE ADN RECOMBINANTE QUE PUEDEN UTILIZARSE CON EXITO PARA PRODUCIR UN TIPO DE PROTEINA HUMANA RECEPTORA DE FACTOR DE CRECIMIENTO DERIVADO DE PLAQUETA (PDGF) HASTA AHORA DESCONOCIDO (VER MAPA GENETICO, FIGURA 2) LIBRE DE OTROS RECEPTORES PDGF. ESTAS PROTEINAS PUEDEN PRODUCIRSE A PARTIR DE SEGMENTOS DE ADN EN CELULAS EN VARIAS FORMAS FUNCIONALES. ESTAS FORMAS PERMITEN ESTUDIOS FUNCIONALES Y BIOQUIMICOS DE DIVERSOS MODOS DE ESTOS NUEVOS RECEPTORES, ASI COMO LA PRODUCCION DE ANTICUERPOS. SE DESCRIBEN MEDIOS PARA DETERMINAR EL NIVEL DE EXPRESION DE GENES PARA TIPOS ESPECIFICOS DE PROTEINAS RECEPTORAS DE PDGF, POR EJEMPLO , MIDIENDO EL ARNM EN LA CELULA CON PRUEBAS DE ADN DE TIPO ESPECIFICO RECEPTOR PDGF O MIDIENDO EL ANTIGENO EN MUESTRAS BIOLOGICAS CON ANTICUERPOS DE TIPO ESPECIFICO.
ES90905022T 1989-02-09 1990-02-08 Gen receptor del factor de crecimiento derivado de plaquetas de tipo oc. Expired - Lifetime ES2133269T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30828289A 1989-02-09 1989-02-09

Publications (1)

Publication Number Publication Date
ES2133269T3 true ES2133269T3 (es) 1999-09-16

Family

ID=23193333

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90905022T Expired - Lifetime ES2133269T3 (es) 1989-02-09 1990-02-08 Gen receptor del factor de crecimiento derivado de plaquetas de tipo oc.

Country Status (11)

Country Link
US (2) US7427671B1 (es)
EP (2) EP0456766B1 (es)
JP (2) JP2640568B2 (es)
AT (2) ATE179457T1 (es)
AU (1) AU629920B2 (es)
CA (1) CA2044626C (es)
DE (2) DE69033080T2 (es)
DK (1) DK0456766T3 (es)
ES (1) ES2133269T3 (es)
IL (3) IL93331A (es)
WO (1) WO1990010013A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372438B1 (en) 1988-02-02 2002-04-16 The Regents Of The University Of California Human platelet-derived growth factor receptors
US6110737A (en) * 1988-02-02 2000-08-29 The Regents Of The University Of California Human platelet-derived growth factor receptor, type A
US6228600B1 (en) 1992-07-20 2001-05-08 The United States Of America As Represented By The Department Of Health And Human Services Immunoassays for the alpha platelet-derived growth factor receptor
US5468468A (en) * 1989-02-09 1995-11-21 The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services Method for making a monoclonal antibody, monoclonal antibodies to α PD
US7252929B2 (en) 1989-02-09 2007-08-07 United States Of America, As Represented By The Secretary, Dept Of Health & Human Services Methods for identifying alpha PDGFR agonists and antagonists
EP0584082B1 (en) * 1991-01-31 2000-05-31 Cor Therapeutics, Inc. Domains of extracellular region of human platelet derived growth factor receptor polypeptides
CA2124958C (en) * 1991-12-02 2007-02-13 Vanitha Ramakrishnan Inhibitory immunoglobulin polypeptides to human pdgf beta receptor
US5817310A (en) 1991-12-02 1998-10-06 Cor Therapeutics, Inc. Inhibitory immunoglobulin polypeptides to human PDGF beta receptor
EP0548867A2 (en) * 1991-12-23 1993-06-30 Yeda Research And Development Co. Ltd. Soluble stem cell factor (SFC)-receptor
KR101246504B1 (ko) * 2005-06-17 2013-03-26 임클론 엘엘씨 항－ＰＤＧＦＲα 항체
US20070037224A1 (en) * 2005-08-11 2007-02-15 Hamer Peter J Quantitative assays for PDGFR-beta in body fluids
CL2007002225A1 (es) 2006-08-03 2008-04-18 Astrazeneca Ab Agente de union especifico para un receptor del factor de crecimiento derivado de plaquetas (pdgfr-alfa); molecula de acido nucleico que lo codifica; vector y celula huesped que la comprenden; conjugado que comprende al agente; y uso del agente de un
AU2011274363A1 (en) 2010-07-02 2013-01-24 Medimmune, Llc Antibody formulations
CN102971415B (zh) * 2011-07-01 2016-06-01 株式会社资生堂 血小板源性生长因子-bb产生增强剂、以及包含该增强剂的间充质系干细胞产生促进剂、干细胞稳定剂和真皮再生剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766073A (en) * 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US5094941A (en) 1987-12-31 1992-03-10 Zymogenetics, Inc. Monoclonal antibodies to PDGF
US5567584A (en) * 1988-01-22 1996-10-22 Zymogenetics, Inc. Methods of using biologically active dimerized polypeptide fusions to detect PDGF
US6110737A (en) 1988-02-02 2000-08-29 The Regents Of The University Of California Human platelet-derived growth factor receptor, type A
US6372438B1 (en) * 1988-02-02 2002-04-16 The Regents Of The University Of California Human platelet-derived growth factor receptors
AU607306B2 (en) * 1988-02-02 1991-02-28 Regents Of The University Of California, The Human platelet-derived growth factor receptor
US5100774A (en) 1988-04-22 1992-03-31 The Wistar Institute Of Anatomy & Biology Methods for detecting growth factor receptor expression
JPH04505260A (ja) 1989-05-22 1992-09-17 ザイモジェネティクス，インコーポレイティド ＰＤＧＦα―受容体
US5219727A (en) 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction

