ES2137623T3 - Vehiculos de transporte para macromoleculas. - Google Patents

Vehiculos de transporte para macromoleculas.

Info

Publication number
ES2137623T3
ES2137623T3 ES96202095T ES96202095T ES2137623T3 ES 2137623 T3 ES2137623 T3 ES 2137623T3 ES 96202095 T ES96202095 T ES 96202095T ES 96202095 T ES96202095 T ES 96202095T ES 2137623 T3 ES2137623 T3 ES 2137623T3
Authority
ES
Spain
Prior art keywords
vesicles
macromolecules
transport vehicles
cells
new compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96202095T
Other languages
English (en)
Inventor
Jan Bernard Frederik Engberts
Anno Wagenaar
Dirk Hoekstra
Der Woude Irene Van
Marcel Herman Jozef Ruiters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STICHTING SCHEIKUNDIG ONDERZOE
STICHTING TECH WETENSCHAPP
Stichting voor de Technische Wetenschappen STW
Rijksuniversiteit Groningen
Original Assignee
STICHTING SCHEIKUNDIG ONDERZOE
STICHTING TECH WETENSCHAPP
Stichting voor de Technische Wetenschappen STW
Rijksuniversiteit Groningen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by STICHTING SCHEIKUNDIG ONDERZOE, STICHTING TECH WETENSCHAPP, Stichting voor de Technische Wetenschappen STW, Rijksuniversiteit Groningen filed Critical STICHTING SCHEIKUNDIG ONDERZOE
Application granted granted Critical
Publication of ES2137623T3 publication Critical patent/ES2137623T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/20—Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Treatment Of Sludge (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS COMPUESTOS CON LA FORMULA GENERAL (I) PARA USAR COMO UNA HERRAMIENTA PARA INTRODUCIR MACROMOLECULAS EN LAS CELULAS. EL DESCUBRIMIENTO ADEMAS SE REFIERE A COMPOSICIONES PARA INTRODUCIR MACROMOLECULAS EN CELULAS, QUE CONTIENEN VESICULAS FORMADAS POR AL MENOS UN COMPUESTO EN UN DISOLVENTE. LA MACROMOLECULA PUEDE SER INCORPORADA EN LAS VESICULAS Y/O UNIDA A LAS VESICULAS U OTRO AGREGADO DE LOS NUEVOS COMPUESTOS. EN UNA VERSION PREFERIDA AL MENOS UNA MOLECULA DIANIZADORA, POR EJEMPLO UN (MARCADO) ANTICUERPO, PUEDE ADEMAS SER UNIDO A LAS VESICULAS.
ES96202095T 1995-07-25 1996-07-24 Vehiculos de transporte para macromoleculas. Expired - Lifetime ES2137623T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL1000884A NL1000884C2 (nl) 1995-07-25 1995-07-25 Transportvehikels voor macromoleculen.

Publications (1)

Publication Number Publication Date
ES2137623T3 true ES2137623T3 (es) 1999-12-16

Family

ID=19761371

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96202095T Expired - Lifetime ES2137623T3 (es) 1995-07-25 1996-07-24 Vehiculos de transporte para macromoleculas.

Country Status (10)

Country Link
US (1) US5853694A (es)
EP (1) EP0755924B1 (es)
JP (1) JP4771564B2 (es)
AT (1) ATE181065T1 (es)
CA (1) CA2181841C (es)
DE (1) DE69602809T2 (es)
DK (1) DK0755924T3 (es)
ES (1) ES2137623T3 (es)
GR (1) GR3031200T3 (es)
NL (1) NL1000884C2 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990025725A (ko) * 1997-09-13 1999-04-06 윤종용 파장 분할 다중 통신용 광섬유 및 그 제조 방법
US6376471B1 (en) * 1997-10-10 2002-04-23 Johns Hopkins University Gene delivery compositions and methods
US6936469B2 (en) 2001-03-22 2005-08-30 Chromos Molecular Systems Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US20030186390A1 (en) * 2001-03-22 2003-10-02 De Jong Gary Methods for delivering nucleic acid molecules into cells and assessment thereof
NZ527972A (en) * 2001-03-22 2006-04-28 Chromos Molecular Systems Inc Methods for delivering nucleic acid molecules into cells and assessment thereof
US7294511B2 (en) 2001-03-22 2007-11-13 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
EP1254896A1 (en) * 2001-05-03 2002-11-06 Applied NanoSystems B.V. Cationic amphiphiles, preparation and method for transfection
WO2003093469A2 (en) * 2002-05-01 2003-11-13 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US7330851B2 (en) * 2003-08-18 2008-02-12 Eaglehawk, Limited Data security through dissembly of data elements or connections between elements
NL1027311C2 (nl) * 2004-10-21 2006-05-01 Synvolux Ip B V Vehikel voor transport van een DNA-modificerend enzym naar een genoom.
NL1027479C2 (nl) * 2004-10-21 2006-05-01 Synvolux Ip B V Bescherming van biologisch actieve moleculen met behulp van amphifielen.
AU2008295666B2 (en) * 2007-09-07 2013-05-16 Synvolux Ip B.V. Improved liposomes and uses thereof
GB0724253D0 (en) 2007-12-12 2008-01-30 Fermentas Uab Transfection reagent
DE102008032594A1 (de) 2008-07-11 2010-01-14 Qiagen Gmbh Transfektionslösung
GB0917792D0 (en) 2009-10-12 2009-11-25 Fermentas Uab Delivery agent
US9856456B2 (en) 2009-10-12 2018-01-02 Thermo Fisher Scientific Baltics Uab Delivery agent
WO2013094748A1 (ja) 2011-12-21 2013-06-27 キリンホールディングス株式会社 細胞内に導入するための温度感受性蛍光プローブ
JP6666673B2 (ja) * 2015-09-07 2020-03-18 キリンホールディングス株式会社 細胞内送達ベヒクル
NL2026569B1 (en) 2020-09-29 2022-05-30 Crm Therapeutics B V Target mediated endocytotic drug delivery
EP4221757A1 (en) 2020-09-29 2023-08-09 CRM Therapeutics B.V. Target mediated endocytotic drug delivery

