ES2133401T3 - Utilizacion de farmacos cardiotonicos e inhibidores de sintesis del oxido nitrico para mitigar la hipotension patologica. - Google Patents

Utilizacion de farmacos cardiotonicos e inhibidores de sintesis del oxido nitrico para mitigar la hipotension patologica.

Info

Publication number
ES2133401T3
ES2133401T3 ES93914126T ES93914126T ES2133401T3 ES 2133401 T3 ES2133401 T3 ES 2133401T3 ES 93914126 T ES93914126 T ES 93914126T ES 93914126 T ES93914126 T ES 93914126T ES 2133401 T3 ES2133401 T3 ES 2133401T3
Authority
ES
Spain
Prior art keywords
nitric oxide
pharmaces
cardiotonic
hypotension
pathologic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93914126T
Other languages
English (en)
Inventor
Robert G Kilbourn
Steven S Gross
Owen W Griffith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
University of Texas System
University of Texas at Austin
Original Assignee
Cornell Research Foundation Inc
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Research Foundation Inc, University of Texas System, University of Texas at Austin filed Critical Cornell Research Foundation Inc
Application granted granted Critical
Publication of ES2133401T3 publication Critical patent/ES2133401T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

EL PRESENTE INVENTO SE REFIERE A UN METODO PARA LA PROFILAXIS O TRATAMIENTO DE UN ANIMAL CON HIPOTENSION SISTEMICA INDUCIDA POR UNA ENDOTOXINA Y/O UN MODIFICADOR DE RESPUESTA BIOLOGICA TAL COMO LAS CITOQUINAS, IFN, TFN, IL - 1 O IL - 2 Y SIMILARES. DICHO METODO IMPLICA ADMINISTRAR, PREFERIBLEMENTE INTRAVASCULARMENTE, UNA CANTIDAD EFECTIVA TERAPEUTICAMENTE DE DOBUTAMINA Y UN INHIBIDOR DE FORMACION DE OXIDO NITRICO DE ARGININA. AUNQUE ES PREFERIBLE QUE LA ADMINISTRACION SEA INTRAVASCULAR, SE CONTEMPLA QUE PUEDAN RESULTAR UTILES, POR EJEMPLO, OTRAS VIAS DE ADMINISTRACION PARENTERALES TALES COMO INTRAPERITONEAL, INTRAMUSCULAR O INYECCION SUBCUTANEA. LA ADMINISTRACION ENTERAL O TOPICA DE ANALOGOS DE ARGININA SE PUEDE MOSTRAR TAMBIEN BENEFICIOSA BAJO CIERTAS CONDICIONES CLINICAS.
ES93914126T 1992-05-29 1993-05-25 Utilizacion de farmacos cardiotonicos e inhibidores de sintesis del oxido nitrico para mitigar la hipotension patologica. Expired - Lifetime ES2133401T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/890,430 US5312835A (en) 1989-09-13 1992-05-29 Use of cardiotonic drugs and inhibitors of nitric oxide synthesis to alleviate pathologic hypotension

Publications (1)

Publication Number Publication Date
ES2133401T3 true ES2133401T3 (es) 1999-09-16

Family

ID=25396669

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93914126T Expired - Lifetime ES2133401T3 (es) 1992-05-29 1993-05-25 Utilizacion de farmacos cardiotonicos e inhibidores de sintesis del oxido nitrico para mitigar la hipotension patologica.

Country Status (9)

Country Link
US (2) US5312835A (es)
EP (1) EP0669824B1 (es)
JP (1) JPH08501069A (es)
AT (1) ATE178486T1 (es)
AU (1) AU664295B2 (es)
CA (1) CA2136205A1 (es)
DE (1) DE69324374T2 (es)
ES (1) ES2133401T3 (es)
WO (1) WO1993024122A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5312835A (en) * 1989-09-13 1994-05-17 Board Of Regents, The University Of Texas System Use of cardiotonic drugs and inhibitors of nitric oxide synthesis to alleviate pathologic hypotension
US5612310A (en) * 1993-05-24 1997-03-18 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5554638A (en) * 1993-05-24 1996-09-10 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5695761A (en) * 1993-12-23 1997-12-09 Rutgers University Suppression of nitric oxide production by osteopontin
JP2002509555A (ja) * 1998-04-06 2002-03-26 藤沢薬品工業株式会社 新規用途
GB9810299D0 (en) * 1998-05-15 1998-07-15 Glaxo Group Ltd Use of nitric oxide synthase inhibitors
WO2003099011A1 (en) * 2002-05-28 2003-12-04 Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Cardiac glycosides to treat cystic fibrosis and other il-8 dependent disorders
CN100389768C (zh) * 2004-08-25 2008-05-28 浙江震元制药有限公司 米力农注射用组合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1127322B (it) * 1979-12-28 1986-05-21 Italfarmaco Spa Composizioni farmaceutiche con esaltazione dell'attivita' terapeutica di cortisonici
US5059712A (en) * 1989-09-13 1991-10-22 Cornell Research Foundation, Inc. Isolating aminoarginine and use to block nitric oxide formation in body
US5312835A (en) * 1989-09-13 1994-05-17 Board Of Regents, The University Of Texas System Use of cardiotonic drugs and inhibitors of nitric oxide synthesis to alleviate pathologic hypotension
US5028627A (en) * 1989-09-13 1991-07-02 Cornell Research Foundation, Inc. Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor

Also Published As

Publication number Publication date
AU664295B2 (en) 1995-11-09
EP0669824B1 (en) 1999-04-07
WO1993024122A1 (en) 1993-12-09
EP0669824A1 (en) 1995-09-06
DE69324374D1 (de) 1999-05-12
DE69324374T2 (de) 1999-11-04
EP0669824A4 (en) 1995-07-25
JPH08501069A (ja) 1996-02-06
US5776979A (en) 1998-07-07
US5312835A (en) 1994-05-17
ATE178486T1 (de) 1999-04-15
AU4389793A (en) 1993-12-30
CA2136205A1 (en) 1993-12-09

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