ES2133454T3 - Mezcla efervescente con sales alcalinas o lisinatos de principios activos acidos, insolubles o dificilmente solubles. - Google Patents
Mezcla efervescente con sales alcalinas o lisinatos de principios activos acidos, insolubles o dificilmente solubles.Info
- Publication number
- ES2133454T3 ES2133454T3 ES94113877T ES94113877T ES2133454T3 ES 2133454 T3 ES2133454 T3 ES 2133454T3 ES 94113877 T ES94113877 T ES 94113877T ES 94113877 T ES94113877 T ES 94113877T ES 2133454 T3 ES2133454 T3 ES 2133454T3
- Authority
- ES
- Spain
- Prior art keywords
- lysinates
- effervescent
- insoluble
- mix
- hardly soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title 1
- 159000000011 group IA salts Chemical class 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 239000013078 crystal Substances 0.000 abstract 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 239000001509 sodium citrate Substances 0.000 abstract 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/82—Acid flavourants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
Abstract
LA MEZCLA EFERVESCENTE CONTIENE AL MENOS UNA SUSTANCIA ACTIVA FARMACEUTICA ACIDA, INSOLUBLE O DIFICILMENTE SOLUBLE EN FORMA DE SU SAL ALCALINA SOLUBLE O LISINATO, QUE EN UNA MEZCLA INTIMA ESTA PRESENTE CON EL COMPONENTE ALCALINO Y CON PREFERENCIA ENVUELTO CON LAS PARTICULAS DEL COMPONENTE ALCALINO DEL SISTEMA EFERVESCENTE, POR EJEMPLO BICARBONATO DE SODIO Y/O CARBONATO DE SODIO. AMBOS COMPONENTES PUEDEN TAMBIEN ESTAR PRESENTES DE FORMA PULVERIZADA FINA CON LA AYUDA DE UN AGLOMERANTE COMO GRANULADO. LA MEZCLA EFERVESCENTE CONTIENE ESPECIALMENTE SOBRE 100 PARTES DE SUSTANCIA ACTIVA AL MENOS 0,5, CON PREFERENCIA DESDE 1 HASTA 3 PARTES DE UN SURFACTANTE, ESPECIALMENTE DIOCTIL SULFOSUCINATO, Y/O AL MENOS 1, CON PREFERENCIA 3 HASTA 5 PARTES DE UN MEDIO AGLOMERANTE O MEDIO AUXILIAR DE SUSPENSION, EN PARTICULAR POLIVINIL PIRROLIDON. EL COMPONENTE ACIDO DEL SISTEMA EFERVESCENTE ESTA PASIVADO SUPERFICIALMENTE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH265293 | 1993-09-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2133454T3 true ES2133454T3 (es) | 1999-09-16 |
Family
ID=4238568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94113877T Expired - Lifetime ES2133454T3 (es) | 1993-09-07 | 1994-09-05 | Mezcla efervescente con sales alcalinas o lisinatos de principios activos acidos, insolubles o dificilmente solubles. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5593693A (es) |
| EP (2) | EP0642784B1 (es) |
| JP (1) | JPH07223937A (es) |
| CN (1) | CN1096279C (es) |
| AT (2) | ATE219762T1 (es) |
| CA (1) | CA2131515C (es) |
| DE (3) | DE59410143D1 (es) |
| DK (1) | DK0642784T3 (es) |
| ES (1) | ES2133454T3 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1283029B1 (it) * | 1996-05-17 | 1998-04-03 | Resa Farma | Composizioni farmaceutiche a base di diclofenac |
| US7687542B2 (en) | 1996-05-17 | 2010-03-30 | Kowa Pharmaeuticals America, Inc. | Rapidly bioavailable tablet and capsule formulations of diclofenac |
| US6974595B1 (en) | 1996-05-17 | 2005-12-13 | Proethic Pharmaceuticals, Inc. | Pharmaceutical compositions based on Diclofenae |
| DE59808063D1 (de) * | 1998-06-03 | 2003-05-28 | Gergely Dr & Co | Mit Alkali- bzw. Erdalkali-Ionen dotierte Zitronensäure |
| US6121215A (en) * | 1999-08-27 | 2000-09-19 | Phyzz, Inc. | Foaming effervescent bath product |
| US6432450B1 (en) | 1999-09-09 | 2002-08-13 | Gerhard Gergely | Effervescent granules with delayed effervescent effect |
| EP1082957B1 (de) * | 1999-09-09 | 2003-04-23 | Dr. Gergely & Co. | Brausegranulat mit verzögerter Brausewirkung |
| FR2811531A1 (fr) * | 2000-07-12 | 2002-01-18 | Bionatec | Produit pour le maintien d'objets decoratifs, procede de fabrication et d'utilisation dudit produit |
| JP2005521497A (ja) * | 2002-03-25 | 2005-07-21 | ワシントン・ユニバーシティ | キメラ膵臓 |
| WO2004050068A1 (en) * | 2002-11-29 | 2004-06-17 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base |
| EP3216445A1 (en) * | 2004-05-28 | 2017-09-13 | Imaginot Pty Ltd. | Oral therapeutic compound delivery system |
| US8216610B2 (en) * | 2004-05-28 | 2012-07-10 | Imaginot Pty Ltd. | Oral paracetamol formulations |
