ES2136157T3 - Producto granular o comprimido que contiene un sistema efervescente y una sustancia farmaceutica activa, asi como un procedimiento para su preparacion. - Google Patents
Producto granular o comprimido que contiene un sistema efervescente y una sustancia farmaceutica activa, asi como un procedimiento para su preparacion.Info
- Publication number
- ES2136157T3 ES2136157T3 ES94203112T ES94203112T ES2136157T3 ES 2136157 T3 ES2136157 T3 ES 2136157T3 ES 94203112 T ES94203112 T ES 94203112T ES 94203112 T ES94203112 T ES 94203112T ES 2136157 T3 ES2136157 T3 ES 2136157T3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- granular
- effervescent system
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 abstract 1
- 229940069428 antacid Drugs 0.000 abstract 1
- 239000003159 antacid agent Substances 0.000 abstract 1
- 230000001458 anti-acid effect Effects 0.000 abstract 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 abstract 1
- 235000013734 beta-carotene Nutrition 0.000 abstract 1
- 239000011648 beta-carotene Substances 0.000 abstract 1
- 229960002747 betacarotene Drugs 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 229960001380 cimetidine Drugs 0.000 abstract 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 abstract 1
- DCSUBABJRXZOMT-IRLDBZIGSA-N cisapride Chemical compound C([C@@H]([C@@H](CC1)NC(=O)C=2C(=CC(N)=C(Cl)C=2)OC)OC)N1CCCOC1=CC=C(F)C=C1 DCSUBABJRXZOMT-IRLDBZIGSA-N 0.000 abstract 1
- 229960005132 cisapride Drugs 0.000 abstract 1
- DCSUBABJRXZOMT-UHFFFAOYSA-N cisapride Natural products C1CC(NC(=O)C=2C(=CC(N)=C(Cl)C=2)OC)C(OC)CN1CCCOC1=CC=C(F)C=C1 DCSUBABJRXZOMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- -1 for example Substances 0.000 abstract 1
- 239000000416 hydrocolloid Substances 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 abstract 1
- 229960000620 ranitidine Drugs 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229920003169 water-soluble polymer Polymers 0.000 abstract 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
DE ACUERDO CON ESTA INVENCION SE PREVE UN PRODUCTO GRANULAR CON UN SISTEMA EFERVESCENTE QUE COMPRENDE SUSTANCIAS FARMACEUTICAMENTE ACTIVAS SENSIBLE AL ACIDO, TAL COMO, POR EJEMPLO BETACAROTENO, CIMETIDINA, RANTIDINA O CISAPRIDA, QUE ES ESPECIALMENTE UTIL PARA PREVENIR LA ACCION ANTIACIDO, QUE TIENE UNA CAPACIDAD DE ENLACE DE ACIDO POR DEBAJO DE APROXIMADAMENTE 5 MEQ, EN UN PESO DE APROXIMADAMENTE 1.6 A APROXIMADAMENTE 2.3 GRAMOS. LOS GRANOS EFERVESCENTES ESTAN HECHOS DE CRISTALES PORTADORES DE LA MENOS UN ACIDO ORGANICO COMESTIBLE SOLIDO, PREFERENTEMENTE ACIDO CITRICO, Y ESTAN PRESENTES COMO UN PRODUCTO GRANULAR, SEPARADOS DE LA SUSTANCIA FARMACEUTICAMENTE ACTIVA, Y ESTAN REVESTIDOS CON AL MENOS UNA CAPA DE UNA SUSTANCIA NEUTRA HIDROSOLUBLE QUE ES SUSCEPTIBLE DE LLEVAR APROXIMADAMENTE UNA DEPRESION DE PUNTO DE FUSION DE LOS GRANOS ACIDOS EN SU SUPERFICIE, TAL COMO, POR EJEMPLO, UN POLIMERO HIDROSOLUBLE, UN MAYOR ALCOHOL, UN CARBOHIDRATO Y/O HIDROCOLOIDE. UN SEGUNDO REVESTIMIENTO QUE CONTIENEN AL MENOS UNA PARTE DEL CARBONATO ALCALINOTERROSO Y/O ALCALINO O BICARBONATO PREVISTA PARA LA DOSIFICACION TOTAL.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4406641 | 1994-03-01 | ||
| CH87394 | 1994-03-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2136157T3 true ES2136157T3 (es) | 1999-11-16 |
Family
ID=25685969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94203112T Expired - Lifetime ES2136157T3 (es) | 1994-03-01 | 1994-10-26 | Producto granular o comprimido que contiene un sistema efervescente y una sustancia farmaceutica activa, asi como un procedimiento para su preparacion. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0670160B1 (es) |
| KR (1) | KR100358211B1 (es) |
| AT (1) | ATE182073T1 (es) |
| DE (1) | DE69419492T2 (es) |
| DK (1) | DK0670160T3 (es) |
| ES (1) | ES2136157T3 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824339A (en) * | 1995-09-08 | 1998-10-20 | Takeda Chemical Industries, Ltd | Effervescent composition and its production |
| US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| DE69713948D1 (de) * | 1996-04-23 | 2002-08-22 | Janssen Pharmaceutica Nv | Rasch-freisetzende pH-unabhängige feste Dosisformen enthaltend Cisaprid |
| EP0803251B1 (en) * | 1996-04-23 | 2002-07-17 | Janssen Pharmaceutica N.V. | Immediate release pH-independent solid dosage form of cisapride |
| US20030087005A1 (en) | 1996-10-10 | 2003-05-08 | Peter Baron | Drink flavouring straw |
