ES2135564T3 - Procedimiento para la obtencion de un adhesivo biologico que comprende fibrinogeno, factor xiii y fibronectina. - Google Patents

Procedimiento para la obtencion de un adhesivo biologico que comprende fibrinogeno, factor xiii y fibronectina.

Info

Publication number
ES2135564T3
ES2135564T3 ES94908221T ES94908221T ES2135564T3 ES 2135564 T3 ES2135564 T3 ES 2135564T3 ES 94908221 T ES94908221 T ES 94908221T ES 94908221 T ES94908221 T ES 94908221T ES 2135564 T3 ES2135564 T3 ES 2135564T3
Authority
ES
Spain
Prior art keywords
proteins
fibronectin
factor xiii
biological adhesive
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94908221T
Other languages
English (en)
Inventor
Trung Bui-Khac
Lise Lavoie
St Picq Dominique Michel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HAEMACURE CORP CORP HAEMACURE
Haemacure Corp Canada
Original Assignee
HAEMACURE CORP CORP HAEMACURE
Haemacure Corp Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25683079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2135564(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by HAEMACURE CORP CORP HAEMACURE, Haemacure Corp Canada filed Critical HAEMACURE CORP CORP HAEMACURE
Application granted granted Critical
Publication of ES2135564T3 publication Critical patent/ES2135564T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCESO PARA FABRICAR UN CONCENTRADO DE PROTEINAS DE COAGULACION EMPEZANDO CON PLASMA DE HUMANO O ANIMAL INTEGRO. ESTE CONCENTRADO SE USA COMO UN ADHESIVO BIOLOGICO CUANDO SE MEZCLA EXTEMPORANEAMENTE CON TROMBINA. LAS PROTEINAS CONCENTRADAS INCLUYEN PRINCIPALMENTE PARTE FIBRINOGENO, UN FACTOR ESTABILIZADOR DE FIBRINA (FACTOR XIII) Y FIBRONECTINA. EL PROCESO PRESENTADO TIENE LA VENTAJA DE SER DE CORTA EJECUCION, MIENTRAS QUE SUMINISTRA UNA PRODUCCION EXCELENTE DE PROTEINAS COAGULABLES. NINGUN INHIBIDOR DE PROTEASA TIENE QUE SER AÑADIDO DURANTE EL PROCESO. EL PROCESO IMPLICA ETAPAS DE SEPARACION POR DESALADO EN PRESENCIA DE ACIDO AMINO-6 HEXANOICO QUE EVITA LA COPRECIPITACION DE PLASMINOGENO CON LAS PROTEINAS COAGULABLES DESEADAS. LAS PROTEINAS ASI OBTENIDAS SON MUY ESTABLES DESPUES DE SU RECONSTITUCION EN AGUA DURANTE AL MENOS 24 HORAS A TEMPERATURA AMBIENTE O CORPORAL. DESPUES SU MEZCLA CON TROMBINA Y CALCIO, EL ADHESIVO MUESTRA EXCELENTE RESISTENCIA YBIOCOMPATIBILIDAD
ES94908221T 1993-02-23 1994-02-28 Procedimiento para la obtencion de un adhesivo biologico que comprende fibrinogeno, factor xiii y fibronectina. Expired - Lifetime ES2135564T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/021,302 US5395923A (en) 1993-02-23 1993-02-23 Process for the obtention of a biological adhesive made of concentrated coagulation factors by "salting-out"
PCT/CA1994/000105 WO1995023167A1 (en) 1993-02-23 1994-02-28 Process for the obtention of a biological adhesive comprising fibrinogen, factor xiii and fibronectin

Publications (1)

Publication Number Publication Date
ES2135564T3 true ES2135564T3 (es) 1999-11-01

Family

ID=25683079

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94908221T Expired - Lifetime ES2135564T3 (es) 1993-02-23 1994-02-28 Procedimiento para la obtencion de un adhesivo biologico que comprende fibrinogeno, factor xiii y fibronectina.

Country Status (12)

Country Link
US (1) US5395923A (es)
EP (1) EP0748337B1 (es)
JP (1) JP3492694B2 (es)
AT (1) ATE181738T1 (es)
AU (1) AU678439B2 (es)
CA (1) CA2113660C (es)
DE (1) DE69419324T2 (es)
DK (1) DK0748337T3 (es)
ES (1) ES2135564T3 (es)
NO (1) NO317699B1 (es)
RU (1) RU2130946C1 (es)
WO (1) WO1995023167A1 (es)

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Also Published As

Publication number Publication date
NO963602D0 (no) 1996-08-28
AU678439B2 (en) 1997-05-29
EP0748337B1 (en) 1999-06-30
DE69419324T2 (de) 2000-03-02
US5395923A (en) 1995-03-07
DE69419324D1 (de) 1999-08-05
EP0748337A1 (en) 1996-12-18
AU6151594A (en) 1995-09-11
NO963602L (no) 1996-10-17
JP3492694B2 (ja) 2004-02-03
CA2113660C (en) 2000-05-16
JPH09509183A (ja) 1997-09-16
WO1995023167A1 (en) 1995-08-31
RU2130946C1 (ru) 1999-05-27
NO317699B1 (no) 2004-12-06
CA2113660A1 (en) 1994-08-24
DK0748337T3 (da) 2000-01-17
ATE181738T1 (de) 1999-07-15

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