Also Published As

Publication number Publication date
IL93331A (en) 2004-06-20
JPH04501063A (ja) 1992-02-27
ATE179457T1 (de) 1999-05-15
IL111322A0 (en) 1994-12-29
DE69033080D1 (de) 1999-06-02
EP0869177A3 (en) 1999-10-20
WO1990010013A1 (en) 1990-09-07
CA2044626A1 (en) 1990-08-10
IL132414A0 (en) 2001-03-19
DE69033080T2 (de) 1999-10-14
JPH0835964A (ja) 1996-02-06
DK0456766T3 (da) 1999-11-08
EP0869177A2 (en) 1998-10-07
AU629920B2 (en) 1992-10-15
EP0456766A1 (en) 1991-11-21
IL93331A0 (en) 1990-11-29
CA2044626C (en) 2001-10-16
JP2640568B2 (ja) 1997-08-13
EP0456766A4 (en) 1992-08-12
EP0456766B1 (en) 1999-04-28
DE69034254D1 (de) 2008-07-17
ATE397659T1 (de) 2008-06-15
JP2826708B2 (ja) 1998-11-18
EP0869177B1 (en) 2008-06-04
US5965359A (en) 1999-10-12
AU5287390A (en) 1990-09-26
US7427671B1 (en) 2008-09-23

Similar Documents

Publication Publication Date Title
ATE319091T1 (de) Diagnose von einheimischer sprue/zöliakie mit hilfe von gliadinepitopen
IL132414A0 (en) Type alpha platelet derived growth factor receptor gene
FI845061A0 (fi) Foerfarande och produkter foer paovisande av humant t-celleukemivirus.
ATE87655T1 (de) Markierer der t-zelle aktivierung.
EP0284587A3 (en) Synthetic peptide antigens for the detection of hiv-1 infection
ATE122394T1 (de) Pankreatische isletzellen-antigene, erhalten durch molekulare klonierung.
DK392387D0 (da) Monoklonalt antistrof til diagnostisk anvendelse og fremgangsmaade til fremstilling af et saadan antistof
DE3881023D1 (de) Proteine, expressionsvektoren, die fuer solche proteine kodierende dna enthalten und zellen, die solche expressionsvektoren enthalten.
IT1241154B (it) Metodo e composizione reagente per la determinazione dell'alanina amminotrasferasi e dell'antigene hbsag in uno stesso campione biologico
DK0418590T3 (da) Antistoffer, fremstilling deraf og anvendelse deraf
NO175639C (no) Peptid, antistoff oppnådd ved hjelp av peptidet, en fremgangsmåte for immunologisk bestemmelse av intakt prokollagen peptid (type III) og anvendelse av peptidet
NO900758L (no) Fremgangsmaate for fremstilling av hybridprotein.
KR880014376A (ko) Hiv 특이 항원 영역의 모노클로날 항체 및 그 용법
EP0293827A3 (en) Assay for leishmaniasis
FI913714A0 (fi) Peptider med foer a 1-mikroglobulin karakteristiska antigeniska determinanter.
ATE87941T1 (de) Monoklonaler antikoerper gegen ein p21-bezuegliches dodekapeptid des ras-onkogens.
FR2663034B1 (fr) Peptides de l'antigene sm-d et leur utilisation notamment pour le diagnostic du lupus erythemateux dissemine.
ATE183777T1 (de) Intrazelluläres antigen in einer subpopulation von cd8+t-lymphozyten und ein monoklonaler antikörper spezifisch dafür
PT93764A (pt) Processo para a preparacao de moleculas comportando pelo menos uma sequencia peptidica portadora de um, ou varios, epitopo(s) caracteristico(s) de uma proteina produzida por "p.falciparum" ao nivel do estadio esporozoito e nos hepatocitos
Iwaguchi et al. Analysis of electrophoretic mobility histogram of mouse thymocytes during tumour development
FI102381B1 (fi) Epstein-Barrin viruksen tuma-antigeeniin (EBNA) liittyviä synteettisiä polypeptidejä ja menetelmä anti-EBNA-vasta-aineiden tunnistamiseksi kudosnäytteessä
RU96119723A (ru) Способ выявления т-зависимого иммунодефицита
DK418587A (da) Fremgangsmaade til analyse af immunogene peptidsekvenser
Shenderovich et al. Use of ELISA for the detection and differentiation of influenza A, B, and C viruses.
SE8701294L (sv) Hiv-peptid

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 456766

Country of ref document: ES