| AUPS270602A0 (en) | 2002-05-31 | 2002-06-20 | Baron, Peter | Drink flavouring straw |
| US5807580A (en) * | 1996-10-30 | 1998-09-15 | Mcneil-Ppc, Inc. | Film coated tablet compositions having enhanced disintegration characteristics |
| FR2758265B1 (fr) * | 1997-01-16 | 2004-08-13 | Pf Medicament | Microspheres effervescentes et leur procede de fabrication |
| US6534016B1 (en) | 1997-04-30 | 2003-03-18 | Richmond Cohen | Additive preparation and method of use thereof |
| US6225123B1 (en) | 1997-04-30 | 2001-05-01 | Becton Dickinson And Company | Additive preparation and method of use thereof |
| AU2002300487B2 (en) * | 1997-04-30 | 2006-04-27 | Becton, Dickinson And Company | Additive preparation and method of use thereof |
| CA2292628A1 (en) * | 1997-06-11 | 1998-12-17 | Janssen Pharmaceutica, N.V. | Immediate release ph-independent solid dosage form of (+)- or (-)-cisapride |
| SE9702533D0 (sv) | 1997-07-01 | 1997-07-01 | Astra Ab | New oral formulation |
| ATE241957T1 (de) * | 1997-09-16 | 2003-06-15 | Gergely Dr & Co | Brausezubereitung und verfahren zu ihrer herstellung |
| CA2305179A1 (en) * | 1997-09-30 | 1999-04-08 | Daiichi Pharmaceutical Co., Ltd. | Oral administration preparation |
| DE69817189T2 (de) * | 1998-11-23 | 2004-06-17 | E-Pharma Trento S.P.A., Trento Ravina | Verfahren zur Herstellung eines Brausegranulats |
| US6264984B1 (en) | 1999-12-06 | 2001-07-24 | Bristol-Myers Squibb Company | Effervescent histamine H2 antagonist composition |
| AU2003251152A1 (en) * | 2002-07-03 | 2004-01-23 | Shannon Biotechnology Ltd | Pharmaceutical formulations for preparing drink products |
| US7588696B2 (en) | 2003-06-12 | 2009-09-15 | Cargill, Incorporated | Antimicrobial water softener salt and solutions |
| US7090882B2 (en) | 2003-06-12 | 2006-08-15 | Cargill, Incorporated | Antimicrobial salt solutions for food safety applications |
| US7658959B2 (en) | 2003-06-12 | 2010-02-09 | Cargill, Incorporated | Antimicrobial salt solutions for food safety applications |
| US7883732B2 (en) | 2003-06-12 | 2011-02-08 | Cargill, Incorporated | Antimicrobial salt solutions for cheese processing applications |
| US8486472B2 (en) | 2006-01-18 | 2013-07-16 | Cargill, Incorporated | Antimicrobial salt solutions for food safety applications |
| AR060029A1 (es) | 2006-03-02 | 2008-05-21 | Unistraw Patent Holdings Ltd | Pajilla para beber adaptada para acondicionar progresivamente un ingrediente activo y metodo de fabricar dicha pajilla |
| BRPI0602825A2 (pt) * | 2006-06-23 | 2012-04-24 | Rhodia Br Ltda | formulação de pó efervescente auto-refrigerante para bebidas e uso de formulação em pó efervescente |
| WO2013043142A1 (en) * | 2011-08-08 | 2013-03-28 | Mahmut Bilgic | Production method for pharmaceutical formulations comprising an isoflavone |
| EP2788289B1 (de) * | 2011-12-09 | 2019-07-31 | Merck Patent GmbH | Porenarmes, wasserfreies natriumcarbonat |
| KR101591319B1 (ko) * | 2013-12-03 | 2016-02-18 | 에프엔바이오 주식회사 | 홍삼 발포정의 제조방법 |
| CN113975259B (zh) * | 2021-09-14 | 2023-05-09 | 南京海纳医药科技股份有限公司 | 一种盐酸氨溴索复方泡腾片及其制备方法 |
| CN114159399A (zh) * | 2021-11-11 | 2022-03-11 | 大连双迪科技股份有限公司 | 一种口腔微泡含片及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1039170A (en) * | 1969-02-24 | 1971-07-22 | Abbott Laboratories | Tableting medium |
| US4704269A (en) * | 1985-06-11 | 1987-11-03 | Hudson Pharmaceutical Corporation | Effervescent antacid and analgesic compositions |
| CA2023493C (en) * | 1989-08-31 | 2000-01-04 | Masami Moroi | Composition for foaming preparation |
| US5415870A (en) * | 1991-07-01 | 1995-05-16 | Gerhard Gergely | Effervescent systems using reaction doping agents |
-
1994
- 1994-10-26 EP EP94203112A patent/EP0670160B1/en not_active Expired - Lifetime
- 1994-10-26 DK DK94203112T patent/DK0670160T3/da not_active Application Discontinuation
- 1994-10-26 ES ES94203112T patent/ES2136157T3/es not_active Expired - Lifetime
- 1994-10-26 AT AT94203112T patent/ATE182073T1/de active
- 1994-10-26 DE DE69419492T patent/DE69419492T2/de not_active Expired - Lifetime
-
1995
- 1995-02-23 KR KR1019960704598A patent/KR100358211B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK0670160T3 (da) | 2000-02-14 |
| ATE182073T1 (de) | 1999-07-15 |
| DE69419492D1 (de) | 1999-08-19 |
| EP0670160B1 (en) | 1999-07-14 |
| EP0670160A1 (en) | 1995-09-06 |
| DE69419492T2 (de) | 2000-02-03 |
| KR100358211B1 (ko) | 2003-02-06 |
| KR970701038A (ko) | 1997-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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