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4824850A (en) * 1982-05-18 1989-04-25 University Of Florida Brain-specific drug delivery
EP0262344B1 (de) * 1986-08-07 1996-03-27 MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG N-alkylierte quartäre stickstoffhaltige Heterozyklen, Verfahren zu deren Herstellung und deren Verwendung in Arzneimitteln
US4957785A (en) * 1988-03-25 1990-09-18 Fornadley Michael R Light transmissive stone structure and method for making same

Also Published As

Publication number Publication date
NL1000884C2 (nl) 1997-01-28
DE69602809T2 (de) 1999-12-16
US5853694A (en) 1998-12-29
DE69602809D1 (de) 1999-07-15
GR3031200T3 (en) 1999-12-31
ATE181065T1 (de) 1999-06-15
EP0755924B1 (en) 1999-06-09
JP4771564B2 (ja) 2011-09-14
EP0755924A1 (en) 1997-01-29
CA2181841C (en) 2008-01-08
DK0755924T3 (da) 1999-11-29
CA2181841A1 (en) 1997-01-26
JPH09285290A (ja) 1997-11-04

Similar Documents

Publication Publication Date Title
ES2137623T3 (es) Vehiculos de transporte para macromoleculas.
BR0212968A (pt) Composição farmacêutica, composto, e, método para tratar ou prevenir condições mediadas pelo ccr2, mcp-1 ou pela interação destes
ATE243697T1 (de) Substitutierte heterozyclische derivate als crf antagonisten
PT897904E (pt) 2-metoxibenzofenonas fungicidas
ATE219071T1 (de) Tricyclische verbindungen mit bindungsaffinität für melatoninrezeptoren, deren herstellung und verwendung
DE60042762D1 (de) Zwischenprodukte für die Herstellung von Harnstoffderivaten mit Muskarinrezeptor-antagonistischer Aktivität
BR0208126A (pt) Conjugados de ingrediente ativo de has
BR9507615A (pt) Composto e processo para produzir um composto
AU560436B2 (en) 5-substituted 1,2,4,-oxadiazole derivatives
BR0112732A (pt) Aglutinantes contendo grupos alcoxissilila e composições aglutinantes, processo para a sua preparação e seu uso
EA200200510A1 (ru) 4-карбоксиамино-2-этил-1,2,3,4-тетрагидрохинолин в кристаллической форме как ингибитор сетр
GB9916405D0 (en) Compounds for mass spectrometry
BR9909468A (pt) Composto anti-bacteriano, composição oral anti-placas, e, processo para promoção da higiene oral
BR9503536A (pt) Composto processo para sua preparação seu uso e composição farmacêutica
ATE270691T1 (de) Stabilisator zusammensetzung
BR0212353A (pt) Composto, composição farmacêutica, e, uso de um composto
BR0314312A (pt) Processo para preparar um composto, e, composto
EA200101234A1 (ru) Новые производные аминотиазола, их получение и содержащие их фармацевтические композиции
DE60139770D1 (de) Hydantoin derivate mit affinität für somatostatin rezeptoren
BR0009453A (pt) Processo para a preparação de um composto
PT98976A (pt) Processo para a preparacao de heteroarilmetilbenzenos
ATE219097T1 (de) Erythromycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE69912193D1 (de) Substituierte 2-Hydroxybenzophenone, ihre Herstellung, ihre Verwendung als fungizide und ihre fungizide Zusammensetzungen
BR9401346A (pt) Processo para a preparação de derivados de 4-amino-3-oxo-2,3,4,5-tetraidro-1,2,4-triazina e processo para a preparação de um composto
ID27440A (id) Proses untuk menyiapkan penengah-penengah

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 755924

Country of ref document: ES