| JO3352B1 (ar) | 2005-06-17 | 2019-03-13 | Apr Applied Pharma Res Sa | صيغ دايكلوفيناك وطرق استخدامه |
| CA2629904C (en) * | 2005-11-28 | 2018-07-10 | Imaginot Pty Ltd. | Oral therapeutic compound delivery system |
| US7939561B2 (en) | 2006-02-07 | 2011-05-10 | Apr Applied Pharma Research S.A. | Blister packaging for acute pain regimens |
| US7700125B2 (en) | 2006-02-07 | 2010-04-20 | Kowa Pharmaceuticals America, Inc. | Moisture resistant container systems for rapidly bioavailable dosage forms |
| BRPI0714423B1 (pt) | 2006-07-12 | 2016-10-04 | Purac Biochem Bv | partícula grau alimentício revestida com ácido parcialmente neutralizado, produto alimentício ou bebida, método para preparação da referida partícula e uso de ácido policarboxílico |
| WO2013052019A1 (en) * | 2011-08-19 | 2013-04-11 | Mahmut Bilgic | Production method for effervescent formulations comprising diclofenac |
| WO2013109222A1 (en) * | 2012-01-18 | 2013-07-25 | Mahmut Bilgic | Formulations comprising diclofenac as the active agent |
| EP3037387A1 (en) * | 2014-12-22 | 2016-06-29 | Solvay SA | Alkali metal bicarbonate particles with exceptional flowability |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3165572D1 (en) * | 1981-10-06 | 1984-09-20 | Gergely Gerhard | Process for manufacturing effervescent granules which may be transformed, when required, into effervescent tablets |
| US4678661A (en) * | 1983-09-28 | 1987-07-07 | Gerhard Gergely | Effervescent composition and method of making same |
| JPS6092378A (ja) * | 1983-09-28 | 1985-05-23 | ゲルハルト・ゲルゲリー | 起泡剤およびその製造方法 |
| DE3440288C2 (de) * | 1984-11-05 | 1987-03-12 | Gergely, Gerhard, Dr.-Ing., Wien | Pharmazeutische Zubereitung mit einem Gehalt an Ibuprofen sowie Verfahren zu ihrer Herstellung |
| DE3627475A1 (de) | 1986-06-26 | 1988-01-14 | Gergely Gerhard | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung |
| DE3838431A1 (de) | 1988-11-12 | 1990-05-17 | Bayer Ag | Ibuprofen-brausezubereitungen |
| US5064656A (en) * | 1989-11-14 | 1991-11-12 | Dr. Gergely & Co. | Uncoated pharmaceutical reaction tablet |
| IT1246350B (it) * | 1990-07-11 | 1994-11-17 | Eurand Int | Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili |
| CA2112663C (en) * | 1991-07-01 | 2002-04-23 | Thomas Gergely | Effervescent systems using reaction doping agents |
| DE9300886U1 (de) * | 1993-01-22 | 1993-05-27 | Ebinger, Klaus, 5000 Köln | Stabförmige Magnetometer-Sonde |
-
1994
- 1994-09-05 AT AT98110087T patent/ATE219762T1/de active
- 1994-09-05 EP EP94113877A patent/EP0642784B1/de not_active Expired - Lifetime
- 1994-09-05 DK DK94113877T patent/DK0642784T3/da active
- 1994-09-05 DE DE59410143T patent/DE59410143D1/de not_active Expired - Lifetime
- 1994-09-05 AT AT94113877T patent/ATE180164T1/de active
- 1994-09-05 ES ES94113877T patent/ES2133454T3/es not_active Expired - Lifetime
- 1994-09-05 DE DE9422239U patent/DE9422239U1/de not_active Expired - Lifetime
- 1994-09-05 DE DE59408273T patent/DE59408273D1/de not_active Expired - Lifetime
- 1994-09-05 EP EP98110087A patent/EP0867426B1/de not_active Expired - Lifetime
- 1994-09-06 CA CA002131515A patent/CA2131515C/en not_active Expired - Lifetime
- 1994-09-07 CN CN94113873A patent/CN1096279C/zh not_active Expired - Fee Related
- 1994-09-07 US US08/301,970 patent/US5593693A/en not_active Expired - Lifetime
- 1994-09-07 JP JP6213623A patent/JPH07223937A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0867426A2 (de) | 1998-09-30 |
| ATE180164T1 (de) | 1999-06-15 |
| ATE219762T1 (de) | 2002-07-15 |
| EP0867426B1 (de) | 2002-06-26 |
| CN1107366A (zh) | 1995-08-30 |
| DK0642784T3 (da) | 1999-11-22 |
| CA2131515C (en) | 2006-08-29 |
| DE59408273D1 (de) | 1999-06-24 |
| JPH07223937A (ja) | 1995-08-22 |
| EP0642784A1 (de) | 1995-03-15 |
| CN1096279C (zh) | 2002-12-18 |
| DE9422239U1 (de) | 1999-05-06 |
| EP0642784B1 (de) | 1999-05-19 |
| US5593693A (en) | 1997-01-14 |
| EP0867426A3 (en) | 1998-11-11 |
| DE59410143D1 (de) | 2002-08-01 |
| CA2131515A1 (en) | 1995-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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